SYH_YEAST - dbPTM
SYH_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYH_YEAST
UniProt AC P07263
Protein Name Histidine--tRNA ligase, mitochondrial
Gene Name HTS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 546
Subcellular Localization Isoform Cytoplasmic: Cytoplasm.
Isoform Mitochondrial: Mitochondrion.
Protein Description Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion..
Protein Sequence MLSRSLNKVVTSIKSSSIIRMSSATAAATSAPTANAANALKASKAPKKGKLQVSLKTPKGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGEDSKLIYNLEDQGGELCSLRYDLTVPFARYVAMNNIQSIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDEDVRKISSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNEKAKQGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYEVVTSASAPPENASELKKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQRINSSTTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQFDAAEKAGCHIAVILGKEEYLEGKLRVKRLGQEFADDDGELVSAADIVPIVQEKLSQIHEDGLNEVTRLIKGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MLSRSLNKVV
-----CCCHHHHHHH		20.6519823750
5Phosphorylation---MLSRSLNKVVTS
---CCCHHHHHHHHH		32.6819823750
11PhosphorylationRSLNKVVTSIKSSSI
HHHHHHHHHHHHCCE		27.9319823750
12PhosphorylationSLNKVVTSIKSSSII
HHHHHHHHHHHCCEE		19.1919823750
17PhosphorylationVTSIKSSSIIRMSSA
HHHHHHCCEEEECCC		29.1722369663
48AcetylationKASKAPKKGKLQVSL
HHCCCCCCCCEEEEE		61.2825381059
50AcetylationSKAPKKGKLQVSLKT
CCCCCCCCEEEEEEC		44.6325381059
57PhosphorylationKLQVSLKTPKGTKDW
CEEEEEECCCCCCCC		35.2121440633
62SuccinylationLKTPKGTKDWADSDM
EECCCCCCCCCCCHH		61.0023954790
62AcetylationLKTPKGTKDWADSDM
EECCCCCCCCCCCHH		61.0024489116
84AcetylationSTLSGLFKKHGGVTI
HHHHHHHHHCCCEEE		49.2324489116
93PhosphorylationHGGVTIDTPVFELRE
CCCEEECCCHHHHHH		19.9425752575
105AcetylationLREILAGKYGEDSKL
HHHHHCCCCCCCCEE		44.4622865919
111AcetylationGKYGEDSKLIYNLED
CCCCCCCEEEEEEEC		51.7524489116
137PhosphorylationLTVPFARYVAMNNIQ
EHHCHHHHHHHCCHH		6.8022890988
145PhosphorylationVAMNNIQSIKRYHIA
HHHCCHHHHHHHHHE		26.7022890988
214AcetylationKIKLNHRKILDGIFQ
EEECCCHHHHHHHHH		39.8224489116
235PhosphorylationEDVRKISSAVDKLDK
HHHHHHHHHHHHHCC		35.4721440633
242AcetylationSAVDKLDKSPWEAVK
HHHHHHCCCHHHHHH		69.7024489116
256AcetylationKKEMTEEKGQSEETA
HHHHHHHCCCCHHHH		56.8924489116
265AcetylationQSEETADKIGEYVKL
CCHHHHHHHHHHHHH		50.5824489116
271AcetylationDKIGEYVKLNGSLKE
HHHHHHHHHCCCHHH		35.0224489116
412AcetylationERIFSLIKQRINSST
HHHHHHHHHHCCCCC		38.5324489116
465AcetylationIEAEYVYKAKANPRK
CCEEEEEECCCCHHH		33.1124489116
472UbiquitinationKAKANPRKQFDAAEK
ECCCCHHHHCCHHHH		57.4823749301
507 (in isoform 2)Ubiquitination-7.50-
516PhosphorylationDDDGELVSAADIVPI
CCCCCEECHHHHHHH		30.2921440633
527UbiquitinationIVPIVQEKLSQIHED
HHHHHHHHHHHHCCC		36.0323749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYH_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYH_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYH_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
POS5_YEASTPOS5genetic
21623372
ADH3_YEASTADH3genetic
21623372
DHOM_YEASTHOM6genetic
21623372
ERG2_YEASTERG2genetic
21623372
MET10_YEASTMET10genetic
21623372
YPC1_YEASTYPC1genetic
21623372
ATP5E_YEASTATP15genetic
21623372
CYS3_YEASTCYS3genetic
21623372
LCB4_YEASTLCB4genetic
21623372
THRC_YEASTTHR4genetic
21623372
SOL3_YEASTSOL3genetic
21623372
AMPD_YEASTAMD1genetic
21623372
METC_YEASTIRC7genetic
21623372
FABG_YEASTOAR1genetic
21623372
ADH1_YEASTADH1genetic
21623372
PUR4_YEASTADE6genetic
21623372
KAD2_YEASTADK1genetic
21623372
APC11_YEASTAPC11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CTK1_YEASTCTK1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
PSB6_YEASTPRE7genetic
27708008
IPYR_YEASTIPP1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
CDC7_YEASTCDC7genetic
27708008
RPN5_YEASTRPN5genetic
27708008
MAK21_YEASTMAK21genetic
27708008
RRP1_YEASTRRP1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
GPI11_YEASTGPI11genetic
27708008
ACT_YEASTACT1genetic
27708008
RCC1_YEASTSRM1genetic
27708008
XPO1_YEASTCRM1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
ARPC5_YEASTARC15genetic
27708008
NU192_YEASTNUP192genetic
27708008
KTHY_YEASTCDC8genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
GSP1_YEASTGSP1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
ARPC2_YEASTARC35genetic
27708008
NUF2_YEASTNUF2genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
SHE1_YEASTSHE1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
PFF1_YEASTPFF1genetic
27708008
REI1_YEASTREI1genetic
27708008
CHK1_YEASTCHK1genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
OCA4_YEASTOCA4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
PMT5_YEASTPMT5genetic
27708008
PP2A2_YEASTPPH22genetic
27708008
UGA4_YEASTUGA4genetic
27708008
SOK1_YEASTSOK1genetic
27708008
OCA6_YEASTOCA6genetic
27708008
INO2_YEASTINO2genetic
27708008
NUM1_YEASTNUM1genetic
27708008
DHAS_YEASTHOM2genetic
27708008
PLP1_YEASTPLP1genetic
27708008
RMD5_YEASTRMD5genetic
27708008
SUM1_YEASTSUM1genetic
27708008
SHE9_YEASTSHE9genetic
27708008
PUF6_YEASTPUF6genetic
27708008
PSP1_YEASTPSP1genetic
27708008
GLRX2_YEASTGRX2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
GCN20_YEASTGCN20genetic
27708008
GCN1_YEASTGCN1genetic
27708008
OCA5_YEASTOCA5genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
BAS1_YEASTBAS1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
RAD10_YEASTRAD10genetic
27708008
MUB1_YEASTMUB1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
OCA2_YEASTOCA2genetic
27708008
TOP1_YEASTTOP1genetic
27708008
HST1_YEASTHST1genetic
27708008
INO4_YEASTINO4genetic
27708008
VAM3_YEASTVAM3genetic
27708008
SUCA_YEASTLSC1genetic
27708008
CAF20_YEASTCAF20genetic
27708008
MBF1_YEASTMBF1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYH_YEAST

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Related Literatures of Post-Translational Modification

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