PUR6_YEAST - dbPTM
PUR6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUR6_YEAST
UniProt AC P21264
Protein Name Phosphoribosylaminoimidazole carboxylase
Gene Name ADE2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 571
Subcellular Localization
Protein Description
Protein Sequence MDSRTVGILGGGQLGRMIVEAANRLNIKTVILDAENSPAKQISNSNDHVNGSFSNPLDIEKLAEKCDVLTIEIEHVDVPTLKNLQVKHPKLKIYPSPETIRLIQDKYIQKEHLIKNGIAVTQSVPVEQASETSLLNVGRDLGFPFVLKSRTLAYDGRGNFVVKNKEMIPEALEVLKDRPLYAEKWAPFTKELAVMIVRSVNGLVFSYPIVETIHKDNICDLCYAPARVPDSVQLKAKLLAENAIKSFPGCGIFGVEMFYLETGELLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNFTSFSTITTNAIMLNVLGDKHTKDKELETCERALATPGSSVYLYGKESRPNRKVGHINIIASSMAECEQRLNYITGRTDIPIKISVAQKLDLEAMVKPLVGIIMGSDSDLPVMSAACAVLKDFGVPFEVTIVSAHRTPHRMSAYAISASKRGIKTIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSCLDGVDSLHSIVQMPRGVPVATVAINNSTNAALLAVRLLGAYDSSYTTKMEQFLLKQEEEVLVKAQKLETVGYEAYLENK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationANRLNIKTVILDAEN
HHHCCCEEEEEECCC		14.6919823750
37PhosphorylationVILDAENSPAKQISN
EEEECCCCCCHHCCC		20.1022369663
61AcetylationSNPLDIEKLAEKCDV
CCCCCHHHHHHHCCE		54.0224489116
176AcetylationPEALEVLKDRPLYAE
HHHHHHHHCCCCCHH		57.7924489116
2352-HydroxyisobutyrylationVPDSVQLKAKLLAEN
CCCHHHHHHHHHHHH		26.78-
351AcetylationSSVYLYGKESRPNRK
CEEEEECCCCCCCCC		38.6724489116
489UbiquitinationPVIGVPVKGSCLDGV
CEECCCCCCCCCCCH		38.7522817900
558AcetylationEVLVKAQKLETVGYE
HHHHHHHHCCCCCCH		53.8224489116
564PhosphorylationQKLETVGYEAYLENK
HHCCCCCCHHHHCCC		7.9527017623
567PhosphorylationETVGYEAYLENK---
CCCCCHHHHCCC---		11.5627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUR6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUR6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUR6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PUR6_YEASTADE2physical
10688190
RAD18_YEASTRAD18physical
10688190
SED4_YEASTSED4physical
10688190
DCP1_YEASTDCP1genetic
16630557
PUR1_YEASTADE4genetic
9589850
PUR3_YEASTADE8genetic
9589850
PUR4_YEASTADE6genetic
9589850
PUR2_YEASTADE5,7genetic
9589850
HPRT_YEASTHPT1genetic
18245832
SSB2_YEASTSSB2physical
18762987
ZUO1_YEASTZUO1genetic
18762987
SSZ1_YEASTSSZ1genetic
18762987
SSB2_YEASTSSB2genetic
18762987
SSB1_YEASTSSB1genetic
18762987
HPRT_YEASTHPT1genetic
21623372
FCY2_YEASTFCY2genetic
21623372
MTU1_YEASTSLM3genetic
27708008
HPRT_YEASTHPT1genetic
27708008
AP2_YEASTCAD1genetic
27708008
FCY2_YEASTFCY2genetic
27708008
PTK2_YEASTPTK2genetic
27708008
IXR1_YEASTIXR1genetic
27708008
BAS1_YEASTBAS1genetic
27708008
MGR3_YEASTMGR3genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUR6_YEAST

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Related Literatures of Post-Translational Modification

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