MNS1_YEAST - dbPTM
MNS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MNS1_YEAST
UniProt AC P32906
Protein Name Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Gene Name MNS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 549
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type II membrane protein.
Protein Description Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2)..
Protein Sequence MKNSVGISIATIVAIIAAIYYVPWYEHFERKSPGAGEMRDRIESMFLESWRDYSKHGWGYDVYGPIEHTSHNMPRGNQPLGWIIVDSVDTLMLMYNSSTLYKSEFEAEIQRSEHWINDVLDFDIDAEVNVFETTIRMLGGLLSAYHLSDVLEVGNKTVYLNKAIDLGDRLALAFLSTQTGIPYSSINLHSGQAVKNHADGGASSTAEFTTLQMEFKYLAYLTGNRTYWELVERVYEPLYKNNDLLNTYDGLVPIYTFPDTGKFGASTIRFGSRGDSFYEYLLKQYLLTHETLYYDLYRKSMEGMKKHLLAQSKPSSLWYIGEREQGLHGQLSPKMDHLVCFMGGLLASGSTEGLSIHEARRRPFFSLSLERKSDWDLAKGITDTCYQMYKQSSSGLAPEIVVFNDGNIKQDGWWRSSVGDFFVKPLDRHNLQRPETVESIMFMYHLSHDHKYREWGAEIATSFFENTCVDCNDPKLRRFTSLSDCITLPTKKSNNMESFWLAETLKYLYILFLDEFDLTKVVFNTEAHPFPVLDEEILKSQSLTTGWSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
96N-linked_GlycosylationDTLMLMYNSSTLYKS
CHHHHHHCCCCCCHH		18.60-
155N-linked_GlycosylationSDVLEVGNKTVYLNK
HHHHHCCCEEEECCE		41.84-
224N-linked_GlycosylationYLAYLTGNRTYWELV
HHHHHHCCCHHHHHH		28.08-
417PhosphorylationQDGWWRSSVGDFFVK
CCCEEHHHHHCEEEC		22.8829734811
424AcetylationSVGDFFVKPLDRHNL
HHHCEEECCCCCCCC		34.4024489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MNS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MNS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MNS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EMC2_YEASTEMC2genetic
16269340
TSC3_YEASTTSC3genetic
16269340
KEX2_YEASTKEX2genetic
16269340
BFR1_YEASTBFR1genetic
16269340
COPE_YEASTSEC28genetic
16269340
CSK2B_YEASTCKB1genetic
14764870
PLMT_YEASTOPI3genetic
19325107
GET2_YEASTGET2genetic
19325107
CSG2_YEASTCSG2genetic
23891562
SEC22_YEASTSEC22genetic
27708008
MVD1_YEASTMVD1genetic
27708008
CH10_YEASTHSP10genetic
27708008
PP2C4_YEASTPTC4genetic
27708008
IMG2_YEASTIMG2genetic
27708008
ATU2_YEASTCCC2genetic
27708008
VAM7_YEASTVAM7genetic
27708008
FHN1_YEASTFHN1genetic
27708008
TOM7_YEASTTOM7genetic
27708008
KCC2_YEASTCMK2genetic
27708008
HAP5_YEASTHAP5genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
CALM_YEASTCMD1genetic
27708008
SLI15_YEASTSLI15genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP11_YEASTPRP11genetic
27708008
FAL1_YEASTFAL1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
ACT_YEASTACT1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
DBF2_YEASTDBF2genetic
27708008
NEP1_YEASTEMG1genetic
27708008
CDC3_YEASTCDC3genetic
27708008
AFG2_YEASTAFG2genetic
27708008
SEC65_YEASTSEC65genetic
27708008
ERO1_YEASTERO1genetic
27708008
DPOA_YEASTPOL1genetic
27708008
EIF3B_YEASTPRT1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
NPL4_YEASTNPL4genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
NGR1_YEASTNGR1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RGD1_YEASTRGD1genetic
27708008
STE50_YEASTSTE50genetic
27708008
ADP1_YEASTADP1genetic
27708008
DPO4_YEASTPOL4genetic
27708008
PMP1_YEASTPMP1genetic
27708008
RIM1_YEASTRIM1genetic
27708008
GIS1_YEASTGIS1genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
ADH4_YEASTADH4genetic
27708008
TNA1_YEASTTNA1genetic
27708008
KC11_YEASTYCK1genetic
27708008
ATG32_YEASTATG32genetic
27708008
IZH3_YEASTIZH3genetic
27708008
OSW2_YEASTOSW2genetic
27708008
COA4_YEASTCOA4genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
EFM7_YEASTNNT1genetic
27708008
CDC73_YEASTCDC73genetic
27708008
ICY1_YEASTICY1genetic
27708008
GFD1_YEASTGFD1genetic
27708008
COX7_YEASTCOX7genetic
27708008
SCS7_YEASTSCS7genetic
27708008
SWS2_YEASTSWS2genetic
27708008
OCA1_YEASTOCA1genetic
27708008
DCAM_YEASTSPE2genetic
27708008
PUR6_YEASTADE2genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
BEM3_YEASTBEM3genetic
27708008
COX10_YEASTCOX10genetic
27708008
KEL3_YEASTKEL3genetic
27708008
HDA3_YEASTHDA3genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MNS1_YEAST

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Related Literatures of Post-Translational Modification

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