| UniProt ID | LSB3_YEAST | |
|---|---|---|
| UniProt AC | P43603 | |
| Protein Name | LAS seventeen-binding protein 3 | |
| Gene Name | LSB3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 459 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | ||
| Protein Sequence | MGINNPIPRSLKSETKKAAKILASFVKPNQVFGADQVIPPDVLKRAKGLAIITILKAGFLFSGRAGSGVIVARLKDGTWSAPSAIAMAGAGAGGMVGIELTDFVFILNTQDAVKSFSEFGTITLGGNVSVSAGPLGRSAEAAASASAGGVAAVFAYSKSKGLFAGVSVEGSAIIERREANRKFYGDNCTAKMILSGRIRPPPAVDPLFRVLESRAFNYRPSNGGRGSFDDDEDDYYDDDDYYNDIPSSFSSTDASSTRPNTRSTRRRAQSGSRYTFDDDDDDDDYGTGYSRNSRLAPTNSGGSGGKLDDPSGASSYYASHRRSGTAQSRARSSRNRWADDEYDDYDDDYESGYRRGNGRDRTKDREVDDLSNRFSKSRISSASTPQTSQGRFTAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 62 | Phosphorylation | LKAGFLFSGRAGSGV EECCEECCCCCCCCE | 29.53 | 28889911 | |
| 146 | Phosphorylation | AEAAASASAGGVAAV HHHHHHHHHCCCEEE | 25.58 | 19779198 | |
| 156 | Phosphorylation | GVAAVFAYSKSKGLF CCEEEEEEECCCCEE | 12.74 | 19779198 | |
| 157 | Phosphorylation | VAAVFAYSKSKGLFA CEEEEEEECCCCEEE | 27.33 | 19779198 | |
| 158 | Ubiquitination | AAVFAYSKSKGLFAG EEEEEEECCCCEEEE | 43.44 | 17644757 | |
| 221 | Phosphorylation | RAFNYRPSNGGRGSF HHCCCCCCCCCCCCC | 38.82 | 27017623 | |
| 227 | Phosphorylation | PSNGGRGSFDDDEDD CCCCCCCCCCCCCCC | 24.92 | 28889911 | |
| 235 | Phosphorylation | FDDDEDDYYDDDDYY CCCCCCCCCCCCCCC | 22.55 | 19779198 | |
| 236 | Phosphorylation | DDDEDDYYDDDDYYN CCCCCCCCCCCCCCC | 21.64 | 19779198 | |
| 241 | Phosphorylation | DYYDDDDYYNDIPSS CCCCCCCCCCCCCCC | 15.91 | 19779198 | |
| 242 | Phosphorylation | YYDDDDYYNDIPSSF CCCCCCCCCCCCCCC | 17.22 | 22369663 | |
| 247 | Phosphorylation | DYYNDIPSSFSSTDA CCCCCCCCCCCCCCC | 44.33 | 22369663 | |
| 248 | Phosphorylation | YYNDIPSSFSSTDAS CCCCCCCCCCCCCCC | 24.64 | 22369663 | |
| 250 | Phosphorylation | NDIPSSFSSTDASST CCCCCCCCCCCCCCC | 33.99 | 22369663 | |
| 251 | Phosphorylation | DIPSSFSSTDASSTR CCCCCCCCCCCCCCC | 28.44 | 22369663 | |
| 252 | Phosphorylation | IPSSFSSTDASSTRP CCCCCCCCCCCCCCC | 34.09 | 22369663 | |
| 255 | Phosphorylation | SFSSTDASSTRPNTR CCCCCCCCCCCCCCH | 34.74 | 22369663 | |
| 256 | Phosphorylation | FSSTDASSTRPNTRS CCCCCCCCCCCCCHH | 30.10 | 22369663 | |
| 257 | Phosphorylation | SSTDASSTRPNTRST CCCCCCCCCCCCHHH | 47.88 | 22369663 | |
| 261 | Phosphorylation | ASSTRPNTRSTRRRA CCCCCCCCHHHHHHC | 28.78 | 22369663 | |
| 263 | Phosphorylation | STRPNTRSTRRRAQS CCCCCCHHHHHHCCC | 24.99 | 28889911 | |
| 264 | Phosphorylation | TRPNTRSTRRRAQSG CCCCCHHHHHHCCCC | 25.55 | 17563356 | |
| 270 | Phosphorylation | STRRRAQSGSRYTFD HHHHHCCCCCCCCCC | 37.44 | 22369663 | |
| 272 | Phosphorylation | RRRAQSGSRYTFDDD HHHCCCCCCCCCCCC | 27.62 | 22369663 | |
| 274 | Phosphorylation | RAQSGSRYTFDDDDD HCCCCCCCCCCCCCC | 17.29 | 22369663 | |
| 275 | Phosphorylation | AQSGSRYTFDDDDDD CCCCCCCCCCCCCCC | 21.34 | 22369663 | |
| 285 | Phosphorylation | DDDDDDDYGTGYSRN CCCCCCCCCCCCCCC | 24.47 | 23749301 | |
| 287 | Phosphorylation | DDDDDYGTGYSRNSR CCCCCCCCCCCCCCC | 27.07 | 28889911 | |
| 289 | Phosphorylation | DDDYGTGYSRNSRLA CCCCCCCCCCCCCCC | 12.32 | 28889911 | |
| 290 | Phosphorylation | DDYGTGYSRNSRLAP CCCCCCCCCCCCCCC | 26.74 | 28889911 | |
| 298 | Phosphorylation | RNSRLAPTNSGGSGG CCCCCCCCCCCCCCC | 36.09 | 22369663 | |
| 300 | Phosphorylation | SRLAPTNSGGSGGKL CCCCCCCCCCCCCCC | 47.19 | 22369663 | |
| 303 | Phosphorylation | APTNSGGSGGKLDDP CCCCCCCCCCCCCCC | 48.15 | 22369663 | |
| 306 | Acetylation | NSGGSGGKLDDPSGA CCCCCCCCCCCCCCC | 52.87 | 24489116 | |
| 306 | Ubiquitination | NSGGSGGKLDDPSGA CCCCCCCCCCCCCCC | 52.87 | 23749301 | |
| 311 | Phosphorylation | GGKLDDPSGASSYYA CCCCCCCCCCCCHHH | 54.72 | 22890988 | |
| 314 | Phosphorylation | LDDPSGASSYYASHR CCCCCCCCCHHHHHC | 23.54 | 22890988 | |
| 315 | Phosphorylation | DDPSGASSYYASHRR CCCCCCCCHHHHHCC | 22.94 | 22890988 | |
| 316 | Phosphorylation | DPSGASSYYASHRRS CCCCCCCHHHHHCCC | 10.68 | 22890988 | |
| 317 | Phosphorylation | PSGASSYYASHRRSG CCCCCCHHHHHCCCC | 11.99 | 22890988 | |
| 319 | Phosphorylation | GASSYYASHRRSGTA CCCCHHHHHCCCCCH | 11.04 | 22890988 | |
| 351 | Phosphorylation | DYDDDYESGYRRGNG CCCCCHHHCCCCCCC | 34.59 | 28889911 | |
| 363 | Ubiquitination | GNGRDRTKDREVDDL CCCCCCCCCHHHHHH | 56.53 | 22817900 | |
| 371 | Phosphorylation | DREVDDLSNRFSKSR CHHHHHHHHHCCHHH | 32.71 | 25521595 | |
| 375 | Phosphorylation | DDLSNRFSKSRISSA HHHHHHCCHHHCCCC | 26.87 | 19823750 | |
| 377 | Phosphorylation | LSNRFSKSRISSAST HHHHCCHHHCCCCCC | 33.38 | 22369663 | |
| 380 | Phosphorylation | RFSKSRISSASTPQT HCCHHHCCCCCCCCC | 20.81 | 22369663 | |
| 381 | Phosphorylation | FSKSRISSASTPQTS CCHHHCCCCCCCCCC | 24.70 | 22369663 | |
| 383 | Phosphorylation | KSRISSASTPQTSQG HHHCCCCCCCCCCCC | 42.44 | 22369663 | |
| 384 | Phosphorylation | SRISSASTPQTSQGR HHCCCCCCCCCCCCC | 21.09 | 22369663 | |
| 387 | Phosphorylation | SSASTPQTSQGRFTA CCCCCCCCCCCCCCC | 24.99 | 22369663 | |
| 388 | Phosphorylation | SASTPQTSQGRFTAP CCCCCCCCCCCCCCC | 25.95 | 22369663 | |
| 393 | Phosphorylation | QTSQGRFTAPTSPST CCCCCCCCCCCCCCC | 30.30 | 22369663 | |
| 396 | Phosphorylation | QGRFTAPTSPSTSSP CCCCCCCCCCCCCCC | 51.29 | 22369663 | |
| 397 | Phosphorylation | GRFTAPTSPSTSSPK CCCCCCCCCCCCCCC | 18.78 | 22369663 | |
| 399 | Phosphorylation | FTAPTSPSTSSPKAV CCCCCCCCCCCCCEE | 40.46 | 22369663 | |
| 400 | Phosphorylation | TAPTSPSTSSPKAVA CCCCCCCCCCCCEEE | 36.29 | 22369663 | |
| 401 | Phosphorylation | APTSPSTSSPKAVAL CCCCCCCCCCCEEEE | 49.32 | 22369663 | |
| 402 | Phosphorylation | PTSPSTSSPKAVALY CCCCCCCCCCEEEEE | 30.43 | 22369663 | |
| 410 | Phosphorylation | PKAVALYSFAGEESG CCEEEEEEECCCCCC | 14.96 | 28889911 | |
| 416 | Phosphorylation | YSFAGEESGDLPFRK EEECCCCCCCCCCCC | 33.05 | 27214570 | |
| 428 | Phosphorylation | FRKGDVITILKKSDS CCCCCEEEEEECCCC | 21.80 | 21551504 | |
| 433 | Phosphorylation | VITILKKSDSQNDWW EEEEEECCCCCCCCC | 40.69 | 19779198 | |
| 435 | Phosphorylation | TILKKSDSQNDWWTG EEEECCCCCCCCCEE | 37.66 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LSB3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 397 | S | Phosphorylation |
| 19779198 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LSB3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; SER-303; THR-393;THR-396; SER-397; SER-399; SER-401; SER-402; SER-410 AND SER-416, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; SER-272; THR-275;SER-300 AND SER-303, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; SER-303; THR-393AND SER-402, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303 AND SER-397, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300 AND SER-303, ANDMASS SPECTROMETRY. | |
