ALDH3_YEAST - dbPTM
ALDH3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALDH3_YEAST
UniProt AC P54114
Protein Name Aldehyde dehydrogenase [NAD(P)+] 2
Gene Name ALD3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 506
Subcellular Localization Cytoplasm.
Protein Description Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Involved in pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis..
Protein Sequence MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAALETLDAGKPFHSNAKQDLAQIIELTRYYAGAVDKFNMGETIPLTFNKFAYTLKVPFGVVAQIVPWNYPLAMACRKMQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNVIPGYGSVVGKALGTHMDIDKISFTGSTKVGGSVLEASGQSNLKDITLECGGKSPALVFEDADLDKAIEWVANGIFFNSGQICTANSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIVGPVISSTQYDRIKSYIERGKKEEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPETSKLLRDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINQTNQEEAKVPFGGFKMSGIGRESGDTGVDNYLQIKSVHVDLSLDK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
234PhosphorylationVVGKALGTHMDIDKI
HHHHHHCCCCCCEEE		18.1921126336
257PhosphorylationGGSVLEASGQSNLKD
CCEEEEECCCCCCCE		28.1728889911
266PhosphorylationQSNLKDITLECGGKS
CCCCCEEEEECCCCC		27.0027017623
273PhosphorylationTLECGGKSPALVFED
EEECCCCCCEEEEEC		20.7621440633
478PhosphorylationPFGGFKMSGIGRESG
CCCCEEECCCCCCCC		28.0527017623
497PhosphorylationDNYLQIKSVHVDLSL
CCCEEEEEEEEEEEC		21.0522369663
503PhosphorylationKSVHVDLSLDK----
EEEEEEEECCC----		30.0222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALDH3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALDH3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALDH3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ALDH2_YEASTALD2physical
16554755
ATPK_YEASTATP17genetic
21623372
KAD2_YEASTADK1genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
IDH2_YEASTIDH2genetic
21623372
VRP1_YEASTVRP1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
SNT1_YEASTSNT1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
YJ66_YEASTYJR096Wgenetic
27708008
RM49_YEASTMRP49genetic
27708008
MMM1_YEASTMMM1genetic
27708008
ACE2_YEASTACE2genetic
27708008
ORM2_YEASTORM2genetic
27708008
PET8_YEASTPET8genetic
27708008
HMI1_YEASTHMI1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALDH3_YEAST

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Related Literatures of Post-Translational Modification

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