| UniProt ID | CYK3_YEAST | |
|---|---|---|
| UniProt AC | Q07533 | |
| Protein Name | Cytokinesis protein 3 | |
| Gene Name | CYK3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 885 | |
| Subcellular Localization | Cytoplasm. Bud neck. Found in association with the actin ring and the cortex at the mother-bud neck. | |
| Protein Description | Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2.. | |
| Protein Sequence | MATNLTSLKPPFKVKARYGWSGQTKGDLGFLEGDIMEVTRIAGSWFYGKLLRNKKCSGYFPHNFVILLEERLNSSTENGRQPSKIVESFEKSNKVVIPPVPSRYSDERPRPKKKLSSSMPNSPKKPVDSLTKARKAKSKEMVNEKNIYNTQSSRHHNNSAPNLPLASHSKPQVRNFEESMNNPLPPLPPLPDLDNMRKTDKRAPKKSYSANDLHMARSSREYNYYKDNQKFYDGFIPEKRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQNANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNLNLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVKGNTKPGLVDVELAELNIEYIDKMTWKRCIRDGTMTLDSWAQTTFSARYSTVLEKLRGIYIFCTEMFALTDDNGTSDFSAEPQNLEKILYRKHCTPYELTWLFKKLANSLGITCEIVIGFLKTPSAINWEFKYNHCWLRILVNKEWRFIDVILGNVTNPIHEFVNNRKIKKAENSYFLMAPLEMIYTHIPPREFEQHIVPSIDQLSALYLPLVFPSFFKNELKLYKFSTALSFLEDSEIYECSLEIPNDVEVFASVVIPTDNEEASSAYRNMELALTQIKKQKAESGRRIALIKAVLPPNVNKGSLYIHSGVRGTQTSIANIHPLSMMVPLTHKGSNMKYEFVIKIPSESIQKIELYIVEPQSRYLFVGNEYSFEVIQSPSDGIVYSSDEGPNQNRKQPMAIKSPSGRVHELVKSDPHFPYGTWKGSIKIKEPGVWSALVIADSGIGWSVFAEWLCV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Acetylation | AGSWFYGKLLRNKKC CHHHHHHHHHCCCCC | 32.73 | 24489116 | |
| 75 | Phosphorylation | LEERLNSSTENGRQP EHHHHCCCCCCCCCC | 38.37 | 23749301 | |
| 88 | Phosphorylation | QPSKIVESFEKSNKV CCHHHHHHHHHCCCE | 28.01 | 30377154 | |
| 102 | Phosphorylation | VVIPPVPSRYSDERP EECCCCCCCCCCCCC | 44.05 | 21440633 | |
| 104 | Phosphorylation | IPPVPSRYSDERPRP CCCCCCCCCCCCCCC | 25.47 | 21440633 | |
| 105 | Phosphorylation | PPVPSRYSDERPRPK CCCCCCCCCCCCCCC | 31.70 | 20377248 | |
| 116 | Phosphorylation | PRPKKKLSSSMPNSP CCCCCCCCCCCCCCC | 29.28 | 22369663 | |
| 117 | Phosphorylation | RPKKKLSSSMPNSPK CCCCCCCCCCCCCCC | 40.88 | 22369663 | |
| 118 | Phosphorylation | PKKKLSSSMPNSPKK CCCCCCCCCCCCCCC | 34.58 | 22369663 | |
| 122 | Phosphorylation | LSSSMPNSPKKPVDS CCCCCCCCCCCCHHH | 32.02 | 22369663 | |
| 129 | Phosphorylation | SPKKPVDSLTKARKA CCCCCHHHHHHHHHH | 37.87 | 28889911 | |
| 131 | Phosphorylation | KKPVDSLTKARKAKS CCCHHHHHHHHHHCC | 26.98 | 27017623 | |
| 153 | Phosphorylation | NIYNTQSSRHHNNSA HCCCCCCCCCCCCCC | 26.30 | 28889911 | |
| 159 | Phosphorylation | SSRHHNNSAPNLPLA CCCCCCCCCCCCCCC | 50.88 | 23749301 | |
| 207 | Phosphorylation | DKRAPKKSYSANDLH CCCCCCCCCCHHHHH | 30.37 | 22369663 | |
| 208 | Phosphorylation | KRAPKKSYSANDLHM CCCCCCCCCHHHHHH | 22.23 | 22369663 | |
| 209 | Phosphorylation | RAPKKSYSANDLHMA CCCCCCCCHHHHHHH | 27.90 | 22369663 | |
| 219 | Phosphorylation | DLHMARSSREYNYYK HHHHHHHHCCCCCCC | 24.47 | 21440633 | |
| 288 | Ubiquitination | AGSFARHKYAQSFSD HHHHHHHHHHHHHHH | 36.41 | 23749301 | |
| 292 | Phosphorylation | ARHKYAQSFSDSLQR HHHHHHHHHHHHHHH | 20.67 | 28889911 | |
| 313 | Phosphorylation | CSTKINDSQEFGDSN CCCCCCCCHHHCCCC | 27.41 | 22369663 | |
| 319 | Phosphorylation | DSQEFGDSNASSRNG CCHHHCCCCCCCCCC | 34.37 | 29688323 | |
| 322 | Phosphorylation | EFGDSNASSRNGKMG HHCCCCCCCCCCCHH | 33.80 | 29688323 | |
| 323 | Phosphorylation | FGDSNASSRNGKMGD HCCCCCCCCCCCHHH | 27.62 | 29688323 | |
| 342 | Phosphorylation | IIIPKRNTNIYSSSV HHCCCCCCCCCCCCC | 27.33 | 21440633 | |
| 345 | Phosphorylation | PKRNTNIYSSSVSSP CCCCCCCCCCCCCCC | 12.45 | 19823750 | |
| 346 | Phosphorylation | KRNTNIYSSSVSSPK CCCCCCCCCCCCCCC | 16.61 | 21440633 | |
| 347 | Phosphorylation | RNTNIYSSSVSSPKS CCCCCCCCCCCCCCC | 20.14 | 21440633 | |
| 348 | Phosphorylation | NTNIYSSSVSSPKSP CCCCCCCCCCCCCCC | 21.78 | 21440633 | |
| 350 | Phosphorylation | NIYSSSVSSPKSPKA CCCCCCCCCCCCCCC | 42.76 | 17330950 | |
| 351 | Phosphorylation | IYSSSVSSPKSPKAY CCCCCCCCCCCCCCC | 33.90 | 17330950 | |
| 354 | Phosphorylation | SSVSSPKSPKAYPKL CCCCCCCCCCCCCCC | 34.71 | 17330950 | |
| 370 | Phosphorylation | DIQNLNLSATPDEAR CCCCCCCCCCCHHHH | 29.08 | 24961812 | |
| 372 | Phosphorylation | QNLNLSATPDEARDW CCCCCCCCCHHHHHH | 28.09 | 24961812 | |
| 391 | Phosphorylation | CHLNRARTLTKYDKH HHHHCCCHHCCCCCC | 37.48 | 17287358 | |
| 793 | Phosphorylation | IVEPQSRYLFVGNEY EECCCCCEEEECCEE | 15.11 | 30377154 | |
| 801 | Phosphorylation | LFVGNEYSFEVIQSP EEECCEEEEEEEECC | 14.57 | 30377154 | |
| 807 | Phosphorylation | YSFEVIQSPSDGIVY EEEEEEECCCCCCEE | 18.42 | 30377154 | |
| 815 | Phosphorylation | PSDGIVYSSDEGPNQ CCCCCEECCCCCCCC | 22.03 | 30377154 | |
| 816 | Phosphorylation | SDGIVYSSDEGPNQN CCCCEECCCCCCCCC | 23.22 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CYK3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CYK3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CYK3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-209 ANDSER-313, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118 AND SER-122, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105 AND THR-391, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-354, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-122, ANDMASS SPECTROMETRY. | |
