SYF1_YEAST - dbPTM
SYF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYF1_YEAST
UniProt AC Q04048
Protein Name Pre-mRNA-splicing factor SYF1
Gene Name SYF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 859
Subcellular Localization Nucleus .
Protein Description Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation..
Protein Sequence MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAIEQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAELINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDNITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPDKWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHTLTQSTSSYSINPDEIELDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationEDYIRWESTKEVVET
HHHHCHHCHHHHHHH		37.5127017623
84PhosphorylationDYIRWESTKEVVETS
HHHCHHCHHHHHHHH		21.5127017623
546PhosphorylationFNSLRIWSKYIDYLE
HHHHHHHHHHHHHHH		17.1427017623
548PhosphorylationSLRIWSKYIDYLEAY
HHHHHHHHHHHHHHH		8.1027017623
551PhosphorylationIWSKYIDYLEAYCPK
HHHHHHHHHHHHCCC		9.2527017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ISY1_YEASTISY1physical
10688190
NTC20_YEASTNTC20physical
10688190
SYF2_YEASTSYF2physical
10688190
PRP19_YEASTPRP19physical
11842115
NTC20_YEASTNTC20physical
11842115
ISY1_YEASTISY1physical
11842115
SN309_YEASTSNT309physical
11842115
ISY1_YEASTISY1physical
11102353
SYF1_YEASTSYF1physical
11842115
PRP45_YEASTPRP45physical
16554755
YBY9_YEASTYBR139Wphysical
16554755
NTC20_YEASTNTC20physical
16554755
TPS2_YEASTTPS2physical
16554755
RV167_YEASTRVS167physical
16554755
SYF2_YEASTSYF2physical
16554755
PRP8_YEASTPRP8physical
16554755
SEC6_YEASTSEC6physical
16554755
ISY1_YEASTISY1physical
16554755
PRP19_YEASTPRP19physical
16554755
CLF1_YEASTCLF1physical
16554755
SMD3_YEASTSMD3physical
16554755
CEF1_YEASTCEF1physical
16554755
CLF1_YEASTCLF1physical
16429126
PRP8_YEASTPRP8physical
16429126
ISY1_YEASTISY1physical
10094305
HKR1_YEASTHKR1physical
18467557
DCPS_YEASTDCS1genetic
19061648
EFM7_YEASTNNT1genetic
19061648
YL287_YEASTYLR287Cgenetic
19061648
SAC3_YEASTSAC3genetic
19061648
MOG1_YEASTMOG1genetic
19061648
NRP1_YEASTNRP1genetic
19061648
CEF1_YEASTCEF1physical
19617314
CLF1_YEASTCLF1physical
19617314
SYF2_YEASTSYF2physical
19617314
ISY1_YEASTISY1physical
19617314
NTC20_YEASTNTC20physical
19617314
CWC16_YEASTYJU2physical
19617314
SYF2_YEASTSYF2genetic
19617314
NTC20_YEASTNTC20genetic
19617314
ISY1_YEASTISY1genetic
19617314
SN309_YEASTSNT309physical
19617314
SMD1_YEASTSMD1physical
19617314
PRP19_YEASTPRP19physical
19617314
HPR1_YEASTHPR1genetic
21576257
MFT1_YEASTMFT1genetic
21576257
RPB1_YEASTRPO21physical
21576257
HPR1_YEASTHPR1physical
21576257
PRP8_YEASTPRP8physical
21576257
BRR2_YEASTBRR2physical
21576257
SN114_YEASTSNU114physical
21576257
CEF1_YEASTCEF1physical
21576257
CLF1_YEASTCLF1physical
21576257
PRP19_YEASTPRP19physical
21576257
CWC16_YEASTYJU2physical
23438600
RS17A_YEASTRPS17Aphysical
27244240
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYF1_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory