| UniProt ID | YTA12_YEAST | |
|---|---|---|
| UniProt AC | P40341 | |
| Protein Name | Mitochondrial respiratory chain complexes assembly protein YTA12 | |
| Gene Name | YTA12 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 825 | |
| Subcellular Localization |
Mitochondrion membrane Multi-pass membrane protein . |
|
| Protein Description | Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides.. | |
| Protein Sequence | MLLLSWSRIATKVVRRPVRFRSYYGLTHIKSLHTQYRLLNRLQENKSGNKNEDNNEDAKLNKEIPTDEEVEAIRKQVEKYIEQTKNNTIPANWKEQKRKIDESIRRLEDAVLKQESNRIQEERKEKEEENGPSKAKSNRTKEQGYFEGNNSRNIPPPPPPPPPKPPLNDPSNPVSKNVNLFQIGLTFFLLSFLLDLLNSLEEQSEITWQDFREKLLAKGYVAKLIVVNKSMVKVMLNDNGKNQADNYGRNFYYFTIGSIDSFEHKLQKAQDELDIDKDFRIPVLYVQEGNWAKAMFQILPTVLMIAGIIWLTRRSAQAAGGSRGGIFGLSRSKAKKFNTETDVKIKFKDVAGCDEAKEEIMEFVSFLKEPSRYEKMGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRDLFKTARENAPSIVFIDEIDAIGKARQKGNFSGANDERENTLNQMLVEMDGFTPADHVVVLAGTNRPDILDKALLRPGRFDRHINIDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGADIANVCNEAALIAARSDEDAVKLNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWYLKYADPLLKVSIIPRGQGALGYAQYLPGDIFLLTEQQLKDRMTMSLGGRVSEELHFPSVTSGASDDFKKVTSMATAMVTELGMSDKIGWVNYQKRDDSDLTKPFSDETGDIIDSEVYRIVQECHDRCTKLLKEKAEDVEKIAQVLLKKEVLTREDMIDLLGKRPFPERNDAFDKYLNDYETEKIRKEEEKNEKRNEPKPSTN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 268 | Acetylation | SFEHKLQKAQDELDI HHHHHHHHHHHHCCC | 59.45 | 24489116 | |
| 330 | Phosphorylation | RGGIFGLSRSKAKKF CCCCCCCCHHHCCCC | 34.58 | 27214570 | |
| 394 | Ubiquitination | SGPPGTGKTLLAKAT CCCCCCCHHHHHHHH | 35.52 | 22817900 | |
| 399 | Ubiquitination | TGKTLLAKATAGEAG CCHHHHHHHHCCCCC | 46.36 | 22817900 | |
| 454 | Acetylation | DEIDAIGKARQKGNF EEHHHHHHHHHCCCC | 33.99 | 25381059 | |
| 518 | Ubiquitination | DRHINIDKPELEGRK CCCCCCCCHHHCCHH | 36.27 | 17644757 | |
| 518 | Acetylation | DRHINIDKPELEGRK CCCCCCCCHHHCCHH | 36.27 | 24489116 | |
| 525 | Ubiquitination | KPELEGRKAIFAVHL CHHHCCHHHEEEEEH | 57.60 | 17644757 | |
| 545 | Acetylation | AGEIFDLKNRLAALT HHHHCHHHHHHHHHC | 41.69 | 24489116 | |
| 580 | Acetylation | RSDEDAVKLNHFEQA CCCHHHHHCHHHHHH | 45.34 | 24489116 | |
| 737 | Phosphorylation | ETGDIIDSEVYRIVQ CCCCCCCHHHHHHHH | 20.67 | 27017623 | |
| 740 | Phosphorylation | DIIDSEVYRIVQECH CCCCHHHHHHHHHHH | 7.20 | 27017623 | |
| 797 | Acetylation | ERNDAFDKYLNDYET CCCHHHHHHHHHHHH | 45.22 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of YTA12_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of YTA12_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of YTA12_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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