dbPTM

PFA4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PFA4_YEAST
UniProt AC	Q12006
Protein Name	Palmitoyltransferase PFA4 {ECO:0000255\|HAMAP-Rule:MF_03199, ECO:0000303\|PubMed:16751107}
Gene Name	PFA4 {ECO:0000255\|HAMAP-Rule:MF_03199, ECO:0000303\|PubMed:16751107}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	378
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. Palmitoylates several amino acid permeases. [PubMed: 16751107 Palmitoylates chitin synthase CHS3, which is required for its proper export from the ER]
Protein Sequence	MPVKLRWPWLGIAIPTFLISFIGYGAHYFILSNFLSVPKQITFEFCLSMIWLSYYLAICTNPGRPLPNYKPPPDIWRNFCKKCQSYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGFANYPHFLRFLFWIIVTTSVLFCIQAKRIYFIWQQRHLPGYFFKKSELIFLTISSPLNSFVLLTITILFLRCLFNQILNGRSQIESWDMDRLESLFNSGRLTQKLIDNTWRIYPESRSFQNKKDAEEHLTKKRPRFDELVNFPYDFDLYTNALLYLGPIHLWLWPYGVPTGDGNNFPKNGISKYEANSSLEDHILSLPWPPDGGKTNTVFNHGSSTIEMRNESGEQLIRTRLPQNGRHASREKWYNDWGESLDDFGVDVDME

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
214	Phosphorylation	RLESLFNSGRLTQKL HHHHHHHCCCHHHHH	20.25	28889911
339	Phosphorylation	TIEMRNESGEQLIRT EEEEECCCCCHHHHH	51.70	27214570

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PFA4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PFA4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PFA4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHS3_YEAST	CHS3	physical	16818716
SEC62_YEAST	SEC62	physical	18719252
PEX29_YEAST	PEX29	physical	18719252
GST1_YEAST	GTT1	physical	18719252
YGK8_YEAST	YGL108C	physical	19416974
SWC5_YEAST	SWC5	genetic	21987634
FEN2_YEAST	FEN2	genetic	21987634
THRC_YEAST	THR4	genetic	21987634
SSD1_YEAST	SSD1	genetic	21987634
SWR1_YEAST	SWR1	genetic	21987634
SWI4_YEAST	SWI4	genetic	21987634
MTO1_YEAST	MTO1	genetic	21987634
CAX4_YEAST	CAX4	genetic	21987634
MPS3_YEAST	MPS3	genetic	21987634
ILM1_YEAST	ILM1	genetic	21987634
CBT1_YEAST	CBT1	genetic	21987634
GPT2_YEAST	GPT2	genetic	21987634
CDC42_YEAST	CDC42	genetic	21987634
ERB1_YEAST	ERB1	genetic	21987634
MAS5_YEAST	YDJ1	genetic	21987634
ERG24_YEAST	ERG24	genetic	21987634
CLA4_YEAST	CLA4	genetic	21987634
PDC2_YEAST	PDC2	genetic	27708008
YP022_YEAST	YPR022C	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
ARPC5_YEAST	ARC15	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
ARPC2_YEAST	ARC35	genetic	27708008
MYO2_YEAST	MYO2	genetic	27708008
SLA1_YEAST	SLA1	genetic	27708008
ELO2_YEAST	ELO2	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
CYK3_YEAST	CYK3	genetic	27708008
PP2A1_YEAST	PPH21	genetic	27708008
MNN10_YEAST	MNN10	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
ILM1_YEAST	ILM1	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
AIM26_YEAST	AIM26	genetic	27708008
YKE44_YEAST	YKL044W	genetic	27708008
IRS4_YEAST	IRS4	genetic	27708008
YPT6_YEAST	YPT6	genetic	27708008
FKS1_YEAST	FKS1	genetic	27708008
BUL2_YEAST	BUL2	genetic	27708008
YPK2_YEAST	YPK2	genetic	27708008
DLT1_YEAST	DLT1	genetic	27708008
VTS1_YEAST	VTS1	genetic	27708008
YP066_YEAST	RGL1	genetic	27708008
AIM44_YEAST	AIM44	genetic	27708008
CR3L1_HUMAN	CREB3L1	physical	27107014
FATE1_HUMAN	FATE1	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PFA4_YEAST

Related Literatures of Post-Translational Modification