SUR7_YEAST - dbPTM
SUR7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SUR7_YEAST
UniProt AC P54003
Protein Name Protein SUR7
Gene Name SUR7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 302
Subcellular Localization Cell membrane
Multi-pass membrane protein . Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Protein Description Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis..
Protein Sequence MVKVWNIVLRLVVLLFLAGNTLLLILMIISGATDHYPVNRFYWVQGNTTGIPNAGDETRWTFWGACLQDKDGSDTCTSNLAPAYPISPVDNFNTHINVPHQFISKRDAFYYLTRFSFCFFWIALAFVGVSFILYVLTWCSKMLSEMVLILMSFGFVFNTAAVVLQTAASAMAKNAFHDDHRSAQLGASMMGMAWASVFLCIVEFILLVFWSVRARLASTYSIDNSRYRTSSRWNPFHREKEQATDPILTATGPEDMQQSASIVGPSSNANPVTATAATENQPKGINFFTIRKSHERPDDVSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
47N-linked_GlycosylationRFYWVQGNTTGIPNA
CEEEEECCCCCCCCC		19.85-
152PhosphorylationEMVLILMSFGFVFNT
HHHHHHHHCCHHHHH		20.8327017623
218PhosphorylationSVRARLASTYSIDNS
HHHHHHHHCEECCCC		32.2521126336
219PhosphorylationVRARLASTYSIDNSR
HHHHHHHCEECCCCC		18.7128889911
220PhosphorylationRARLASTYSIDNSRY
HHHHHHCEECCCCCC		10.9230377154
221PhosphorylationARLASTYSIDNSRYR
HHHHHCEECCCCCCC		24.4524909858
225PhosphorylationSTYSIDNSRYRTSSR
HCEECCCCCCCCCCC		27.2627017623
240UbiquitinationWNPFHREKEQATDPI
CCCCCCCHHHCCCCC		55.9023749301
244PhosphorylationHREKEQATDPILTAT
CCCHHHCCCCCCCCC		41.8430377154
249PhosphorylationQATDPILTATGPEDM
HCCCCCCCCCCHHHH		23.9323749301
251PhosphorylationTDPILTATGPEDMQQ
CCCCCCCCCHHHHHH		48.2923749301
259PhosphorylationGPEDMQQSASIVGPS
CHHHHHHHHHEECCC		13.6925521595
261PhosphorylationEDMQQSASIVGPSSN
HHHHHHHHEECCCCC		24.0520377248
266PhosphorylationSASIVGPSSNANPVT
HHHEECCCCCCCCCC		30.2328889911
267PhosphorylationASIVGPSSNANPVTA
HHEECCCCCCCCCCC		42.9921440633
273PhosphorylationSSNANPVTATAATEN
CCCCCCCCCEEECCC		21.3928889911
275PhosphorylationNANPVTATAATENQP
CCCCCCCEEECCCCC		13.8829688323
278PhosphorylationPVTATAATENQPKGI
CCCCEEECCCCCCCE		32.7629688323
289PhosphorylationPKGINFFTIRKSHER
CCCEEEEEEECCCCC		18.7428889911
292UbiquitinationINFFTIRKSHERPDD
EEEEEEECCCCCCCC		52.9223749301
293PhosphorylationNFFTIRKSHERPDDV
EEEEEECCCCCCCCC		22.2622369663
301PhosphorylationHERPDDVSV------
CCCCCCCCC------		29.1522369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SUR7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SUR7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SUR7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOR2_YEASTTOR2genetic
20526336
PSD1_YEASTPSD1genetic
23891562
NHX1_YEASTNHX1genetic
23891562
GET2_YEASTGET2genetic
23891562
TLG2_YEASTTLG2genetic
23891562
RGP1_YEASTRGP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
VPS1_YEASTVPS1genetic
23891562
MSMO_YEASTERG25genetic
23891562
ERG3_YEASTERG3genetic
23891562
PACC_YEASTRIM101genetic
23891562
FUB1_YEASTFUB1genetic
27708008
KEX1_YEASTKEX1genetic
27708008
SHU1_YEASTSHU1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
NUR1_YEASTNUR1genetic
27708008
ATG20_YEASTATG20genetic
27708008
TRS85_YEASTTRS85genetic
27708008
SAC3_YEASTSAC3genetic
27708008
H2A1_YEASTHTA1genetic
27708008
RV167_YEASTRVS167genetic
27708008
SNF1_YEASTSNF1genetic
27708008
FLO8_YEASTFLO8genetic
27708008
MAD1_YEASTMAD1genetic
27708008
YIP5_YEASTYIP5genetic
27708008
FZF1_YEASTFZF1genetic
27708008
6PGD2_YEASTGND2genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
YI014_YEASTYIL014C-Agenetic
27708008
YJQ3_YEASTYJL163Cgenetic
27708008
RCY1_YEASTRCY1genetic
27708008
CYP7_YEASTCPR7genetic
27708008
MNS1_YEASTMNS1genetic
27708008
ERG3_YEASTERG3genetic
27708008
MID2_YEASTMID2genetic
27708008
TPM1_YEASTTPM1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
ATP23_YEASTATP23genetic
27708008
PP2A4_YEASTPPG1genetic
27708008
TLG2_YEASTTLG2genetic
27708008
PDR5_YEASTPDR5genetic
27708008
FYV12_YEASTFYV12genetic
27708008
PALA_YEASTRIM20genetic
27708008
ISW2_YEASTISW2genetic
27708008
VTS1_YEASTVTS1genetic
27708008
RMI1_YEASTRMI1genetic
27708008
OAZ_YEASTOAZ1genetic
27708008
YP066_YEASTRGL1genetic
27708008
PRPD_YEASTPDH1genetic
27708008
SULX_YEASTYPR003Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SUR7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-301, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-301, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-301, ANDMASS SPECTROMETRY.

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