| UniProt ID | MYO1_YEAST | |
|---|---|---|
| UniProt AC | P08964 | |
| Protein Name | Myosin-1 | |
| Gene Name | MYO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1928 | |
| Subcellular Localization | ||
| Protein Description | Required for cell division.. | |
| Protein Sequence | MTGGQSCSSNMIVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQASFKNDVSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKEDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKIKELEARLSQEISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQTLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKIHELENMVSLETDLKYEEMKKNKSLERAVEELQTKNSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQELEMKKSIRDNSSYRDKVQEMAQEIEFWKSRYESTMIGSKNIDSNNAQSKIFS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 175 | Phosphorylation | LSEGKDQSILVTGES HHCCCCCEEEEECCC | 28.20 | 21551504 | |
| 179 | Phosphorylation | KDQSILVTGESGAGK CCCEEEEECCCCCCC | 31.61 | 26447709 | |
| 182 | Phosphorylation | SILVTGESGAGKTEN EEEEECCCCCCCCCC | 34.98 | 26447709 | |
| 187 | Phosphorylation | GESGAGKTENTKKIL CCCCCCCCCCHHHHH | 33.28 | 26447709 | |
| 190 | Phosphorylation | GAGKTENTKKILQYL CCCCCCCHHHHHHHH | 27.73 | 26447709 | |
| 245 | Phosphorylation | QTVRNNNSSRFGKFI HHHCCCCCCCCEEEE | 25.64 | 30377154 | |
| 746 | Acetylation | TTTTFSSKLKASTKQ CCCCCHHHHCCCCCC | 53.46 | 24489116 | |
| 917 | Phosphorylation | ENLRKNESLLNRVKT HHHHHCHHHHHHHHC | 47.77 | 23749301 | |
| 924 | Phosphorylation | SLLNRVKTSSETLQK HHHHHHHCCHHHHHH | 34.33 | 23749301 | |
| 925 | Phosphorylation | LLNRVKTSSETLQKQ HHHHHHCCHHHHHHH | 22.06 | 23749301 | |
| 990 | Phosphorylation | NELIKQISDLNCDIS HHHHHHHHHCCCCCC | 33.29 | 30377154 | |
| 1068 | Phosphorylation | SRLQSLVTENSDLRS HHHHHHHHCCHHHHH | 34.44 | 30377154 | |
| 1071 | Phosphorylation | QSLVTENSDLRSKNE HHHHHCCHHHHHCCH | 31.61 | 30377154 | |
| 1171 | Phosphorylation | QEQKKRNSLVESLND HHHHHHHHHHHHHCH | 37.51 | 19823750 | |
| 1175 | Phosphorylation | KRNSLVESLNDSKIK HHHHHHHHHCHHHHH | 25.62 | 21440633 | |
| 1203 | Phosphorylation | QYLNKRISGNSVETN HHHHHCCCCCCEEEC | 35.63 | 23749301 | |
| 1206 | Phosphorylation | NKRISGNSVETNISS HHCCCCCCEEECCCC | 25.51 | 25752575 | |
| 1217 | Phosphorylation | NISSTRRSTSYSDDP CCCCCCCCCCCCCCC | 20.58 | 28889911 | |
| 1218 | Phosphorylation | ISSTRRSTSYSDDPL CCCCCCCCCCCCCCC | 29.85 | 17330950 | |
| 1219 | Phosphorylation | SSTRRSTSYSDDPLD CCCCCCCCCCCCCCC | 24.72 | 28152593 | |
| 1221 | Phosphorylation | TRRSTSYSDDPLDKE CCCCCCCCCCCCCHH | 34.99 | 19779198 | |
| 1351 | Acetylation | AISALHSKFRKIQGE HHHHHHHHHHHHCCC | 38.14 | 24489116 | |
| 1359 | Phosphorylation | FRKIQGESSLSSSDI HHHHCCCCCCCHHHH | 43.32 | 24961812 | |
| 1360 | Phosphorylation | RKIQGESSLSSSDIY HHHCCCCCCCHHHHH | 28.15 | 24961812 | |
| 1362 | Phosphorylation | IQGESSLSSSDIYKL HCCCCCCCHHHHHHH | 29.73 | 23749301 | |
| 1363 | Phosphorylation | QGESSLSSSDIYKLK CCCCCCCHHHHHHHE | 37.01 | 24961812 | |
| 1364 | Phosphorylation | GESSLSSSDIYKLKF CCCCCCHHHHHHHEE | 25.34 | 24961812 | |
| 1403 | Ubiquitination | LPVGDIIKNRDSISK CCHHHHHCCCCHHHH | 46.38 | 23749301 | |
| 1475 | Phosphorylation | ERQKELLSSTIKQQK HHHHHHHHHHHHHHH | 37.75 | 21126336 | |
| 1476 | Phosphorylation | RQKELLSSTIKQQKQ HHHHHHHHHHHHHHH | 33.84 | 17287358 | |
| 1477 | Phosphorylation | QKELLSSTIKQQKQQ HHHHHHHHHHHHHHH | 28.90 | 17287358 | |
| 1573 | Acetylation | SDDLAHLKERLSAVE HHHHHHHHHHHHHHC | 30.81 | 24489116 | |
| 1615 | Phosphorylation | KEFATLKYKLETSTN HHHHEEEEEEECCCC | 24.74 | 19823750 | |
| 1619 | Phosphorylation | TLKYKLETSTNDSEA EEEEEEECCCCCCHH | 51.81 | 19823750 | |
| 1620 | Phosphorylation | LKYKLETSTNDSEAK EEEEEECCCCCCHHH | 18.81 | 19823750 | |
| 1621 | Phosphorylation | KYKLETSTNDSEAKI EEEEECCCCCCHHHH | 50.92 | 19823750 | |
| 1624 | Phosphorylation | LETSTNDSEAKISDL EECCCCCCHHHHHHH | 41.33 | 19823750 | |
| 1684 | Ubiquitination | IVSLTKIKQELESDL HEHHHHHHHHHHHHH | 39.00 | 23749301 | |
| 1701 | Phosphorylation | KTDALQISNAALSSS HCCHHHHHHHHHCCC | 13.88 | 25521595 | |
| 1866 | Phosphorylation | LKYEAQISDLEKYIS HHHHHHHHHHHHHHC | 24.86 | 21551504 | |
| 1924 | Phosphorylation | IDSNNAQSKIFS--- CCCCCCCCCCCC--- | 25.88 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MYO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1171 AND SER-1206, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1171, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1476 AND THR-1477, ANDMASS SPECTROMETRY. | |
