YAP3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YAP3_YEAST
• UniProt AC: P38749
• Protein Name: AP-1-like transcription factor YAP3
• Gene Name: YAP3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 330
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity). Preferentially binds 5'-TTACTAA-3'..
• Protein Sequence: MTPSNMDDNTSGFMKFINPQCQEEDCCIRNSLFQEDSKCIKQQPDLLSEQTAPFPILEDQCPALNLDRSNNDLLLQNNISFPKGSDLQAIQLTPISGDYSTYVMADNNNNDNDSYSNTNYFSKNNGISPSSRSPSVAHNENVPDDSKAKKKAQNRAAQKAFRERKEARMKELQDKLLESERNRQSLLKEIEELRKANTEINAENRLLLRSGNENFSKDIEDDTNYKYSFPTKDEFFTSMVLESKLNHKGKYSLKDNEIMKRNTQYTDEAGRHVLTVPATWEYLYKLSEERDFDVTYVMSKLQGQECCHTHGPAYPRSLIDFLVEEATLNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTPSNMDDN ------CCCCCCCCC	35.11	22369663
4	Phosphorylation	----MTPSNMDDNTS ----CCCCCCCCCCC	35.30	22369663
10	Phosphorylation	PSNMDDNTSGFMKFI CCCCCCCCCCCHHHC	36.90	21551504
128	Phosphorylation	FSKNNGISPSSRSPS HHCCCCCCCCCCCCC	21.81	22369663
130	Phosphorylation	KNNGISPSSRSPSVA CCCCCCCCCCCCCCC	31.43	22369663
131	Phosphorylation	NNGISPSSRSPSVAH CCCCCCCCCCCCCCC	39.91	22369663
133	Phosphorylation	GISPSSRSPSVAHNE CCCCCCCCCCCCCCC	24.39	22369663
135	Phosphorylation	SPSSRSPSVAHNENV CCCCCCCCCCCCCCC	32.93	22369663
146	Phosphorylation	NENVPDDSKAKKKAQ CCCCCCHHHHHHHHH	41.72	22369663
210	Phosphorylation	ENRLLLRSGNENFSK HHHHEEECCCCCCCC	46.04	30377154
223	Phosphorylation	SKDIEDDTNYKYSFP CCCCCCCCCCCCCCC	53.41	21440633
231	Phosphorylation	NYKYSFPTKDEFFTS CCCCCCCCHHHHHHH	49.47	21440633
260	Acetylation	LKDNEIMKRNTQYTD CCCCHHHHHHCCCCC	48.43	25381059
317	Phosphorylation	HGPAYPRSLIDFLVE CCCCCCHHHHHHHHH	25.77	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YAP3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YAP3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YAP3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGD1_YEAST	SGD1	physical	18467557
SSB1_YEAST	SSB1	physical	19536198
BUB1_YEAST	BUB1	genetic	21127252
PPS1_YEAST	PPS1	genetic	21127252
ADA2_YEAST	ADA2	genetic	21127252
RPN4_YEAST	RPN4	genetic	21127252
MED5_YEAST	NUT1	genetic	21127252
SERB_YEAST	SER2	genetic	21127252
PPZ2_YEAST	PPZ2	genetic	21127252
TECR_YEAST	TSC13	genetic	27708008
SEC7_YEAST	SEC7	genetic	27708008
SDA1_YEAST	SDA1	genetic	27708008
NTR2_YEAST	NTR2	genetic	27708008
RPF2_YEAST	RPF2	genetic	27708008
NUF2_YEAST	NUF2	genetic	27708008
LEU1_YEAST	LEU4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2; SER-128 AND SER-133,AND MASS SPECTROMETRY.
PubMed: 18407956