HKR1_YEAST - dbPTM
HKR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HKR1_YEAST
UniProt AC P41809
Protein Name Signaling mucin HKR1
Gene Name HKR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1802
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta-glucan synthesis. Overexpression provides resistance to HM-1 killer toxin..
Protein Sequence MVSLKIKKILLLVSLLNAIEAYSNDTIYSTSYNNGIESTPSYSTSAISSTGSSNKENAITSSSETTTMAGQYGESGSTTIMDEQETGTSSQYISVTTTTQTSDTMSSVKKSTEIATPSSSIVPTPLQSYSDESQISQTLSHNPKSVAESDSDTTSSESSSSVIISTSDSSAVPREISPIITTDSQISKEEGTLAQTSSISETTRIAQMVTRVSQISSITAASTIDGFSSESTQTDFSNTVSFENSVEEEYAMSKSQLSESYSSSSTVYSGGESTADKTSSSPITSFSSSYSQTTSTETSESSRVAVGVSRPSSITQTTSIDSFSMSEVELSTYYDLSAGNYPDQELIVDRPATSSTAETSSEASQGVSRESNTFAVSSISTTNFIVSSASDTVVSTSSTNTVPYSSVHSTFVHATSSSTYISSSLYSSPSLSASVSSHFGVAPFPSAYISFSSVPVAVSSTYTSSPSASVVVPSAYASSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPVAISSTYTSSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSALVVLSSTSTSSPYDIVYSPSTFAAISSGYTPSPSASVAMSSTSSSSPYDIVYSLSSSASRSSIATYEFSPSPSTSLPTSSTYTYFSSAYAFEFSSERYSTTSTIAPTQIHSTLSRITDFLLQTSMAIQSIVSQQISTSSTLNDEIHSSALSVFNPSASNLVETSLIISSTQASITSPKNSAKISSLQSQLSSSTKNPYDTANKNTETSGRSTVVSNFLYTSSAAKPDNEKFSATPTEITTISSSSHAYSLSIPSSHNSVTGLSHNFVDSSKSATSFGYSSSSISSIKLSKETIPASKSVSNTQERITSFTSTLRANSQSEKSEGRNSVGSLQSSHISSNPSLSTNTKVDSKSLSRKVSKTMGENGEETGLTTTKTQYKSSSETSGSYSRSFTKISIGPATTAVQTQASTNSVFTAPALSTYPTTPYPSPNSYAWLPTAIIVESSETGPTTASFNPSITGSLPNAIEPAVAVSEPINHTLITIGFTAALNYVFLVQNPLSSAQIFNFLPLVLKYPFSNTSSELDNSIGELSTFILSYRSGSSTTTLSPKSISSLSVVKKKKNQQKKNATKSTEDLHPPQVDTSSIAVKKIVPMVDSSKAYIVSVAEVYFPTEAVTYLQQLILDENSTLYSNPQTPLRSLAGLIDSGIPLGGLTLYGSGDGGYVPSLTSSSVLDSSKGNSQNIDGTYKYGALDDFINSFTDSASAGKYAVKIIIFLIVLTIGVLLWLFVAFFAFRHRNILLKRHPRNCIGKSLNNERELESTELSRSSSGNQVYNEKPPESENESVYSAVDDHYIVTGENTVYNTIHRLHYTINDDGDLLYRDAIPLDFDQTNGDDGSGIDSIVRDCVYDKNQDATEAFLNDEESISGILDVDENGDIRLYDSYSDNEESNSFHLPDEVIENYNKNHLCETKLHGLGTESCTTDDPDTGNQITNEFSTGSQTCLPSTAYTTPLHTNSIKLHTLRYTESSLPKPNQTLFSNLEDLEIEDIDDNGSVSDVHIEELDALDEELYKRMSKVIKQQNHQTTKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MVSLKIKKIL
-----CCCHHHHHHH		35.4930377154
24N-linked_GlycosylationNAIEAYSNDTIYSTS
HHHHHHCCCCCEECC		37.46-
988PhosphorylationTETSGRSTVVSNFLY
CCCCCCCEEEEEEEE		24.4627017623
991PhosphorylationSGRSTVVSNFLYTSS
CCCCEEEEEEEEECC		19.9627017623
1126PhosphorylationSTNTKVDSKSLSRKV
CCCCCCCHHHHHHHH		27.4230377154
1128PhosphorylationNTKVDSKSLSRKVSK
CCCCCHHHHHHHHHH		35.2130377154
1130PhosphorylationKVDSKSLSRKVSKTM
CCCHHHHHHHHHHHH		36.8330377154
1252N-linked_GlycosylationVAVSEPINHTLITIG
EEECCCCCCCEEHHC		32.57-
1293N-linked_GlycosylationVLKYPFSNTSSELDN
HHHCCCCCCCHHHHC		44.34-
1342N-linked_GlycosylationKKNQQKKNATKSTED
HHCHHCCCCCCCCCC		60.93-
1400N-linked_GlycosylationQQLILDENSTLYSNP
HHHHHCCCCCCCCCC		39.70-
1472PhosphorylationALDDFINSFTDSASA
CHHHHHHHCCCCCCC		25.3830377154
1476PhosphorylationFINSFTDSASAGKYA
HHHHCCCCCCCHHHH		22.5130377154
1478PhosphorylationNSFTDSASAGKYAVK
HHCCCCCCCHHHHHH		41.3230377154
1525UbiquitinationHPRNCIGKSLNNERE
CCCCCCCHHCCCHHH		31.6823749301
1535PhosphorylationNNERELESTELSRSS
CCHHHHCCCEECCCC		39.5427214570
1612PhosphorylationQTNGDDGSGIDSIVR
CCCCCCCCCHHHHHH		39.3027214570
1616PhosphorylationDDGSGIDSIVRDCVY
CCCCCHHHHHHHHHC		22.5127214570
1657PhosphorylationGDIRLYDSYSDNEES
CCEEEEECCCCCCCC		16.9919779198
1659PhosphorylationIRLYDSYSDNEESNS
EEEEECCCCCCCCCC		37.6019779198
1664PhosphorylationSYSDNEESNSFHLPD
CCCCCCCCCCCCCCH		31.4319779198
1666PhosphorylationSDNEESNSFHLPDEV
CCCCCCCCCCCCHHH		24.2719779198
1716PhosphorylationEFSTGSQTCLPSTAY
CCCCCCCCCCCCCCC		20.0827738172
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HKR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HKR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HKR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DOT1_YEASTDOT1genetic
14764870
CDC26_YEASTCDC26genetic
14764870
EMP24_YEASTEMP24genetic
14764870
VPS24_YEASTVPS24genetic
14764870
SAM37_YEASTSAM37genetic
14764870
YTA12_YEASTYTA12genetic
14764870
MAS5_YEASTYDJ1genetic
14764870
IF2M_YEASTIFM1genetic
14764870
ARP8_YEASTARP8genetic
14764870
RTG3_YEASTRTG3genetic
20093466
YCQ6_YEASTYCR016Wgenetic
20093466
RIM1_YEASTRIM1genetic
20093466
RBSK_YEASTRBK1genetic
20093466
TPS2_YEASTTPS2genetic
20093466
PT122_YEASTPET122genetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
BCH1_YEASTBCH1genetic
20093466
COQ10_YEASTCOQ10genetic
20093466
YO08A_YEASTYOR008C-Agenetic
20093466
BUB3_YEASTBUB3genetic
20093466
VPS5_YEASTVPS5genetic
20093466
DGK1_YEASTDGK1genetic
20093466
MNN10_YEASTMNN10genetic
14764870
NSR1_YEASTNSR1genetic
14764870
BCK1_YEASTBCK1genetic
14764870
PKR1_YEASTPKR1genetic
14764870
DHE4_YEASTGDH1genetic
14764870
BEM4_YEASTBEM4genetic
14764870
HOG1_YEASTHOG1genetic
20932477
PBS2_YEASTPBS2genetic
20932477
STE11_YEASTSTE11genetic
20932477
STE50_YEASTSTE50genetic
20932477
OPY2_YEASTOPY2genetic
20932477
STE20_YEASTSTE20genetic
20932477
SAC1_YEASTSAC1genetic
20526336
LEM3_YEASTLEM3genetic
20526336
SLA1_YEASTSLA1genetic
20526336
RV161_YEASTRVS161genetic
20526336
FIMB_YEASTSAC6genetic
20526336
MID2_YEASTMID2genetic
20526336
MID1_YEASTMID1genetic
20526336
RTG3_YEASTRTG3genetic
20526336
KIN1_YEASTKIN1genetic
20526336
MKK1_YEASTMKK1genetic
20526336
SEM1_YEASTSEM1genetic
20526336
BEM1_YEASTBEM1genetic
24570489
RBSK_YEASTRBK1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
TPS2_YEASTTPS2genetic
27708008
PALF_YEASTRIM8genetic
27708008
MRM2_YEASTMRM2genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
VRP1_YEASTVRP1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
TOP1_YEASTTOP1genetic
27708008
BUB3_YEASTBUB3genetic
27708008
VPS5_YEASTVPS5genetic
27708008
RU2A_YEASTLEA1genetic
27708008
YD073_YEASTYDL073Wphysical
26787842
OPY2_YEASTOPY2physical
25898136
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HKR1_YEAST

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Related Literatures of Post-Translational Modification

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