ALDH2_YEAST - dbPTM
ALDH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALDH2_YEAST
UniProt AC P47771
Protein Name Aldehyde dehydrogenase [NAD(P)+] 1
Gene Name ALD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 506
Subcellular Localization Cytoplasm.
Protein Description Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Required for pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis..
Protein Sequence MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAALETLDAGKPYHSNAKGDLAQILQLTRYFAGSADKFDKGATIPLTFNKFAYTLKVPFGVVAQIVPWNYPLAMACWKLQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNIVPGYGSLVGQALASHMDIDKISFTGSTKVGGFVLEASGQSNLKDVTLECGGKSPALVFEDADLDKAIDWIAAGIFYNSGQNCTANSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIVGPVISSTQYDRIKSYIERGKREEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPQTSKLLQDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINSSNDEDVTVPFGGFKMSGIGRELGQSGVDTYLQTKAVHINLSLDN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58AcetylationSFQAANEKDVDKAVK
CCEECCHHCHHHHHH		63.9624489116
62AcetylationANEKDVDKAVKAARA
CCHHCHHHHHHHHHH		55.7324489116
478PhosphorylationPFGGFKMSGIGRELG
ECCCEEECCCCHHHC		28.0524909858
495PhosphorylationGVDTYLQTKAVHINL
CCCHHEEECEEEEEE		20.5524909858
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALDH2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALDH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALDH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YKK0_YEASTYPF1physical
16554755
ALDH2_YEASTALD2physical
18719252
ALDH3_YEASTALD3genetic
10407263
ALDH5_YEASTALD5genetic
26721212
ARO10_YEASTARO10genetic
26721212
BCA1_YEASTBAT1genetic
26721212
SHE1_YEASTSHE1genetic
27708008
VAM3_YEASTVAM3genetic
27708008
BMH1_YEASTBMH1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
PHB1_YEASTPHB1genetic
27708008
SODM_YEASTSOD2genetic
27708008
MIP6_YEASTMIP6genetic
27708008
MOG1_YEASTMOG1genetic
27708008
TRPG_YEASTTRP3genetic
27708008
BCH2_YEASTBCH2genetic
27708008
ALAM_YEASTALT1genetic
27708008
COA4_YEASTCOA4genetic
27708008
ORM2_YEASTORM2genetic
27708008
YP260_YEASTYPL260Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALDH2_YEAST

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Related Literatures of Post-Translational Modification

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