MIC26_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC26_YEAST
• UniProt AC: P50087
• Protein Name: MICOS subunit MIC26
• Gene Name: MIC26
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 233
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein . Enriched at crista junctions.
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane..
• Protein Sequence: MTKDFYRQLDPVEEKIVPPENAIVISSEAKEATVNEKEAKQGVLSQRVMKYIGENELVDGISVRDPDYLKRFFNERRKQFSAKWDKVTNKIDDIAGRYYAREESFTSTIASLHTDPNERLIPGLLSILVASMTGSVLARRRTWLLRATMPIILGSCCFAYAMPTTFRNTMGLIHNLEMNTFPHFTERQDRVWKETKRLSTASVQYYYDAKKWLNKDVEKTGNAIKNWTGVNVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	QLDPVEEKIVPPENA HCCCCCCCCCCCCCE		24489116
33	Phosphorylation	SSEAKEATVNEKEAK ECCHHCCCCCHHHHH		21126336
219	Acetylation	WLNKDVEKTGNAIKN HHCCCHHHHCCHHHH		24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIC26_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC26_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC26_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIC60_YEAST	MIC60	physical	22009199
MIC10_YEAST	MIC10	physical	22009199
MIC19_YEAST	MIC19	physical	22009199
MIC27_YEAST	MIC27	physical	22009199
MIC12_YEAST	MIC12	physical	22009199
MIC27_YEAST	MIC27	physical	21987634
MIC10_YEAST	MIC10	physical	21987634
MIC60_YEAST	MIC60	physical	21987634
MIC19_YEAST	MIC19	physical	21987634
HSP72_YEAST	SSA2	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
RRP5_YEAST	RRP5	physical	22940862
PYR1_YEAST	URA2	physical	22940862
MIC60_YEAST	MIC60	physical	22918945
MIC10_YEAST	MIC10	physical	22918945
MIC27_YEAST	MIC27	physical	22918945
MIC19_YEAST	MIC19	physical	22918945
MIC12_YEAST	MIC12	physical	22918945
SAM50_YEAST	SAM50	physical	22918945
SLX5_YEAST	SLX5	genetic	27708008
LSB3_YEAST	LSB3	genetic	27708008
YGZ2_YEAST	YGL242C	genetic	27708008
YMS4_YEAST	YMR034C	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.