dbPTM

PUR1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUR1_YEAST
UniProt AC	P04046
Protein Name	Amidophosphoribosyltransferase
Gene Name	ADE4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	510
Subcellular Localization
Protein Description
Protein Sequence	MCGILGIVLANQTTPVAPELCDGCIFLQHRGQDAAGIATCGSRGRIYQCKGNGMARDVFTQQRVSGLAGSMGIAHLRYPTAGSSANSEAQPFYVNSPYGINLAHNGNLVNTASLKRYMDEDVHRHINTDSDSELLLNIFAAELEKHNKYRVNNEDVFHALEGVYRLCRGGYACVGLLAGFALFGFRDPNGIRPLLFGERENPDGTKDYMLASESVVFKAHNFTKYRDLKPGEAVIIPKNCSKGEPEFKQVVPINSYRPDLFEYVYFARPDSVLDGISVYHTRLAMGSKLAENILKQLKPEDIDVVIPVPDTARTCALECANVLGKPYREGFVKNRYVGRTFIMPNQRERVSSVRRKLNPMESEFKGKKVLIVDDSIVRGTTSKEIVNMAKESGATKVYFASAAPAIRYNHIYGIDLTDTKNLIAYNRTDEEVAEVIGCERVIYQSLEDLIDCCKTDKITKFEDGVFTGNYVTGVEDGYIQELEEKRESIANNSSDMKAEVDIGLYNCADY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Ubiquitination	RGRIYQCKGNGMARD CCCEEEECCCCCCCC	39.63	23749301
145	Acetylation	IFAAELEKHNKYRVN HHHHHHHHCCCCCCC	66.17	24489116
288	Ubiquitination	TRLAMGSKLAENILK HHHHHCHHHHHHHHH	46.09	23749301
420	Acetylation	GIDLTDTKNLIAYNR CEECCCCCCEEECCC	53.20	24489116
445	Phosphorylation	CERVIYQSLEDLIDC CCHHHHHCHHHHHHH	19.43	27017623
488	Phosphorylation	ELEEKRESIANNSSD HHHHHHHHHHHCCHH	30.91	22369663
493	Phosphorylation	RESIANNSSDMKAEV HHHHHHCCHHHHEEE	27.76	28889911
494	Phosphorylation	ESIANNSSDMKAEVD HHHHHCCHHHHEEEE	43.79	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUR1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUR1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUR1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CYS3_YEAST	CYS3	physical	11805826
RNA1_YEAST	RNA1	physical	11805826
ADE_YEAST	AAH1	genetic	3072477
HPRT_YEAST	HPT1	genetic	18245832
PUR1_YEAST	ADE4	physical	18467557
PUR1_YEAST	ADE4	physical	18719252
FCY2_YEAST	FCY2	genetic	21623372
HPRT_YEAST	HPT1	genetic	21623372
CSG2_YEAST	CSG2	genetic	21623372
DCAM_YEAST	SPE2	genetic	21623372
GGPPS_YEAST	BTS1	genetic	21623372
MAL31_YEAST	MAL31	genetic	21623372
CYS3_YEAST	CYS3	genetic	21623372
KCS1_YEAST	KCS1	genetic	21623372
PUR1_YEAST	ADE4	physical	22615397
MCES_YEAST	ABD1	genetic	27708008
CDC10_YEAST	CDC10	genetic	27708008
ARP2_YEAST	ARP2	genetic	27708008
SEC7_YEAST	SEC7	genetic	27708008
COPD_YEAST	RET2	genetic	27708008
PSF2_YEAST	PSF2	genetic	27708008
RPN7_YEAST	RPN7	genetic	27708008
UBR2_YEAST	UBR2	genetic	27708008
TFC3_YEAST	TFC3	genetic	27708008
TAF5_YEAST	TAF5	genetic	27708008
DPOD_YEAST	POL3	genetic	27708008
RRP1_YEAST	RRP1	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
POB3_YEAST	POB3	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
PROF_YEAST	PFY1	genetic	27708008
CLP1_YEAST	CLP1	genetic	27708008
ASA1_YEAST	ASA1	genetic	27708008
ELO2_YEAST	ELO2	genetic	27708008
SWF1_YEAST	SWF1	genetic	27708008
HPRT_YEAST	HPT1	genetic	27708008
FCY2_YEAST	FCY2	genetic	27708008
MNS1_YEAST	MNS1	genetic	27708008
RL8B_YEAST	RPL8B	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
YNL5_YEAST	YNL115C	genetic	27708008
YO223_YEAST	DSC3	genetic	27708008
WDR6_YEAST	RTT10	genetic	27708008
UBC9_HUMAN	UBE2I	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUR1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, AND MASSSPECTROMETRY.	18407956 [Abstract]