RDS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RDS1_YEAST
• UniProt AC: P25611
• Protein Name: Regulator of drug sensitivity 1
• Gene Name: RDS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 832
• Subcellular Localization: Nucleus .
• Protein Description: Zinc cluster transcription factor involved in resistance to cycloheximide..
• Protein Sequence: MDSITVKKPRLRLVCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERTDLSANVAANDSDGFNSSHKLNFEQQPVLERTGLRYSLQVPEGVVNATLSIWNAEDMLVIVGLVTFLDYPFAAHSLAQHDQYIRALCASLYGMALVDFSNYANGIPCEDTSRSILGPLSFIEKAIFRRIEHSKQFRVQSAALGLLYNAFSMEEENFSTLLPSLIAEVEDVLMQKKDCEILLRCFYQNIYPFYPFMDISLFESDLTSLLLQDDNNRWKISTEVKNVRKKIETLSLLTIVMAMALMHSKLDANLLSMVKENASESARKLSLLCHKLLCLLDVFRYPNENTFTCLLYFYVSEHLDPESPDCVLSPTNLLTLHHLLNLSMTLGLQYEPSKYKRFKDPEVIRQRRILWLGVQSLLFQISLAEGDAGKSNSEYMEAYLTDFEEYIEASSEYEKSSASESNVQMNDIVWNKYKFHVILSKLMSDCTSVIQHPQLFHILGNIKRSEDFMAENFPTSSIYQPLHEKEPNAIKVGKSTVLDVMDIQKTEIFLTNIVGSMCFLNIFDVLSLHFEKKCVMHWEEYEKNYHFLTLKSFNAYLKLAGLISDYLENKFQGNILESRGYIIDKQICFMLVRIWMFQCRILLRFSYKQESQKKLASSSISTNDNEKEDEMIVILERLIKHIRNQMAHLVDLAKGKLQDSYFGAYQTVPMFRYVVYLIDVGGLVSVTNGFWDKISSDGEIPPKVQQAVRLKWGLDCNNSRRIKQKLISSQSLQSFNQVLLCQMEDAVLSSSFAIKANTAMSQNTAEEFFNISEEEALNQLLENNNFDAFWDLLGENLSDMPSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	ANVAANDSDGFNSSH CCEECCCCCCCCCCC	39.17	27214570
65	Phosphorylation	DSDGFNSSHKLNFEQ CCCCCCCCCCCCCCC	26.24	27214570
280	Phosphorylation	RKKIETLSLLTIVMA HHHHHHHHHHHHHHH	28.84	19779198
293	Phosphorylation	MAMALMHSKLDANLL HHHHHHCCHHCHHHH	22.43	19779198
301	Phosphorylation	KLDANLLSMVKENAS HHCHHHHHHHHHCCC	25.37	27017623
308	Phosphorylation	SMVKENASESARKLS HHHHHCCCHHHHHHH	43.60	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RDS1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RDS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RDS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNF6_YEAST	SNF6	genetic	20093466
YNM2_YEAST	YNL122C	genetic	20093466
SODC_YEAST	SOD1	genetic	20959818
POG1_YEAST	POG1	genetic	20959818
HOS2_YEAST	HOS2	genetic	20959818
UBC9_HUMAN	UBE2I	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.