| UniProt ID | SSK2_YEAST | |
|---|---|---|
| UniProt AC | P53599 | |
| Protein Name | MAP kinase kinase kinase SSK2 | |
| Gene Name | SSK2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1579 | |
| Subcellular Localization | ||
| Protein Description | Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.. | |
| Protein Sequence | MSHSDYFNYKPYGDSTEKPSSSKMRQSSSSSSSRLRSESLGRNSNTTQARVASSPISPGLHSTQYFRSPNAVYSPGESPLNTVQLFNRLPGIPQGQFFHQNAISGSSSSSARSSRRPSNIGLPLPKNPQQSLPKLSTQPVPVHKKVEASKTESEIIKKPAPVNSNQDPLLTTPTLVISPELASLNTTNTSIMSTPQNITNQTSNKHIPTRSQPNGSTSSSTLQDIVTTNSSQRSVGHHGGSTTSLRTYKKQYVLNEQLYLRKMRNRANDDYYTRGIVASSNFEDDEENFSNKGEDDLELEMDDLLKVEGEDKDNDFNFGYNFITSSTKNNENVVSMSLNYLKGKLDWLRDVNNDQPCEIEDEEWHSILGSEDLLSKLLQNPMVNNRFEWQTMLSKVLKGDIVRNEKTKIANQGKGPGFNTQFSDDIWIELKAWMNGRTVEDQNKSLRIFRDSTDSVFQEIMAFKLEDNMSADEAAETIKSLVDKYYRVLNLWPNIKRMHAEKPITKTEAFRNRIDTLNSWLNFKFNFDTNIAYLKKWIVGNKELESTTEVDNTTVNLDDPAVFATNCKRFAEQIMKEKDIELIFQKKIFFPLAPWILKAKFFFLKYQKTWNELNLSYLDQDLEFLLMFPMRLVKDIILIRLSYAKKIQNPTLMMIDQMMDDFSTYIKLAVQMKFTVASYCNDWFFKVKIDPEFDHTVVEGLEYFFSILELRILYSGKNSFKTSKEPDLLLKYWEMFRNVGYYIDDAGELIAAEFTKLTLRLVHRLHAYLLRQQNTPPKLENEAAAEKWLVQIFEILGSMKRKLNRFTNILTKAFQNFVRYKIEDHNYLLKQLKETGHFLIYTGGYLEQNGTYLIGSPELLGCKDDDILRIIKNSDIGCDLVPKLEINNSLTIYNALDDNWNSNSSLGSDISNDGTPFYYIKNDLTTQPRSYNGNRVNREPDFENSRSTEEEFYELETRLNSLGYVLVLTPQEPLLWEGEMYNLSDNKTIKPEGLNLKVIPNSIDLMCQGSSYALEYQCDRFQQISGSSVSFLEKKSSSETVKNNLQRINKAYFRCTYSVLKNYTKIVTTFKKVSPVNDLLNNIFLFGRDFGLNFLRINVANNEKRSIIILLMMRLSIGWLKFLAEDCDPTDQRVFRWCVTSMEFAMHMVSGWNILALDECQFSSLKQKISECMSLLISHFDIIGARSIEVEKINQQARSNLDLEDVFDDDMMLQVNSEFRVQSIMELEERIKRNPHQTGKVIDDSDKGNKYLVSLASSISNVSMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTHVSDSKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNEWAIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELLMDPWIVQIREIAFGDDSSSTDTEERE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSHSDYFNY ------CCHHHCCCC | 42.90 | 24961812 | |
| 4 | Phosphorylation | ----MSHSDYFNYKP ----CCHHHCCCCCC | 43.21 | 24961812 | |
| 6 | Phosphorylation | --MSHSDYFNYKPYG --CCHHHCCCCCCCC | 9.20 | 24961812 | |
| 16 | Phosphorylation | YKPYGDSTEKPSSSK CCCCCCCCCCCCCHH | 53.41 | 27017623 | |
| 37 | Phosphorylation | SSSSRLRSESLGRNS CCHHHHHHHHCCCCC | 35.81 | 22369663 | |
| 39 | Phosphorylation | SSRLRSESLGRNSNT HHHHHHHHCCCCCCC | 37.05 | 22369663 | |
| 44 | Phosphorylation | SESLGRNSNTTQARV HHHCCCCCCCCHHHH | 33.90 | 22369663 | |
| 46 | Phosphorylation | SLGRNSNTTQARVAS HCCCCCCCCHHHHHC | 21.80 | 22369663 | |
| 47 | Phosphorylation | LGRNSNTTQARVASS CCCCCCCCHHHHHCC | 25.20 | 22369663 | |
| 53 | Phosphorylation | TTQARVASSPISPGL CCHHHHHCCCCCCCC | 33.52 | 22369663 | |
| 54 | Phosphorylation | TQARVASSPISPGLH CHHHHHCCCCCCCCC | 19.26 | 22369663 | |
| 57 | Phosphorylation | RVASSPISPGLHSTQ HHHCCCCCCCCCCCC | 19.12 | 22369663 | |
| 62 | Phosphorylation | PISPGLHSTQYFRSP CCCCCCCCCCCCCCC | 23.42 | 22369663 | |
| 63 | Phosphorylation | ISPGLHSTQYFRSPN CCCCCCCCCCCCCCC | 19.28 | 22369663 | |
| 65 | Phosphorylation | PGLHSTQYFRSPNAV CCCCCCCCCCCCCCE | 10.88 | 22369663 | |
| 68 | Phosphorylation | HSTQYFRSPNAVYSP CCCCCCCCCCCEECC | 16.77 | 27017623 | |
| 73 | Phosphorylation | FRSPNAVYSPGESPL CCCCCCEECCCCCCC | 13.51 | 23749301 | |
| 74 | Phosphorylation | RSPNAVYSPGESPLN CCCCCEECCCCCCCC | 21.60 | 23749301 | |
| 78 | Phosphorylation | AVYSPGESPLNTVQL CEECCCCCCCCHHHH | 40.37 | 25752575 | |
| 82 | Phosphorylation | PGESPLNTVQLFNRL CCCCCCCHHHHHHCC | 19.81 | 28889911 | |
| 104 | Phosphorylation | FFHQNAISGSSSSSA EECCCCCCCCCCCCC | 30.16 | 19779198 | |
| 106 | Phosphorylation | HQNAISGSSSSSARS CCCCCCCCCCCCCCC | 21.91 | 23749301 | |
| 108 | Phosphorylation | NAISGSSSSSARSSR CCCCCCCCCCCCCCC | 29.97 | 19779198 | |
| 109 | Phosphorylation | AISGSSSSSARSSRR CCCCCCCCCCCCCCC | 29.93 | 19779198 | |
| 110 | Phosphorylation | ISGSSSSSARSSRRP CCCCCCCCCCCCCCC | 29.65 | 23749301 | |
| 118 | Phosphorylation | ARSSRRPSNIGLPLP CCCCCCCCCCCCCCC | 38.99 | 17330950 | |
| 131 | Phosphorylation | LPKNPQQSLPKLSTQ CCCCCCCCCCCCCCC | 41.20 | 22369663 | |
| 149 | Phosphorylation | VHKKVEASKTESEII CCCCCCCCCCHHHHH | 26.97 | 30377154 | |
| 153 | Phosphorylation | VEASKTESEIIKKPA CCCCCCHHHHHCCCC | 39.05 | 30377154 | |
| 211 | Phosphorylation | NKHIPTRSQPNGSTS CCCCCCCCCCCCCCC | 53.09 | 28889911 | |
| 217 | Phosphorylation | RSQPNGSTSSSTLQD CCCCCCCCCCCCHHH | 33.74 | 27017623 | |
| 218 | Phosphorylation | SQPNGSTSSSTLQDI CCCCCCCCCCCHHHH | 24.80 | 27017623 | |
| 231 | Phosphorylation | DIVTTNSSQRSVGHH HHHHCCCCCCCCCCC | 31.51 | 23749301 | |
| 234 | Phosphorylation | TTNSSQRSVGHHGGS HCCCCCCCCCCCCCC | 25.47 | 29136822 | |
| 241 | Phosphorylation | SVGHHGGSTTSLRTY CCCCCCCCCCCHHHH | 32.86 | 21440633 | |
| 243 | Phosphorylation | GHHGGSTTSLRTYKK CCCCCCCCCHHHHHH | 27.71 | 29136822 | |
| 272 | Phosphorylation | NRANDDYYTRGIVAS HHCCCCCCCCCEEEC | 9.28 | 27017623 | |
| 273 | Phosphorylation | RANDDYYTRGIVASS HCCCCCCCCCEEECC | 19.05 | 27017623 | |
| 290 | Phosphorylation | EDDEENFSNKGEDDL CCCCHHCCCCCCCCE | 49.57 | 28889911 | |
| 326 | Phosphorylation | GYNFITSSTKNNENV CEEEEECCCCCCCCE | 34.45 | 27017623 | |
| 327 | Phosphorylation | YNFITSSTKNNENVV EEEEECCCCCCCCEE | 37.24 | 27017623 | |
| 337 | Phosphorylation | NENVVSMSLNYLKGK CCCEEEEEHHHHHHC | 13.12 | 27017623 | |
| 651 | Phosphorylation | AKKIQNPTLMMIDQM HHHCCCCEEHHHHHH | 34.53 | 28889911 | |
| 663 | Phosphorylation | DQMMDDFSTYIKLAV HHHHHHHHHHHHHHH | 27.56 | 27017623 | |
| 664 | Phosphorylation | QMMDDFSTYIKLAVQ HHHHHHHHHHHHHHH | 29.29 | 27017623 | |
| 714 | Phosphorylation | ILELRILYSGKNSFK HHHHHHHHCCCCCCC | 17.01 | 21440633 | |
| 722 | Phosphorylation | SGKNSFKTSKEPDLL CCCCCCCCCCCHHHH | 42.91 | 27017623 | |
| 775 | Phosphorylation | YLLRQQNTPPKLENE HHHHCCCCCCCCCCH | 36.31 | 28889911 | |
| 820 | Phosphorylation | AFQNFVRYKIEDHNY HHHHHHHHHCCCCCH | 15.83 | 25533186 | |
| 905 | Phosphorylation | DNWNSNSSLGSDISN CCCCCCCCCCCCCCC | 40.79 | 19779198 | |
| 908 | Phosphorylation | NSNSSLGSDISNDGT CCCCCCCCCCCCCCC | 36.74 | 19779198 | |
| 911 | Phosphorylation | SSLGSDISNDGTPFY CCCCCCCCCCCCCEE | 33.58 | 19779198 | |
| 947 | Phosphorylation | PDFENSRSTEEEFYE CCCCCCCCCHHHHHH | 39.74 | 28889911 | |
| 1251 | Phosphorylation | DSDKGNKYLVSLASS CCCCCCEEEHHHHHH | 19.14 | 28889911 | |
| 1257 | Phosphorylation | KYLVSLASSISNVSM EEEHHHHHHHCCCCH | 33.23 | 28889911 | |
| 1258 | Phosphorylation | YLVSLASSISNVSMR EEHHHHHHHCCCCHH | 25.16 | 28889911 | |
| 1282 | Phosphorylation | GTFGRVYSAVDLDNG CCCCCEEEEEECCCC | 20.96 | 28889911 | |
| 1307 | Ubiquitination | QDSKSMQKIFPLIKE CCCHHHHHHHHHHHH | 37.36 | 17644757 | |
| 1313 | Ubiquitination | QKIFPLIKEEMSVLE HHHHHHHHHHHCHHH | 56.13 | 17644757 | |
| 1420 | Phosphorylation | KKIANNGTRLASMNK HHHCCCCCCEEECCC | 25.32 | 20377248 | |
| 1424 | Phosphorylation | NNGTRLASMNKIENA CCCCCEEECCCCCCC | 27.72 | 20377248 | |
| 1439 | Phosphorylation | DGEHEDVTHVSDSKA CCCCCCCCCCCCCHH | 28.96 | 21551504 | |
| 1442 | Phosphorylation | HEDVTHVSDSKAVKN CCCCCCCCCCHHHHC | 28.67 | 28889911 | |
| 1444 | Phosphorylation | DVTHVSDSKAVKNNE CCCCCCCCHHHHCCC | 18.27 | 21551504 | |
| 1460 | Phosphorylation | ALLDMMGTPMYMAPE HHHHHCCCCCEECCH | 6.23 | 28889911 | |
| 1468 | Phosphorylation | PMYMAPESITGSTTK CCEECCHHCCCCCCC | 25.13 | 28889911 | |
| 1474 | Phosphorylation | ESITGSTTKGKLGAD HHCCCCCCCCCCCHH | 39.22 | 28889911 | |
| 1570 | Phosphorylation | EIAFGDDSSSTDTEE EHHHCCCCCCCCCCC | 30.81 | 22369663 | |
| 1571 | Phosphorylation | IAFGDDSSSTDTEER HHHCCCCCCCCCCCC | 44.23 | 22369663 | |
| 1572 | Phosphorylation | AFGDDSSSTDTEERE HHCCCCCCCCCCCCC | 33.96 | 22369663 | |
| 1573 | Phosphorylation | FGDDSSSTDTEERE- HCCCCCCCCCCCCC- | 49.22 | 22369663 | |
| 1575 | Phosphorylation | DDSSSTDTEERE--- CCCCCCCCCCCC--- | 39.57 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SSK2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SSK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SSK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54; SER-57; SER-74;SER-78; THR-82; SER-118 AND SER-290, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND MASSSPECTROMETRY. | |
