TFC3_YEAST - dbPTM
TFC3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TFC3_YEAST
UniProt AC P34111
Protein Name Transcription factor tau 138 kDa subunit
Gene Name TFC3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1160
Subcellular Localization Nucleus. Mitochondrion.
Protein Description TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding..
Protein Sequence MVLTIYPDELVQIVSDKIASNKGKITLNQLWDISGKYFDLSDKKVKQFVLSCVILKKDIEVYCDGAITTKNVTDIIGDANHSYSVGITEDSLWTLLTGYTKKESTIGNSAFELLLEVAKSGEKGINTMDLAQVTGQDPRSVTGRIKKINHLLTSSQLIYKGHVVKQLKLKKFSHDGVDSNPYINIRDHLATIVEVVKRSKNGIRQIIDLKRELKFDKEKRLSKAFIAAIAWLDEKEYLKKVLVVSPKNPAIKIRCVKYVKDIPDSKGSPSFEYDSNSADEDSVSDSKAAFEDEDLVEGLDNFNATDLLQNQGLVMEEKEDAVKNEVLLNRFYPLQNQTYDIADKSGLKGISTMDVVNRITGKEFQRAFTKSSEYYLESVDKQKENTGGYRLFRIYDFEGKKKFFRLFTAQNFQKLTNAEDEISVPKGFDELGKSRTDLKTLNEDNFVALNNTVRFTTDSDGQDIFFWHGELKIPPNSKKTPNKNKRKRQVKNSTNASVAGNISNPKRIKLEQHVSTAQEPKSAEDSPSSNGGTVVKGKVVNFGGFSARSLRSLQRQRAILKVMNTIGGVAYLREQFYESVSKYMGSTTTLDKKTVRGDVDLMVESEKLGARTEPVSGRKIIFLPTVGEDAIQRYILKEKDSKKATFTDVIHDTEIYFFDQTEKNRFHRGKKSVERIRKFQNRQKNAKIKASDDAISKKSTSVNVSDGKIKRRDKKVSAGRTTVVVENTKEDKTVYHAGTKDGVQALIRAVVVTKSIKNEIMWDKITKLFPNNSLDNLKKKWTARRVRMGHSGWRAYVDKWKKMLVLAIKSEKISLRDVEELDLIKLLDIWTSFDEKEIKRPLFLYKNYEENRKKFTLVRDDTLTHSGNDLAMSSMIQREISSLKKTYTRKISASTKDLSKSQSDDYIRTVIRSILIESPSTTRNEIEALKNVGNESIDNVIMDMAKEKQIYLHGSKLECTDTLPDILENRGNYKDFGVAFQYRCKVNELLEAGNAIVINQEPSDISSWVLIDLISGELLNMDVIPMVRNVRPLTYTSRRFEIRTLTPPLIIYANSQTKLNTARKSAVKVPLGKPFSRLWVNGSGSIRPNIWKQVVTMVVNEIIFHPGITLSRLQSRCREVLSLHEISEICKWLLERQVLITTDFDGYWVNHNWYSIYEST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationSGKYFDLSDKKVKQF
CCCEECCCCHHHHHH		49.5928889911
147UbiquitinationSVTGRIKKINHLLTS
HHHHHHHHHHHHHCC		46.5017644757
160UbiquitinationTSSQLIYKGHVVKQL
CCCHHEECCCHHEEE		35.2317644757
223UbiquitinationDKEKRLSKAFIAAIA
CHHHHHHHHHHHHHH		52.4817644757
235UbiquitinationAIAWLDEKEYLKKVL
HHHHHCCHHHHHHEE		51.8617644757
239UbiquitinationLDEKEYLKKVLVVSP
HCCHHHHHHEEEECC		39.6817644757
240UbiquitinationDEKEYLKKVLVVSPK
CCHHHHHHEEEECCC		37.9017644757
275PhosphorylationSPSFEYDSNSADEDS
CCCCCCCCCCCCCCC		31.6127214570
277PhosphorylationSFEYDSNSADEDSVS
CCCCCCCCCCCCCCC		40.8420377248
282PhosphorylationSNSADEDSVSDSKAA
CCCCCCCCCCCHHHH		22.8220377248
284PhosphorylationSADEDSVSDSKAAFE
CCCCCCCCCHHHHHC		39.8721440633
286PhosphorylationDEDSVSDSKAAFEDE
CCCCCCCHHHHHCCH		19.3820377248
371PhosphorylationFQRAFTKSSEYYLES
HHHHHHHCCCHHHHH		25.9127017623
372PhosphorylationQRAFTKSSEYYLESV
HHHHHHCCCHHHHHH		31.0427017623
434PhosphorylationGFDELGKSRTDLKTL
CHHHCCCCCCCCCCC		38.3221440633
493PhosphorylationRKRQVKNSTNASVAG
CHHHHCCCCCCCHHC		19.8128889911
494PhosphorylationKRQVKNSTNASVAGN
HHHHCCCCCCCHHCC		44.1728889911
522PhosphorylationSTAQEPKSAEDSPSS
CCCCCCCCCCCCCCC		47.8322369663
526PhosphorylationEPKSAEDSPSSNGGT
CCCCCCCCCCCCCCE		20.4222369663
528PhosphorylationKSAEDSPSSNGGTVV
CCCCCCCCCCCCEEE		40.1522369663
529PhosphorylationSAEDSPSSNGGTVVK
CCCCCCCCCCCEEEE		42.7622369663
533PhosphorylationSPSSNGGTVVKGKVV
CCCCCCCEEEEEEEE		24.4322369663
546PhosphorylationVVNFGGFSARSLRSL
EEEECCCCHHHHHHH		26.5028889911
619UbiquitinationTEPVSGRKIIFLPTV
CCCCCCCEEEEECCC		43.6117644757
701PhosphorylationAISKKSTSVNVSDGK
HHHCCCCCEECCCCC		20.8430377154
705PhosphorylationKSTSVNVSDGKIKRR
CCCCEECCCCCEEEC		35.1330377154
755PhosphorylationRAVVVTKSIKNEIMW
HHHEECHHHCCHHCH		29.4528889911
766PhosphorylationEIMWDKITKLFPNNS
HHCHHHHHHHCCCCC		27.6928889911
773PhosphorylationTKLFPNNSLDNLKKK
HHHCCCCCHHHHHHH		43.6828889911
862PhosphorylationFTLVRDDTLTHSGND
EEEEECCCCCCCCCH		37.5327017623
873PhosphorylationSGNDLAMSSMIQREI
CCCHHHHHHHHHHHH		15.9027017623
892PhosphorylationKTYTRKISASTKDLS
HHHHHHCCCCCCCHH		21.1428889911
899PhosphorylationSASTKDLSKSQSDDY
CCCCCCHHHCCCCHH		40.1528889911
930UbiquitinationRNEIEALKNVGNESI
HHHHHHHHHCCCHHH		57.5517644757
936PhosphorylationLKNVGNESIDNVIMD
HHHCCCHHHHHHHHH		38.9628132839
973PhosphorylationILENRGNYKDFGVAF
HHHHCCCCCCCEEEE		18.1128889911
982PhosphorylationDFGVAFQYRCKVNEL
CCEEEEEEECCHHHH		16.1228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TFC3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TFC3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TFC3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TFC4_YEASTTFC4physical
9584160
TFC1_YEASTTFC1physical
9584160
TFC7_YEASTTFC7physical
9584160
TFC6_YEASTTFC6physical
9584160
FHL1_YEASTFHL1genetic
8083243
FBRL_YEASTNOP1genetic
8083243
TF3B_YEASTBRF1genetic
8083243
RPAB4_YEASTRPC10genetic
8083243
TBP_YEASTSPT15genetic
8083243
SRP40_YEASTSRP40genetic
8083243
TFC1_YEASTTFC1genetic
8083243
TFC4_YEASTTFC4genetic
8083243
TFC6_YEASTTFC6genetic
9418847
TFC1_YEASTTFC1physical
16554755
TFC6_YEASTTFC6physical
16554755
YRA1_YEASTYRA1physical
16554755
TFC4_YEASTTFC4physical
16554755
TFC7_YEASTTFC7physical
16554755
SUB1_YEASTSUB1physical
19706510
RL26A_YEASTRPL26Agenetic
19116144
RL6A_YEASTRPL6Agenetic
19116144
RL14A_YEASTRPL14Agenetic
19116144
TFC5_YEASTBDP1genetic
19116144
TF3B_YEASTBRF1genetic
19116144
TFC7_YEASTTFC7genetic
8617241
DED1_YEASTDED1genetic
10531351
RPAB4_YEASTRPC10genetic
10531351
TFC4_YEASTTFC4genetic
11459191
CDC48_YEASTCDC48genetic
27708008
COPA_YEASTCOP1genetic
27708008
COPB_YEASTSEC26genetic
27708008
RRP45_YEASTRRP45genetic
27708008
SRPR_YEASTSRP101genetic
27708008
NCS1_YEASTFRQ1genetic
27708008
ACT_YEASTACT1genetic
27708008
COPD_YEASTRET2genetic
27708008
YIP1_YEASTYIP1genetic
27708008
SYMC_YEASTMES1genetic
27708008
COFI_YEASTCOF1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
MON1_YEASTMON1genetic
27708008
LSM2_YEASTLSM2genetic
27708008
STU1_YEASTSTU1genetic
27708008
TFC1_YEASTTFC1genetic
27708008
CKS1_YEASTCKS1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
POP7_YEASTPOP7genetic
27708008
PRP5_YEASTPRP5genetic
27708008
CDC7_YEASTCDC7genetic
27708008
PRP11_YEASTPRP11genetic
27708008
KIN28_YEASTKIN28genetic
27708008
RPB1_YEASTRPO21genetic
27708008
FAL1_YEASTFAL1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
TPIS_YEASTTPI1genetic
27708008
DOP1_YEASTDOP1genetic
27708008
TFC6_YEASTTFC6genetic
27708008
SYF1_YEASTSYF1genetic
27708008
UTP6_YEASTUTP6genetic
27708008
TSC11_YEASTTSC11genetic
27708008
TBP_YEASTSPT15genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SAD1_YEASTSAD1genetic
27708008
SP105_YEASTSPC105genetic
27708008
PRP18_YEASTPRP18genetic
27708008
TFC4_YEASTTFC4genetic
27708008
PRP31_YEASTPRP31genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
GPI1_YEASTGPI1genetic
27708008
RPC9_YEASTRPC17genetic
27708008
DPB11_YEASTDPB11genetic
27708008
IF2A_YEASTSUI2genetic
27708008
ASK1_YEASTASK1genetic
27708008
CWC16_YEASTYJU2genetic
27708008
PRP19_YEASTPRP19genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CLF1_YEASTCLF1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
RU1C_YEASTYHC1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
CUS1_YEASTCUS1genetic
27708008
TRM6_YEASTGCD10genetic
27708008
CAP_YEASTSRV2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
DED1_YEASTDED1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
TFC8_YEASTTFC8genetic
27708008
SYLC_YEASTCDC60genetic
27708008
HRR25_YEASTHRR25genetic
27708008
PRP4_YEASTPRP4genetic
27708008
RPC3_YEASTRPC82genetic
27708008
PEX32_YEASTPEX32genetic
27708008
SLX5_YEASTSLX5genetic
27708008
UGA4_YEASTUGA4genetic
27708008
CWC15_YEASTCWC15genetic
27708008
ESC2_YEASTESC2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
STP1_YEASTSTP1genetic
27708008
YEW7_YEASTYER137Cgenetic
27708008
GLRX4_YEASTGRX4genetic
27708008
BUD27_YEASTBUD27genetic
27708008
GET1_YEASTGET1genetic
27708008
IST3_YEASTIST3genetic
27708008
DAL81_YEASTDAL81genetic
27708008
MDL1_YEASTMDL1genetic
27708008
YMP8_YEASTYMR018Wgenetic
27708008
YM49_YEASTYMR187Cgenetic
27708008
TOP1_YEASTTOP1genetic
27708008
ELOC_YEASTELC1genetic
27708008
ATG41_YEASTICY2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TFC3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546, AND MASSSPECTROMETRY.

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