KAD2_YEAST - dbPTM
KAD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KAD2_YEAST
UniProt AC P07170
Protein Name Adenylate kinase {ECO:0000255|HAMAP-Rule:MF_03168}
Gene Name ADK1 {ECO:0000255|HAMAP-Rule:MF_03168}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 222
Subcellular Localization Cytoplasm, cytosol . Mitochondrion intermembrane space . 90% cytoplasmic, 10% mitochondrial.
Protein Description Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways..
Protein Sequence MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSESIRM
------CCCCCCEEE		55.7824909858
2Acetylation------MSSSESIRM
------CCCCCCEEE		55.7822814378
3Phosphorylation-----MSSSESIRMV
-----CCCCCCEEEE		22.2424909858
3Acetylation-----MSSSESIRMV
-----CCCCCCEEEE		22.243004985
4Phosphorylation----MSSSESIRMVL
----CCCCCCEEEEE		49.1024909858
6Phosphorylation--MSSSESIRMVLIG
--CCCCCCEEEEEEC		42.6624909858
19AcetylationIGPPGAGKGTQAPNL
ECCCCCCCCCCCCCH		4.9922865919
47UbiquitinationMLRSQIAKGTQLGLE
HHHHHHHHHCHHHHH		21.1323749301
47SuccinylationMLRSQIAKGTQLGLE
HHHHHHHHHCHHHHH		21.1323954790
472-HydroxyisobutyrylationMLRSQIAKGTQLGLE
HHHHHHHHHCHHHHH		21.13-
47AcetylationMLRSQIAKGTQLGLE
HHHHHHHHHCHHHHH		21.1324489116
562-HydroxyisobutyrylationTQLGLEAKKIMDQGG
CHHHHHHHHHHHCCC		42.30-
56SuccinylationTQLGLEAKKIMDQGG
CHHHHHHHHHHHCCC		42.3023954790
75AcetylationDIMVNMIKDELTNNP
HHHHHHHHHHHHCCC		43.4325381059
102AcetylationRTIPQAEKLDQMLKE
CCCCHHHHHHHHHHH		55.2924489116
108SuccinylationEKLDQMLKEQGTPLE
HHHHHHHHHCCCCHH		20.3223954790
1082-HydroxyisobutyrylationEKLDQMLKEQGTPLE
HHHHHHHHHCCCCHH		20.32-
108AcetylationEKLDQMLKEQGTPLE
HHHHHHHHHCCCCHH		20.3224489116
112PhosphorylationQMLKEQGTPLEKAIE
HHHHHCCCCHHHHHC		19.7928889911
116AcetylationEQGTPLEKAIELKVD
HCCCCHHHHHCCCCC		57.7724489116
116UbiquitinationEQGTPLEKAIELKVD
HCCCCHHHHHCCCCC		57.7723749301
121AcetylationLEKAIELKVDDELLV
HHHHHCCCCCHHHHH		30.8924489116
121UbiquitinationLEKAIELKVDDELLV
HHHHHCCCCCHHHHH		30.8922817900
132PhosphorylationELLVARITGRLIHPA
HHHHHHHHCCEECCC		40.1824961812
140PhosphorylationGRLIHPASGRSYHKI
CCEECCCCCCCHHHC		48.0017563356
143PhosphorylationIHPASGRSYHKIFNP
ECCCCCCCHHHCCCC		41.7124961812
144PhosphorylationHPASGRSYHKIFNPP
CCCCCCCHHHCCCCC		37.9124961812
146AcetylationASGRSYHKIFNPPKE
CCCCCHHHCCCCCHH		13.3922865919
152AcetylationHKIFNPPKEDMKDDV
HHCCCCCHHHCCCCC		19.6024489116
156AcetylationNPPKEDMKDDVTGEA
CCCHHHCCCCCCHHH		20.1524489116
156SuccinylationNPPKEDMKDDVTGEA
CCCHHHCCCCCCHHH		20.1523954790
1762-HydroxyisobutyrylationDDNADALKKRLAAYH
CCCHHHHHHHHHHHH		25.49-
176AcetylationDDNADALKKRLAAYH
CCCHHHHHHHHHHHH		25.4924489116
176SuccinylationDDNADALKKRLAAYH
CCCHHHHHHHHHHHH		25.4923954790
193PhosphorylationTEPIVDFYKKTGIWA
CCCCHHHHHHHCCEE		14.3828889911
194AcetylationEPIVDFYKKTGIWAG
CCCHHHHHHHCCEEE		57.3024489116
1952-HydroxyisobutyrylationPIVDFYKKTGIWAGV
CCHHHHHHHCCEEEC		56.53-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KAD2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KAD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KAD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KCY_YEASTURA6genetic
1333436
INO1_YEASTINO1physical
18467557
SPL2_YEASTSPL2genetic
18433446
ORC3_YEASTORC3physical
20659900
KPC1_YEASTPKC1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
CDC48_YEASTCDC48genetic
27708008
RLI1_YEASTRLI1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
GRP78_YEASTKAR2genetic
27708008
DBP9_YEASTDBP9genetic
27708008
IMB1_YEASTKAP95genetic
27708008
AFG2_YEASTAFG2genetic
27708008
CH10_YEASTHSP10genetic
27708008
SGT1_YEASTSGT1genetic
27708008
DED1_YEASTDED1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
IPL1_YEASTIPL1genetic
27708008
SYH_YEASTHTS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KAD2_YEAST

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Related Literatures of Post-Translational Modification

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