| UniProt ID | INN1_YEAST | |
|---|---|---|
| UniProt AC | P53901 | |
| Protein Name | Ingression protein 1 | |
| Gene Name | INN1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 409 | |
| Subcellular Localization | Bud neck . Localizes at the contractile actinomyosin ring at the end of cytokinesis. Recruitment to the bud neck requires either CYK2 or CYK3. | |
| Protein Description | Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2.. | |
| Protein Sequence | MSEEVWNGNQGILSVYVSKARDLPNLNKLDKQNVMLRLRIAHMTRASNTLHRAGQNPVFHYLEKFDITPEIKPLMYVEVYCDRRKKSPLPIGRCEIDLLNAIRADPKEGYCTWYELKRSGDEFAGTIFIELTFTPKVPRLNRDDLNKEMDRLDSSMAMRPIPPLPTESEYDYVHGSTMRQITPQCVSTSHEDKDEGQPYRNGNVFSMSSKSDTAVLANSNDPIILPPTFSASMGTTSTLETNDTAISNTSNTKFHFANLRKLKEKINIFKNPDSSTNNCQNESNKVDIEALQKAIGVTSLSYDEDDDDDDENDAFYSSSHRVSHNYNQPPLPPIPTRDDMSNYSSSRNTPLVRRDRPSRLDSSSPNSHPHPSGLNSPKLPPLPTTSNSNFNSRKNSMSPTRKRPPPRLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSEEVWNGN ------CCCCCCCCC | 42.33 | 19795423 | |
| 14 | Phosphorylation | NGNQGILSVYVSKAR CCCCCEEEEEEEECC | 14.96 | 19823750 | |
| 16 | Phosphorylation | NQGILSVYVSKARDL CCCEEEEEEEECCCC | 8.81 | 19823750 | |
| 18 | Phosphorylation | GILSVYVSKARDLPN CEEEEEEEECCCCCC | 11.69 | 19823750 | |
| 182 | Phosphorylation | GSTMRQITPQCVSTS CCCCCEECCCHHCCC | 10.04 | 28889911 | |
| 187 | Phosphorylation | QITPQCVSTSHEDKD EECCCHHCCCCCCCC | 31.64 | 19779198 | |
| 189 | Phosphorylation | TPQCVSTSHEDKDEG CCCHHCCCCCCCCCC | 19.85 | 28889911 | |
| 208 | Phosphorylation | NGNVFSMSSKSDTAV CCCEEECCCCCCEEE | 33.16 | 22369663 | |
| 209 | Phosphorylation | GNVFSMSSKSDTAVL CCEEECCCCCCEEEE | 27.77 | 22369663 | |
| 244 | Phosphorylation | STLETNDTAISNTSN CEEEECCCEECCCCC | 28.14 | 21551504 | |
| 249 | Phosphorylation | NDTAISNTSNTKFHF CCCEECCCCCCEEEE | 19.30 | 21551504 | |
| 250 | Phosphorylation | DTAISNTSNTKFHFA CCEECCCCCCEEEEC | 46.91 | 21551504 | |
| 252 | Phosphorylation | AISNTSNTKFHFANL EECCCCCCEEEECCH | 34.55 | 21551504 | |
| 274 | Phosphorylation | NIFKNPDSSTNNCQN CCCCCCCCCCCCCCC | 40.08 | 28889911 | |
| 275 | Phosphorylation | IFKNPDSSTNNCQNE CCCCCCCCCCCCCCC | 42.40 | 23749301 | |
| 298 | Phosphorylation | LQKAIGVTSLSYDED HHHHHCCEEECCCCC | 20.81 | 30377154 | |
| 299 | Phosphorylation | QKAIGVTSLSYDEDD HHHHCCEEECCCCCC | 16.95 | 30377154 | |
| 301 | Phosphorylation | AIGVTSLSYDEDDDD HHCCEEECCCCCCCC | 30.24 | 30377154 | |
| 326 | Phosphorylation | SHRVSHNYNQPPLPP HCCCCCCCCCCCCCC | 15.11 | 19779198 | |
| 341 | Phosphorylation | IPTRDDMSNYSSSRN CCCCCCCCCCCCCCC | 39.34 | 28889911 | |
| 344 | Phosphorylation | RDDMSNYSSSRNTPL CCCCCCCCCCCCCCC | 26.53 | 28889911 | |
| 362 | Phosphorylation | DRPSRLDSSSPNSHP CCCCCCCCCCCCCCC | 36.99 | 25371407 | |
| 363 | Phosphorylation | RPSRLDSSSPNSHPH CCCCCCCCCCCCCCC | 49.86 | 28889911 | |
| 364 | Phosphorylation | PSRLDSSSPNSHPHP CCCCCCCCCCCCCCC | 31.86 | 21082442 | |
| 367 | Phosphorylation | LDSSSPNSHPHPSGL CCCCCCCCCCCCCCC | 41.60 | 28889911 | |
| 372 | Phosphorylation | PNSHPHPSGLNSPKL CCCCCCCCCCCCCCC | 53.53 | 23749301 | |
| 376 | Phosphorylation | PHPSGLNSPKLPPLP CCCCCCCCCCCCCCC | 28.58 | 24930733 | |
| 384 | Phosphorylation | PKLPPLPTTSNSNFN CCCCCCCCCCCCCCC | 51.01 | 28132839 | |
| 385 | Phosphorylation | KLPPLPTTSNSNFNS CCCCCCCCCCCCCCC | 24.79 | 30377154 | |
| 386 | Phosphorylation | LPPLPTTSNSNFNSR CCCCCCCCCCCCCCC | 40.51 | 28889911 | |
| 388 | Phosphorylation | PLPTTSNSNFNSRKN CCCCCCCCCCCCCCC | 42.43 | 25704821 | |
| 392 | Phosphorylation | TSNSNFNSRKNSMSP CCCCCCCCCCCCCCC | 40.26 | 21551504 | |
| 396 | Phosphorylation | NFNSRKNSMSPTRKR CCCCCCCCCCCCCCC | 24.54 | 23749301 | |
| 398 | Phosphorylation | NSRKNSMSPTRKRPP CCCCCCCCCCCCCCC | 23.96 | 23749301 | |
| 400 | Phosphorylation | RKNSMSPTRKRPPPR CCCCCCCCCCCCCCC | 41.33 | 27717283 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of INN1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of INN1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of INN1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386, AND MASSSPECTROMETRY. | |
