| UniProt ID | STT4_YEAST | |
|---|---|---|
| UniProt AC | P37297 | |
| Protein Name | Phosphatidylinositol 4-kinase STT4 | |
| Gene Name | STT4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1900 | |
| Subcellular Localization | ||
| Protein Description | Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. STT4 functions in PKC1 protein kinase pathway.. | |
| Protein Sequence | MRFTRGLKASSSLRAKAIGRLTKLSTGAPNDQNSNGTTLDLITHTLPIFYSTNTSKIYTIPLTLSEWEVLTSLCVAIPTTLDLVETMLKEIIAPYFLETPRQRISDVLSSKFKLEQMRNPIELLTFQLTKFMIQACEQYPVLYENIGGIISTYFERVLKIFTIKQSGLLSLVGFINAFIQFPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSATFTNDSIVQYYDAGNELSSAYLLELISRLQVSLISHLLNTSHVGANLSEFLLNQQYQFYKFDQEVADENDDTKCIDDFFFNVRSNKQFFTDMCKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTESELFESFTNVVSESIDKFFLSDVVTPSLIKAIVASASLLNFFTEKLSLTLIRMFPLLVASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLAVSEDGSPVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLISNCVAATTTIASYYNTQSITALTISILTQKVNSMSKELDGVILNSLARLAPNTSLTEFSLLLKFFKSRTVIATKIDDSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSIIASGEVERLEHHRPQTEISRVADQIATYLEPLAALLPVPGDTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFSFLLTIAYNSPPLASEFPANNKELSLEMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRTTSSSKIMFLAAAVLLETIRCEAGDCSKTLLYFSDPSILSGSIEKCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRILLNRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTIITEKPEVAHLLLVEVCYCWMRSIDDNIGLYSRDHDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFATLVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLMSRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPEWQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQIIWNMLANCYKDDEGIQEDEIKPTLDRIRERMVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNGIPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 110 | Phosphorylation | RISDVLSSKFKLEQM HHHHHHHCCCCHHHH | 37.64 | 28889911 | |
| 459 | Phosphorylation | LAVSEDGSPVPVLRE EEECCCCCCCCEEEE | 34.74 | 28889911 | |
| 470 | Phosphorylation | VLRERQLTITSGKNI EEEEEEEEEECCCCC | 17.55 | 25752575 | |
| 472 | Phosphorylation | RERQLTITSGKNIEK EEEEEEEECCCCCCC | 26.62 | 23749301 | |
| 473 | Phosphorylation | ERQLTITSGKNIEKD EEEEEEECCCCCCCC | 43.87 | 28152593 | |
| 475 | Ubiquitination | QLTITSGKNIEKDYF EEEEECCCCCCCCCC | 55.29 | 23749301 | |
| 479 | Ubiquitination | TSGKNIEKDYFPLRN ECCCCCCCCCCCCCC | 54.66 | 23749301 | |
| 602 | Phosphorylation | IATKIDDSALLKNII EEEECCCHHHHHHHH | 19.64 | 28889911 | |
| 930 | Phosphorylation | YEFKLKHSKTTILVP EEEEECCCCEEEEEC | 30.06 | 19779198 | |
| 933 | Phosphorylation | KLKHSKTTILVPSSS EECCCCEEEEECCCC | 18.95 | 19779198 | |
| 965 | Phosphorylation | VRILLNRSNQDTKIL HHHHHCCCCCCHHHH | 37.46 | 30377154 | |
| 978 | Phosphorylation | ILLQSYISDLGEYSR HHHHHHHHHHHHHHH | 20.67 | 30377154 | |
| 1175 | Ubiquitination | MEYSPYDKAGINRDA CCCCCCCCCCCCCCC | 42.54 | 23749301 | |
| 1249 | Phosphorylation | HELLLFATLVLNASY HHHHHHHHHHHCCHH | 15.29 | 19779198 | |
| 1255 | Phosphorylation | ATLVLNASYKQGSKY HHHHHCCHHHHCCCC | 31.61 | 19779198 | |
| 1292 | Acetylation | PFGSNELKIKADLSV CCCCCCEEEEEEEHH | 35.66 | 24489116 | |
| 1533 | Phosphorylation | RIRERMVSSFSQSHR HHHHHHHHHCHHHHH | 19.14 | 27017623 | |
| 1536 | Phosphorylation | ERMVSSFSQSHRDFY HHHHHHCHHHHHHHH | 32.49 | 27017623 | |
| 1640 | Acetylation | GKNKEVEKWQAAIFK CCCHHHHHHHHHHEC | 50.19 | 24489116 | |
| 1719 | Phosphorylation | GLYEYFTSKFGNEST HHHHHHHHHCCCCCC | 18.98 | 19779198 | |
| 1725 | Phosphorylation | TSKFGNESTIEFQNA HHHCCCCCCEEEHHH | 38.39 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STT4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STT4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STT4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-459 AND SER-473, ANDMASS SPECTROMETRY. | |
