ASG7_YEAST - dbPTM
ASG7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASG7_YEAST
UniProt AC P46993
Protein Name Protein ASG7
Gene Name ASG7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 209
Subcellular Localization Endomembrane system
Multi-pass membrane protein .
Protein Description Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular membranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth..
Protein Sequence MTTLASSIEHKTKHLAAPFENDENPWMKKYCCQCKSCKMSVPVQPWLPRFFVFGILCPVFWLVNLLAWWFLQYWQPHELEFHDLQEDEYPGFYEYEAITKRTVIPIKEEVLQEIRVMQNFSDSNSEEYYESKDGMPSSFLNVNTEQVEDENDTLKKYRYAFLKKVAHDVLESHDLLRKTFRDWNLRSLLGLLIDSILIIFVVLLCKKSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MTTLASSIEHKTK
--CCCHHHHHCHHHH		34.6528132839
7Phosphorylation-MTTLASSIEHKTKH
-CCCHHHHHCHHHHH		26.7928132839
107UbiquitinationKRTVIPIKEEVLQEI
CCEEEECCHHHHHHH		42.3323749301
121PhosphorylationIRVMQNFSDSNSEEY
HHHHHHCCCCCCHHH		47.9117330950
123PhosphorylationVMQNFSDSNSEEYYE
HHHHCCCCCCHHHHC		40.8517330950
125PhosphorylationQNFSDSNSEEYYESK
HHCCCCCCHHHHCCC		35.4417330950
131PhosphorylationNSEEYYESKDGMPSS
CCHHHHCCCCCCCCC		21.6717330950
138PhosphorylationSKDGMPSSFLNVNTE
CCCCCCCCCCCCCHH		28.0717330950
153PhosphorylationQVEDENDTLKKYRYA
HHCCCCHHHHHHHHH		52.6517330950
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASG7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASG7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASG7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RV161_YEASTRVS161genetic
20526336
TOR2_YEASTTOR2genetic
20526336
IMG2_YEASTIMG2genetic
27708008
CP56_YEASTDIT2genetic
27708008
PET8_YEASTPET8genetic
27708008
SAC1_YEASTSAC1genetic
29674565
PHB2_YEASTPHB2genetic
29674565
UME6_YEASTUME6genetic
29674565
UBP3_YEASTUBP3genetic
29674565
TSC3_YEASTTSC3genetic
29674565
SNF6_YEASTSNF6genetic
29674565
BRE5_YEASTBRE5genetic
29674565
POC4_YEASTPOC4genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASG7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-123; SER-125AND THR-153, AND MASS SPECTROMETRY.

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