LEU1_YEAST - dbPTM
LEU1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LEU1_YEAST
UniProt AC P06208
Protein Name 2-isopropylmalate synthase
Gene Name LEU4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 619
Subcellular Localization Isoform Cytoplasmic: Cytoplasm.
Isoform Mitochondrial: Mitochondrion.
Protein Description Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)..
Protein Sequence MVKESIIALAEHAASRASRVIPPVKLAYKNMLKDPSSKYKPFNAPKLSNRKWPDNRITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNYNDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATINNIIHSGDVSIPSLAEVEGKNAAASGSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25AcetylationSRVIPPVKLAYKNML
HHCCCHHHHHHHHCC		32.9224489116
29AcetylationPPVKLAYKNMLKDPS
CHHHHHHHHCCCCCH		30.2124489116
33AcetylationLAYKNMLKDPSSKYK
HHHHHCCCCCHHCCC		57.7524489116
36PhosphorylationKNMLKDPSSKYKPFN
HHCCCCCHHCCCCCC		49.9819823750
37PhosphorylationNMLKDPSSKYKPFNA
HCCCCCHHCCCCCCC		45.4519823750
39PhosphorylationLKDPSSKYKPFNAPK
CCCCHHCCCCCCCCC		26.3319823750
40AcetylationKDPSSKYKPFNAPKL
CCCHHCCCCCCCCCC		47.0422865919
46AcetylationYKPFNAPKLSNRKWP
CCCCCCCCCCCCCCC		63.2424489116
48PhosphorylationPFNAPKLSNRKWPDN
CCCCCCCCCCCCCCC		40.4919795423
74PhosphorylationDLRDGNQSLPDPMSV
CCCCCCCCCCCCCCH		45.9625704821
90AcetylationQKKEYFHKLVNIGFK
HHHHHHHHHHHCCCE		44.2022865919
107PhosphorylationEVSFPSASQTDFDFT
EEECCCCCCCCCCCH		37.6427214570
178AcetylationSREEAISKAVEATKL
CHHHHHHHHHHHHHH		50.7924489116
178SuccinylationSREEAISKAVEATKL
CHHHHHHHHHHHHHH		50.7923954790
184AcetylationSKAVEATKLVRKLTK
HHHHHHHHHHHHHCC		52.6224489116
191SuccinylationKLVRKLTKDDPSQQA
HHHHHHCCCCHHHCC		71.2523954790
347AcetylationDVVERCNKIPVSQRA
HHHHHHHCCCHHHCC		52.6025381059
374AcetylationGSHQDAIKKGFNLQN
CCHHHHHHHCCCCCC		48.8722865919
375AcetylationSHQDAIKKGFNLQNK
CHHHHHHHCCCCCCH		63.7225381059
401AcetylationPYLPLDPKDIGRDYE
EECCCCHHHCCCCEE		62.7424489116
401UbiquitinationPYLPLDPKDIGRDYE
EECCCCHHHCCCCEE		62.7424961812
401SuccinylationPYLPLDPKDIGRDYE
EECCCCHHHCCCCEE		62.7423954790
407PhosphorylationPKDIGRDYEAVIRVN
HHHCCCCEEEEEEEE		12.3919795423
415PhosphorylationEAVIRVNSQSGKGGA
EEEEEEECCCCCCCC		23.9022369663
417PhosphorylationVIRVNSQSGKGGAAW
EEEEECCCCCCCCEE		42.1522369663
458AcetylationDSLGRELKSDEISKL
HHHCHHCCHHHHHHH		51.6224489116
464AcetylationLKSDEISKLFKEAYN
CCHHHHHHHHHHHHC		64.7024489116
464SuccinylationLKSDEISKLFKEAYN
CCHHHHHHHHHHHHC		64.7023954790
567AcetylationRRNADNEKAYKWGVG
ECCCCCCCHHCCCCC		64.3724489116
567SuccinylationRRNADNEKAYKWGVG
ECCCCCCCHHCCCCC		64.3723954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LEU1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LEU1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LEU1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LOT5_YEASTLOT5physical
10688190
SAC3_YEASTSAC3genetic
10517330
LEU9_YEASTLEU9physical
16554755
LEU9_YEASTLEU9physical
16429126
LEU9_YEASTLEU9physical
18719252
LEU1_YEASTLEU4physical
18719252
LEU9_YEASTLEU9genetic
18408719
CSG2_YEASTCSG2genetic
21623372
TPS2_YEASTTPS2genetic
21623372
LEU9_YEASTLEU9genetic
26344121
LEU9_YEASTLEU9genetic
25841022
LEU9_YEASTLEU9physical
25841022
BAP3_YEASTBAP3genetic
27708008
VAM7_YEASTVAM7genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
POM33_YEASTPOM33genetic
27708008
PUR91_YEASTADE16genetic
27708008
BUL2_YEASTBUL2genetic
27708008
ADH1_YEASTADH1genetic
27708008
YP097_YEASTYPR097Wgenetic
27708008
FBRL_YEASTNOP1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
SMD1_YEASTSMD1genetic
27708008
YIP1_YEASTYIP1genetic
27708008
NU192_YEASTNUP192genetic
27708008
GRC3_YEASTGRC3genetic
27708008
PRP19_YEASTPRP19genetic
27708008
NSE1_YEASTNSE1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
SYA_YEASTALA1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
YD157_YEASTYDL157Cgenetic
27708008
RM01_YEASTMRPL1genetic
27708008
INO2_YEASTINO2genetic
27708008
MRX8_YEASTYDR336Wgenetic
27708008
RIM15_YEASTRIM15genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
PHB2_YEASTPHB2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
FLX1_YEASTFLX1genetic
27708008
PHO86_YEASTPHO86genetic
27708008
CYT2_YEASTCYT2genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
ELO3_YEASTELO3genetic
27708008
COX7_YEASTCOX7genetic
27708008
TDA1_YEASTTDA1genetic
27708008
HMI1_YEASTHMI1genetic
27708008
PT127_YEASTPET127genetic
27708008
MSC6_YEASTMSC6genetic
27708008
H1_YEASTHHO1genetic
27708008
ISU1_YEASTISU1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
SRO7_YEASTSRO7genetic
27708008
NAA30_YEASTMAK3genetic
27708008
NHP6A_YEASTNHP6Agenetic
27708008
SPEE_YEASTSPE3genetic
27708008
MED1_YEASTMED1genetic
27708008
OPY2_YEASTOPY2genetic
27708008
YP114_YEASTYPR114Wgenetic
27708008
PHSG_YEASTGPH1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
OPT2_YEASTOPT2genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LEU1_YEAST

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Related Literatures of Post-Translational Modification

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