| UniProt ID | AFG3_YEAST | |
|---|---|---|
| UniProt AC | P39925 | |
| Protein Name | Mitochondrial respiratory chain complexes assembly protein AFG3 | |
| Gene Name | AFG3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 761 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . |
|
| Protein Description | Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides.. | |
| Protein Sequence | MMMWQRYARGAPRSLTSLSFGKASRISTVKPVLRSRMPVHQRLQTLSGLATRNTIHRSTQIRSFHISWTRLNENRPNKEGEGKNNGNKDNNSNKEDGKDKRNEFGSLSEYFRSKEFANTMFLTIGFTIIFTLLTPSSNNSGDDSNRVLTFQDFKTKYLEKGLVSKIYVVNKFLVEAELVNTKQVVSFTIGSVDIFEEQMDQIQDLLNIPPRDRIPIKYIERSSPFTFLFPFLPTIILLGGLYFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNKETDIKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKGGALGGANDEREATLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVNGRQQIYLVHLKRLNLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHHFEQAIERVIAGLEKKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLLKVSIIPRGQGALGYAQYLPPDQYLISEEQFRHRMIMALGGRVSEELHFPSVTSGAHDDFKKVTQMANAMVTSLGMSPKIGYLSFDQNDGNFKVNKPFSNKTARTIDLEVKSIVDDAHRACTELLTKNLDKVDLVAKELLRKEAITREDMIRLLGPRPFKERNEAFEKYLDPKSNTEPPEAPAATN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 281 | Phosphorylation | AKLFNKETDIKISFK HHHCCCCCCCEEEEE | 44.63 | 19823750 | |
| 286 | Phosphorylation | KETDIKISFKNVAGC CCCCCEEEEECCCCC | 25.76 | 19823750 | |
| 334 | Ubiquitination | SGPPGTGKTLLAKAT CCCCCCCHHHHHHHC | 35.52 | 22817900 | |
| 339 | Ubiquitination | TGKTLLAKATAGEAN CCHHHHHHHCCCCCC | 46.36 | 22817900 | |
| 577 | Acetylation | KYADPLLKVSIIPRG HHCCCCEEEEEEECC | 41.44 | 24489116 | |
| 647 | Phosphorylation | QMANAMVTSLGMSPK HHHHHHHHHCCCCCC | 12.73 | 29688323 | |
| 648 | Phosphorylation | MANAMVTSLGMSPKI HHHHHHHHCCCCCCE | 16.12 | 29688323 | |
| 652 | Phosphorylation | MVTSLGMSPKIGYLS HHHHCCCCCCEEEEE | 22.65 | 29688323 | |
| 706 | Acetylation | LLTKNLDKVDLVAKE HHHCCCCHHHHHHHH | 40.59 | 24489116 | |
| 712 | Acetylation | DKVDLVAKELLRKEA CHHHHHHHHHHHHHC | 41.22 | 24489116 | |
| 743 | Acetylation | ERNEAFEKYLDPKSN HHHHHHHHHCCCCCC | 44.66 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AFG3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AFG3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AFG3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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