PMT5_YEAST - dbPTM
PMT5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PMT5_YEAST
UniProt AC P52867
Protein Name Dolichyl-phosphate-mannose--protein mannosyltransferase 5 {ECO:0000305}
Gene Name PMT5 {ECO:0000303|PubMed:8923743}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 743
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins..
Protein Sequence MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVRLHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLYPHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFMFYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWLGSWDFYCNSLLLSDSHYELNAES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18UbiquitinationPIPDVTIKRGPLRSF
CCCCCEEECCCCCEE		41.7723749301
29UbiquitinationLRSFLITKPCDNLSS
CCEEEEECCCCCHHH		36.3323749301
33N-linked_GlycosylationLITKPCDNLSSLRTV
EEECCCCCHHHCCCC		48.84-
35PhosphorylationTKPCDNLSSLRTVTS
ECCCCCHHHCCCCCC		33.3127017623
36PhosphorylationKPCDNLSSLRTVTSS
CCCCCHHHCCCCCCC		25.6627017623
39PhosphorylationDNLSSLRTVTSSKEK
CCHHHCCCCCCCHHH		33.1727017623
213N-linked_GlycosylationLPNSCKANKSLLAAS
CCCCHHCCHHHHHHH		21.68-
380N-linked_GlycosylationLAEHPNENVTSFQNL
EECCCCCCCCCEECC		49.35-
386N-linked_GlycosylationENVTSFQNLTDGTII
CCCCCEECCCCCCEE		42.78-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PMT5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PMT5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PMT5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BFR1_YEASTBFR1genetic
16269340
GOSR1_YEASTGOS1genetic
16269340
PMT4_YEASTPMT4genetic
16269340
PLSC_YEASTSLC1genetic
16269340
TED1_YEASTTED1genetic
16269340
TCM62_YEASTTCM62physical
16093310
PHO88_YEASTPHO88physical
16093310
FLO9_YEASTFLO9genetic
23891562
TGL2_YEASTTGL2genetic
23891562
BPH1_YEASTBPH1genetic
23891562
CND2_YEASTBRN1genetic
27708008
SWC4_YEASTSWC4genetic
27708008
STB5_YEASTSTB5genetic
27708008
PSB6_YEASTPRE7genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
SPC97_YEASTSPC97genetic
27708008
MET30_YEASTMET30genetic
27708008
HACD_YEASTPHS1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
FNTA_YEASTRAM2genetic
27708008
MED14_YEASTRGR1genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DCP2_YEASTDCP2genetic
27708008
DBP6_YEASTDBP6genetic
27708008
TYSY_YEASTCDC21genetic
27708008
TBF1_YEASTTBF1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
YRO2_YEASTYRO2genetic
27708008
SGF29_YEASTSGF29genetic
27708008
PER1_YEASTPER1genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
RDS1_YEASTRDS1genetic
27708008
CATA_YEASTCTA1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
AP3B_YEASTAPL6genetic
27708008
SLT2_YEASTSLT2genetic
27708008
CSK21_YEASTCKA1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
MRT4_YEASTMRT4genetic
27708008
FABG_YEASTOAR1genetic
27708008
MUD2_YEASTMUD2genetic
27708008
SAC1_YEASTSAC1genetic
27708008
YL173_YEASTYLR173Wgenetic
27708008
COA4_YEASTCOA4genetic
27708008
RL26A_YEASTRPL26Agenetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
RCF1_YEASTRCF1genetic
27708008
SUR7_YEASTSUR7genetic
27708008
ARGR1_YEASTARG80genetic
27708008
ASI3_YEASTASI3genetic
27708008
VPS68_YEASTVPS68genetic
27708008
STI1_YEASTSTI1genetic
27708008
OST3_YEASTOST3genetic
27708008
IES4_YEASTIES4genetic
27708008
ISW2_YEASTISW2genetic
27708008
DGK1_YEASTDGK1genetic
27708008
SVL3_YEASTSVL3genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
COX10_YEASTCOX10genetic
27708008
RBD2_YEASTRBD2genetic
27708008
PDXH_YEASTYPR172Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PMT5_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory