JAC1_YEAST - dbPTM
JAC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JAC1_YEAST
UniProt AC P53193
Protein Name J-type co-chaperone JAC1, mitochondrial
Gene Name JAC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 184
Subcellular Localization Mitochondrion matrix .
Protein Description Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1. Binds to the substrate protein ISU1 and targets it to SSQ1. May function together with SSQ1 in the dislocation of the Fe/S cluster from ISU1 and its insertion into apoproteins..
Protein Sequence MLKYLVQRRFTSTFYELFPKTFPKKLPIWTIDQSRLRKEYRQLQAQHHPDMAQQGSEQSSTLNQAYHTLKDPLRRSQYMLKLLRNIDLTQEQTSNEVTTSDPQLLLKVLDIHDELSQMDDEAGVKLLEKQNKERIQDIEAQLGQCYNDKDYAAAVKLTVELKYWYNLAKAFKDWAPGKQLEMNH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
70AcetylationNQAYHTLKDPLRRSQ
HHHHHHHHCHHHHHH		59.4624489116
169AcetylationKYWYNLAKAFKDWAP
HHHHHHHHHHHHCCC		58.4824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JAC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JAC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JAC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP7Q_YEASTSSQ1genetic
11278728
ISU1_YEASTISU1physical
16551614
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
PP2C4_YEASTPTC4genetic
20093466
BRE4_YEASTBRE4genetic
20093466
WDR59_YEASTMTC5genetic
20093466
LIC4_YEASTATC1genetic
20093466
PEX5_YEASTPEX5genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
EMI1_YEASTEMI1genetic
20093466
MMS2_YEASTMMS2genetic
20093466
MPC1_YEASTMPC1genetic
20093466
PTH_YEASTPTH1genetic
20093466
YRA2_YEASTYRA2genetic
20093466
PPR1_YEASTPPR1genetic
20093466
YPT6_YEASTYPT6genetic
20093466
AEP2_YEASTAEP2genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
MED9_YEASTCSE2genetic
20093466
INO4_YEASTINO4genetic
20093466
CY1_YEASTCYT1genetic
20093466
VAM3_YEASTVAM3genetic
20093466
HSP7F_YEASTSSE1genetic
20093466
QCR2_YEASTQCR2genetic
20093466
NFS1_YEASTNFS1genetic
18843040
ISU1_YEASTISU1physical
24573684
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JAC1_YEAST

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Related Literatures of Post-Translational Modification

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