| UniProt ID | SAC1_YEAST | |
|---|---|---|
| UniProt AC | P32368 | |
| Protein Name | Phosphoinositide phosphatase SAC1 | |
| Gene Name | SAC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 623 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein . |
|
| Protein Description | Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.. | |
| Protein Sequence | MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPLKRD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Ubiquitination | FFKLAEGKGTNDAVI EEEEECCCCCCCEEE | 54.81 | 23749301 | |
| 54 | Ubiquitination | PVQGEVVKIASLMGF CCCCEEEEHHHHHCH | 37.42 | 17644757 | |
| 99 | Ubiquitination | QHSIVSTKFNSRIDS HHHHHHCCCCCCCCH | 34.73 | 17644757 | |
| 99 | Acetylation | QHSIVSTKFNSRIDS HHHHHHCCCCCCCCH | 34.73 | 24489116 | |
| 141 | Ubiquitination | NSLQRNEKVGPAASW HHHHHCCCCCCCCCC | 56.92 | 17644757 | |
| 149 | Ubiquitination | VGPAASWKTADERFF CCCCCCCCCCCHHHH | 31.19 | 17644757 | |
| 188 | Ubiquitination | PVIYGYAKTVDAVLN HHHHCHHHHHHHHHH | 40.37 | 17644757 | |
| 223 | Acetylation | YFRRGVDKDGNVGNF HHHCCCCCCCCCCCC | 66.19 | 24489116 | |
| 246 | Ubiquitination | AENPESEKIHVFSFL ECCCCCCCEEEEEEC | 47.60 | 22106047 | |
| 270 | Ubiquitination | WAEINNLKYKPNLVL EEEECCCCCCCCEEE | 54.04 | 17644757 | |
| 271 | Phosphorylation | AEINNLKYKPNLVLG EEECCCCCCCCEEEC | 34.54 | 19823750 | |
| 272 | Ubiquitination | EINNLKYKPNLVLGE EECCCCCCCCEEECC | 26.33 | 17644757 | |
| 281 | Phosphorylation | NLVLGENSLDATKKH CEEECCCCHHHHHHH | 24.27 | 19823750 | |
| 285 | Phosphorylation | GENSLDATKKHFDQQ CCCCHHHHHHHHHHH | 40.05 | 19823750 | |
| 286 | Ubiquitination | ENSLDATKKHFDQQK CCCHHHHHHHHHHHH | 46.07 | 17644757 | |
| 287 | Ubiquitination | NSLDATKKHFDQQKE CCHHHHHHHHHHHHH | 45.19 | 17644757 | |
| 308 | Acetylation | LVNLVNQKGHELPVK HHHHHHCCCCCCCCC | 57.96 | 24489116 | |
| 308 | Ubiquitination | LVNLVNQKGHELPVK HHHHHHCCCCCCCCC | 57.96 | 17644757 | |
| 315 | Acetylation | KGHELPVKEGYESVV CCCCCCCCCCHHHHH | 43.41 | 24489116 | |
| 315 | Ubiquitination | KGHELPVKEGYESVV CCCCCCCCCCHHHHH | 43.41 | 17644757 | |
| 329 | Ubiquitination | VHALNDPKIHYVYFD HHHHHCCCEEEEEEE | 45.00 | 17644757 | |
| 350 | Acetylation | KMQWHRVKLLIDHLE HCCHHHHHHHHHHHH | 37.22 | 24489116 | |
| 358 | Ubiquitination | LLIDHLEKLGLSNED HHHHHHHHCCCCCHH | 54.97 | 22106047 | |
| 513 | Ubiquitination | RPHTASIKSPFPDRR CCCCCCCCCCCCCCC | 49.97 | 17644757 | |
| 613 | Acetylation | LKYAQSPKFSKPDPL CCCCCCCCCCCCCCC | 68.47 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SAC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SAC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SAC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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