LEU9_YEAST - dbPTM
LEU9_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LEU9_YEAST
UniProt AC Q12166
Protein Name 2-isopropylmalate synthase 2, mitochondrial
Gene Name LEU9
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 604
Subcellular Localization Mitochondrion .
Protein Description Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis..
Protein Sequence MVKHSFIALAEHASKLRRSIPPVKLTYKNMLRDPSVKYRAFAPPKMVKRIWPDKTIQKAPRWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYNYNNNEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLSVQNYSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATVNNIIHSGDVLLAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54AcetylationVKRIWPDKTIQKAPR
HHHHCCCCCCCCCCC		43.3724489116
106PhosphorylationEVSFPSASQTDFDFT
EEECCCCCCCCCCCH		37.6427214570
400UbiquitinationPYLPLDPKDIGRDYE
EECCCCHHHCCCCEE		62.7424961812
406PhosphorylationPKDIGRDYEAVIRVN
HHHCCCCEEEEEEEE		12.3919795423
414PhosphorylationEAVIRVNSQSGKGGA
EEEEEEECCCCCCCE		23.9020377248
416PhosphorylationVIRVNSQSGKGGAAW
EEEEECCCCCCCEEE		42.1522369663
447AcetylationDFSNTLQKNADALGR
CCCHHHHHCHHHHCH		58.1624489116
457AcetylationDALGRELKSEEITKL
HHHCHHHCHHHHHHH		51.5825381059
463AcetylationLKSEEITKLFKETYN
HCHHHHHHHHHHHHC		58.5524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LEU9_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LEU9_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LEU9_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YPK1_YEASTYPK1physical
16554755
LEU1_YEASTLEU4physical
16429126
LEU9_YEASTLEU9physical
18719252
LEU1_YEASTLEU4genetic
18408719
PEX22_YEASTPEX22genetic
20093466
CSG2_YEASTCSG2genetic
20093466
MBA1_YEASTMBA1genetic
20093466
ODPB_YEASTPDB1genetic
20093466
THRC_YEASTTHR4genetic
20093466
CRD1_YEASTCRD1genetic
20093466
PEX19_YEASTPEX19genetic
20093466
HSP78_YEASTHSP78genetic
20093466
STP1_YEASTSTP1genetic
20093466
PT122_YEASTPET122genetic
20093466
ODPA_YEASTPDA1genetic
20093466
ASK10_YEASTASK10genetic
20093466
FLX1_YEASTFLX1genetic
20093466
GZF3_YEASTGZF3genetic
20093466
YKS7_YEASTFAT3genetic
20093466
ATP10_YEASTATP10genetic
20093466
SST2_YEASTSST2genetic
20093466
SCS7_YEASTSCS7genetic
20093466
MKS1_YEASTMKS1genetic
20093466
ODP2_YEASTLAT1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
VPS27_YEASTVPS27genetic
20093466
ATP23_YEASTATP23genetic
20093466
HMI1_YEASTHMI1genetic
20093466
MSC6_YEASTMSC6genetic
20093466
HAP5_YEASTHAP5genetic
20093466
TCO89_YEASTTCO89genetic
20093466
COX10_YEASTCOX10genetic
20093466
ATG5_YEASTATG5genetic
20093466
GAL7_YEASTGAL7genetic
21623372
CHO2_YEASTCHO2genetic
21623372
AMDY_YEASTAMD2genetic
21623372
CYB2_YEASTCYB2genetic
21623372
PGM1_YEASTPGM1genetic
21623372
BAP2_YEASTBAP2genetic
21623372
OAT_YEASTCAR2genetic
21623372
ALDH2_YEASTALD2genetic
21623372
PHSG_YEASTGPH1genetic
21623372
ACON_YEASTACO1genetic
21623372
INO1_YEASTINO1genetic
21623372
CHMU_YEASTARO7genetic
21623372
DLD2_YEASTDLD2genetic
21623372
COQ2_YEASTCOQ2genetic
21623372
HMDH1_YEASTHMG1genetic
21623372
LEU1_YEASTLEU4physical
25841022
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LEU9_YEAST

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Related Literatures of Post-Translational Modification

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