SODC_YEAST - dbPTM
SODC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SODC_YEAST
UniProt AC P00445
Protein Name Superoxide dismutase [Cu-Zn]
Gene Name SOD1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 154
Subcellular Localization Cytoplasm . Mitochondrion intermembrane space . A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space.
Protein Description Destroys radicals which are normally produced within the cells and which are toxic to biological systems..
Protein Sequence MVQAVAVLKGDAGVSGVVKFEQASESEPTTVSYEIAGNSPNAERGFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKDSLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9UbiquitinationVQAVAVLKGDAGVSG
CEEEEEEECCCCEEC		48.4224961812
15PhosphorylationLKGDAGVSGVVKFEQ
EECCCCEECEEEEEE		25.5922369663
19SumoylationAGVSGVVKFEQASES
CCEECEEEEEECCCC		40.55-
19SumoylationAGVSGVVKFEQASES
CCEECEEEEEECCCC		40.5515166219
19AcetylationAGVSGVVKFEQASES
CCEECEEEEEECCCC		40.5524489116
24PhosphorylationVVKFEQASESEPTTV
EEEEEECCCCCCEEE		41.1522369663
26PhosphorylationKFEQASESEPTTVSY
EEEECCCCCCEEEEE		46.5122369663
29PhosphorylationQASESEPTTVSYEIA
ECCCCCCEEEEEEEC		35.4622890988
30PhosphorylationASESEPTTVSYEIAG
CCCCCCEEEEEEECC		20.4022890988
32PhosphorylationESEPTTVSYEIAGNS
CCCCEEEEEEECCCC		18.2422890988
33PhosphorylationSEPTTVSYEIAGNSP
CCCEEEEEEECCCCC		13.6622890988
39PhosphorylationSYEIAGNSPNAERGF
EEEECCCCCCCCCCE		20.7222369663
58GlutathionylationFGDATNGCVSAGPHF
CCCCCCCCCCCCCCC		2.0722833525
69AcetylationGPHFNPFKKTHGAPT
CCCCCCCCCCCCCCC		59.0024489116
69SumoylationGPHFNPFKKTHGAPT
CCCCCCCCCCCCCCC		59.00-
70SumoylationPHFNPFKKTHGAPTD
CCCCCCCCCCCCCCC		46.2415166219
70SumoylationPHFNPFKKTHGAPTD
CCCCCCCCCCCCCCC		46.24-
702-HydroxyisobutyrylationPHFNPFKKTHGAPTD
CCCCCCCCCCCCCCC		46.24-
71PhosphorylationHFNPFKKTHGAPTDE
CCCCCCCCCCCCCCC		26.5728889911
76PhosphorylationKKTHGAPTDEVRHVG
CCCCCCCCCCCEEEC		44.2323749301
89SuccinylationVGDMGNVKTDENGVA
ECCCCCEEECCCCCC		55.0123954790
89AcetylationVGDMGNVKTDENGVA
ECCCCCEEECCCCCC		55.0124489116
90PhosphorylationGDMGNVKTDENGVAK
CCCCCEEECCCCCCC		44.2428889911
97SuccinylationTDENGVAKGSFKDSL
ECCCCCCCCCHHHHH		53.3223954790
97AcetylationTDENGVAKGSFKDSL
ECCCCCCCCCHHHHH		53.3222865919
972-HydroxyisobutyrylationTDENGVAKGSFKDSL
ECCCCCCCCCHHHHH		53.32-
99PhosphorylationENGVAKGSFKDSLIK
CCCCCCCCHHHHHHH		28.5422369663
1012-HydroxyisobutyrylationGVAKGSFKDSLIKLI
CCCCCCHHHHHHHHH		48.37-
101UbiquitinationGVAKGSFKDSLIKLI
CCCCCCHHHHHHHHH		48.3723749301
101SuccinylationGVAKGSFKDSLIKLI
CCCCCCHHHHHHHHH		48.3723954790
101AcetylationGVAKGSFKDSLIKLI
CCCCCCHHHHHHHHH		48.3724489116
103PhosphorylationAKGSFKDSLIKLIGP
CCCCHHHHHHHHHCC		32.3622369663
106UbiquitinationSFKDSLIKLIGPTSV
CHHHHHHHHHCCCCE		39.0724961812
106AcetylationSFKDSLIKLIGPTSV
CHHHHHHHHHCCCCE		39.0724489116
111PhosphorylationLIKLIGPTSVVGRSV
HHHHHCCCCEECCEE		29.0128889911
112PhosphorylationIKLIGPTSVVGRSVV
HHHHCCCCEECCEEE		20.2417287358
117PhosphorylationPTSVVGRSVVIHAGQ
CCCEECCEEEEECCC		18.1422369663
129AcetylationAGQDDLGKGDTEESL
CCCCCCCCCCCHHHH		61.9924489116
1292-HydroxyisobutyrylationAGQDDLGKGDTEESL
CCCCCCCCCCCHHHH		61.99-
129UbiquitinationAGQDDLGKGDTEESL
CCCCCCCCCCCHHHH		61.9923749301
129SuccinylationAGQDDLGKGDTEESL
CCCCCCCCCCCHHHH		61.9923954790
132PhosphorylationDDLGKGDTEESLKTG
CCCCCCCCHHHHHHC		50.7717287358
135PhosphorylationGKGDTEESLKTGNAG
CCCCCHHHHHHCCCC		29.0020377248
137AcetylationGDTEESLKTGNAGPR
CCCHHHHHHCCCCCC		64.7624489116
137UbiquitinationGDTEESLKTGNAGPR
CCCHHHHHHCCCCCC		64.7623749301
138PhosphorylationDTEESLKTGNAGPRP
CCHHHHHHCCCCCCC		40.7523749301
153PhosphorylationACGVIGLTN------
CCCEEECCC------		33.4021440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SODC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SODC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SODC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCS1_YEASTCCS1physical
11101286
CCS1_YEASTCCS1physical
10944535
CCS1_YEASTCCS1physical
11524675
ATX2_YEASTATX2genetic
8887660
TKT1_YEASTTKL1genetic
8910528
SODM_YEASTSOD2genetic
10882731
FET3_YEASTFET3genetic
10766782
BSD2_YEASTBSD2genetic
8530401
ATC1_YEASTPMR1genetic
8530401
SODM_YEASTSOD2genetic
8530401
ATC1_YEASTPMR1genetic
7862131
ATC1_YEASTPMR1genetic
1526970
BSD2_YEASTBSD2genetic
9115231
BSD2_YEASTBSD2genetic
1526970
JAC1_YEASTJAC1genetic
9813017
NFS1_YEASTNFS1genetic
9813017
HSP7Q_YEASTSSQ1genetic
9813017
SODM_YEASTSOD2genetic
9722512
MMT1_YEASTMMT1genetic
15107423
CALM_YEASTCMD1physical
16554755
YD176_YEASTYDL176Wphysical
16554755
GRP78_YEASTKAR2physical
16554755
CCS1_YEASTCCS1physical
16554755
TKT1_YEASTTKL1genetic
16287844
MED20_YEASTSRB2genetic
17314980
SA155_YEASTSAP155genetic
17314980
MED3_YEASTPGD1genetic
17314980
DPOD3_YEASTPOL32genetic
17314980
RAD51_YEASTRAD51genetic
17314980
RAD54_YEASTRAD54genetic
17314980
SPT3_YEASTSPT3genetic
17314980
SWD3_YEASTSWD3genetic
17314980
MET18_YEASTMET18genetic
17314980
PCNA_YEASTPOL30genetic
17314980
PTPA1_YEASTRRD1genetic
17314980
SUS1_YEASTSUS1genetic
17314980
MUS81_YEASTMUS81genetic
17314980
PUS3_YEASTDEG1genetic
17314980
BRE1_YEASTBRE1genetic
17314980
RPN14_YEASTRPN14genetic
17314980
TFB1_YEASTTFB1genetic
17314980
RUVB1_YEASTRVB1genetic
17314980
RAD57_YEASTRAD57genetic
17314980
UBC2_YEASTRAD6genetic
17314980
SDC1_YEASTSDC1genetic
17314980
ELP2_YEASTELP2genetic
17314980
SWI4_YEASTSWI4genetic
17314980
XRN1_YEASTXRN1genetic
17314980
SWD1_YEASTSWD1genetic
17314980
PSA3_YEASTPRE9genetic
17314980
CTF8_YEASTCTF8genetic
17314980
BUB1_YEASTBUB1genetic
17314980
SWR1_YEASTSWR1genetic
17314980
SSD1_YEASTSSD1genetic
17314980
ARD1_YEASTARD1genetic
17314980
PAF1_YEASTPAF1genetic
17314980
ACT_YEASTACT1genetic
17314980
ATC1_YEASTPMR1genetic
8887660
BSD2_YEASTBSD2genetic
8887660
SODC_YEASTSOD1physical
1772629
TFS2_YEASTDST1genetic
19547744
SAN1_YEASTSAN1genetic
19547744
RT103_YEASTRTT103genetic
19547744
BYE1_YEASTBYE1genetic
19547744
HAA1_YEASTHAA1genetic
19547744
BDF1_YEASTBDF1genetic
19547744
ECM5_YEASTECM5genetic
19547744
SUB1_YEASTSUB1genetic
19547744
MAD1_YEASTMAD1genetic
19547744
BDF2_YEASTBDF2genetic
19547744
PFD6_YEASTYKE2genetic
19547744
H4_YEASTHHF1genetic
19547744
H3_YEASTHHT1genetic
19547744
ATC1_YEASTPMR1genetic
18977757
BSD2_YEASTBSD2genetic
18973803
ATC1_YEASTPMR1genetic
18973803
SMF1_YEASTSMF1genetic
18973803
VTC4_YEASTVTC4genetic
18973803
PHO80_YEASTPHO80genetic
18973803
TKT1_YEASTTKL1genetic
19129474
GPT_YEASTALG7genetic
19129474
HAC1_YEASTHAC1genetic
19129474
COQ1_YEASTCOQ1genetic
15641941
SML1_YEASTSML1genetic
19851444
RFX1_YEASTRFX1genetic
19851444
DUN1_YEASTDUN1genetic
19851444
SODM_YEASTSOD2genetic
19756144
SODM_YEASTSOD2genetic
20131044
CHS3_YEASTCHS3genetic
20176017
SODM_YEASTSOD2genetic
20202201
ATC1_YEASTPMR1genetic
17603109
ISU1_YEASTISU1genetic
15107423
NFS1_YEASTNFS1genetic
15107423
JAC1_YEASTJAC1genetic
15107423
HSP7Q_YEASTSSQ1genetic
15107423
MKS1_YEASTMKS1genetic
15107423
ATC1_YEASTPMR1genetic
20702768
PHO85_YEASTPHO85genetic
20702768
SMF2_YEASTSMF2genetic
20702768
SMT3_YEASTSMT3physical
20828586
MSN4_YEASTMSN4genetic
20959818
SNT1_YEASTSNT1genetic
20959818
STB2_YEASTSTB2genetic
20959818
SGF73_YEASTSGF73genetic
20959818
IME4_YEASTIME4genetic
20959818
UME1_YEASTUME1genetic
20959818
DOA1_YEASTDOA1genetic
20959818
BAS1_YEASTBAS1genetic
20959818
HOS2_YEASTHOS2genetic
20959818
ECM5_YEASTECM5genetic
20959818
SUB1_YEASTSUB1genetic
20959818
THI2_YEASTTHI2genetic
20959818
SUT1_YEASTSUT1genetic
20959818
GCR2_YEASTGCR2genetic
20959818
PHO84_YEASTPHO84genetic
21926297
PHO80_YEASTPHO80genetic
21926297
RIM15_YEASTRIM15genetic
21926297
SCH9_YEASTSCH9genetic
21926297
GIS1_YEASTGIS1genetic
21926297
MSN2_YEASTMSN2genetic
21926297
MSN4_YEASTMSN4genetic
21926297
YCFI_YEASTYCF1genetic
22449970
GPR1_YEASTGPR1genetic
23332757
GPA2_YEASTGPA2genetic
23332757
RAS2_YEASTRAS2genetic
23332757
HXKB_YEASTHXK2genetic
23332757
SODM_YEASTSOD2genetic
24028688
CCS1_YEASTCCS1genetic
24444374
PMA1_YEASTPMA1genetic
25956063
CATT_YEASTCTT1genetic
25573485
BSD2_YEASTBSD2genetic
28454894
HEM2_YEASTHEM2genetic
28454894
CCS1_YEASTCCS1physical
28533431
SODM_YEASTSOD2genetic
26518674
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SODC_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-24; SER-26;SER-39; SER-99 AND SER-103, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39 AND SER-99, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-112; SER-117 ANDTHR-132, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASSSPECTROMETRY.
Sumoylation
ReferencePubMed
"Global analyses of sumoylated proteins in Saccharomyces cerevisiae.Induction of protein sumoylation by cellular stresses.";
Zhou W., Ryan J.J., Zhou H.;
J. Biol. Chem. 279:32262-32268(2004).
Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-19 AND LYS-70, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory