FUR4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUR4_YEAST
• UniProt AC: P05316
• Protein Name: Uracil permease
• Gene Name: FUR4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 633
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Transport of uracil..
• Protein Sequence: MPDNLSLHLSGSSKRLNSRQLMESSNETFAPNNVDLEKEYKSSQSNITTEVYEASSFEEKVSSEKPQYSSFWKKIYYEYVVVDKSILGVSILDSFMYNQDLKPVEKERRVWSWYNYCYFWLAECFNINTWQIAATGLQLGLNWWQCWITIWIGYGFVGAFVVLASRVGSAYHLSFPISSRASFGIFFSLWPVINRVVMAIVWYSVQAYIAATPVSLMLKSIFGKDLQDKIPDHFGSPNATTYEFMCFFIFWAASLPFLLVPPHKIRHLFTVKAVLVPFASFGFLIWAIRRAHGRIALGSLTDVQPHGSAFSWAFLRSLMGCMANFSTMVINAPDFSRFSKNPNSALWSQLVCIPFLFSITCLIGILVTAAGYEIYGINYWSPLDVLEKFLQTTYNKGTRAGVFLISFVFAVAQLGTNISANSLSCGTDMSAIFPKFINIKRGSLFCAAMALCICPWNLMATSSKFTMALSAYAIFLSSIAGVVCSDYFVVRRGYIKLTHIYSHQKGSFYMYGNRFGINWRALAAYLCGVAPCLPGFIAEVGAPAIKVSDGAMKLYYLSYWVGYGLSFSSYTALCYFFPVPGCPVNNIIKDKGWFQRWANVDDFEEEWKDTIERDDLVDDNISVYEHEHEKTFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPDNLSLHLSGSS --CCCCCEEECCCCC	21.72	28152593
10	Phosphorylation	DNLSLHLSGSSKRLN CCCEEECCCCCCCCC	26.36	19823750
12	Phosphorylation	LSLHLSGSSKRLNSR CEEECCCCCCCCCHH	29.34	19823750
13	Phosphorylation	SLHLSGSSKRLNSRQ EEECCCCCCCCCHHH	25.89	19823750
38	Ubiquitination	PNNVDLEKEYKSSQS CCCCCHHHHHHHCCC	73.89	23749301
41	Ubiquitination	VDLEKEYKSSQSNIT CCHHHHHHHCCCCCE	44.73	22817900
43	Phosphorylation	LEKEYKSSQSNITTE HHHHHHHCCCCCEEE	33.21	10811641
45	Phosphorylation	KEYKSSQSNITTEVY HHHHHCCCCCEEEEE	31.95	10811641
55	Phosphorylation	TTEVYEASSFEEKVS EEEEEHHHCHHHHHC	24.50	10811641
56	Phosphorylation	TEVYEASSFEEKVSS EEEEHHHCHHHHHCC	43.66	10811641
62	Phosphorylation	SSFEEKVSSEKPQYS HCHHHHHCCCCCCCH	43.79	28889911
65	Ubiquitination	EEKVSSEKPQYSSFW HHHHCCCCCCCHHHH	39.09	23749301
501	Phosphorylation	YIKLTHIYSHQKGSF EEEEEEEEEECCCEE	7.78	27017623
507	Phosphorylation	IYSHQKGSFYMYGNR EEEECCCEEEEECCC	21.90	27017623
509	Phosphorylation	SHQKGSFYMYGNRFG EECCCEEEEECCCCC	7.36	27017623
511	Phosphorylation	QKGSFYMYGNRFGIN CCCEEEEECCCCCCC	10.40	27017623
622	Phosphorylation	DLVDDNISVYEHEHE HCCCCCCEEEEECCH	25.54	25521595
624	Phosphorylation	VDDNISVYEHEHEKT CCCCCEEEEECCHHC	12.55	29688323

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUR4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUR4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAN1_YEAST	CAN1	physical	15536122
SUR7_YEAST	SUR7	physical	15536122
FUI1_YEAST	FUI1	genetic	9485596

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-622, AND MASSSPECTROMETRY.
PubMed: 18407956