WDR59_YEAST - dbPTM
WDR59_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR59_YEAST
UniProt AC Q03897
Protein Name Maintenance of telomere capping protein 5
Gene Name MTC5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1148
Subcellular Localization Vacuole membrane
Peripheral membrane protein .
Protein Description Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in telomere capping..
Protein Sequence MCSSINEGPYNSPTFGKSLSLKVDGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPRWLHHITPWQVADVQWSPHPAKPYWIVSTSNQKAIIWNLAKSSSNAIEFVLHGHSRAITDINFNPQHPDVLATCSVDTYVHAWDMRSPHRPFYSTSSWRSAASQVKWNYKDPNVLASSHGNDIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYSEIMSSSNDGTVKFWDYSKSTTESKRTVTTNFPIWRGRYLPFGEGYCIMPMVGGNNAVYLINLCDDDDSEQNKKTKLQPIYAFKGHSDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISDSIYGKVNFDRGKRLEEKLPDYDYCSYNKEPENRENVQKNEFRRLRENFVTTSGLKKNKTNHITWLSGIRMNSATSQEDLFNETKIQNLGEEVSAIGHKFPKVVFEKISVSTRELCLTLNGPWSEENPDDYIFLRISINFPLNYPNKGDPPKFTIEENSNLTMSKRQEILSNLATIGQKYTDSNLYCLEPCIRFVLGEKVSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYSDSQNPENLSSQSDIESYKEALVFPDTSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANEKKPEKKQNAIIKLSQKEAGVEKHPFKIEPQVLYDKEVDSSVITAADELKARPKRYVDTLGLGGGTNGDSRTYFDDETSSDDSFDSVADDWDDILRNDIIVRTKIPILRGNFKAFSSVHSESGKTVESTKKNKNLVISKNFSSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDLDEISHCWQILSDMLIDQSDYDPYTTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSARRKKIPARYYGQELENMEGTIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGGDNSSIRSDDHHARLRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMPDIKVELLHDDIIEAYEQEDLLHLEVSDIPKFQTYIYQYSKLLFRWGLPLERVKILKVSTDFRSSYSSQGIPPNNNKKSPYNGVLTHWIENNEFGEEKFLARNCNYCDLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGCNCPEMFDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
88PhosphorylationKPYWIVSTSNQKAII
CCEEEEECCCCEEEE		22.3219779198
401PhosphorylationSGLKKNKTNHITWLS
CCCCCCCCCCEEEEE		41.2324961812
405PhosphorylationKNKTNHITWLSGIRM
CCCCCCEEEEECCCC		16.8924961812
408PhosphorylationTNHITWLSGIRMNSA
CCCEEEEECCCCCCC		24.6024961812
414PhosphorylationLSGIRMNSATSQEDL
EECCCCCCCCCHHHH		24.4729136822
416PhosphorylationGIRMNSATSQEDLFN
CCCCCCCCCHHHHCC		30.6622369663
417PhosphorylationIRMNSATSQEDLFNE
CCCCCCCCHHHHCCH		31.1522369663
425PhosphorylationQEDLFNETKIQNLGE
HHHHCCHHHHHHHHH		34.2524961812
435PhosphorylationQNLGEEVSAIGHKFP
HHHHHHHHHHCCCCC		19.9028889911
440AcetylationEVSAIGHKFPKVVFE
HHHHHCCCCCHHHEE		59.1424489116
512PhosphorylationSKRQEILSNLATIGQ
HHHHHHHHHHHHHCC		35.1429688323
516PhosphorylationEILSNLATIGQKYTD
HHHHHHHHHCCCCCC		28.8929688323
656UbiquitinationAIIKLSQKEAGVEKH
CEEEHHHHHHCCCCC		46.2723749301
675UbiquitinationEPQVLYDKEVDSSVI
CCEEECCCCCCCHHE		46.1923749301
679PhosphorylationLYDKEVDSSVITAAD
ECCCCCCCHHEHHHH		31.5124961812
680PhosphorylationYDKEVDSSVITAADE
CCCCCCCHHEHHHHH		17.0527214570
683PhosphorylationEVDSSVITAADELKA
CCCCHHEHHHHHHHC		17.4021551504
695PhosphorylationLKARPKRYVDTLGLG
HHCCCCEECCCCCCC		14.5925005228
705PhosphorylationTLGLGGGTNGDSRTY
CCCCCCCCCCCCCCC		39.0225005228
709PhosphorylationGGGTNGDSRTYFDDE
CCCCCCCCCCCCCCC		28.1127214570
755PhosphorylationRGNFKAFSSVHSESG
CCCEEECEEEECCCC		35.9922369663
756PhosphorylationGNFKAFSSVHSESGK
CCEEECEEEECCCCC		19.8622369663
759PhosphorylationKAFSSVHSESGKTVE
EECEEEECCCCCCEE		31.1622369663
761PhosphorylationFSSVHSESGKTVEST
CEEEECCCCCCEEEC		48.9122369663
764PhosphorylationVHSESGKTVESTKKN
EECCCCCCEEECCCC		32.7921551504
767PhosphorylationESGKTVESTKKNKNL
CCCCCEEECCCCCCE		40.9928889911
777PhosphorylationKNKNLVISKNFSSLL
CCCCEEECCCHHHHH		17.6728889911
781PhosphorylationLVISKNFSSLLSDRK
EEECCCHHHHHCCCH		29.4828889911
785PhosphorylationKNFSSLLSDRKELAL
CCHHHHHCCCHHHHH		40.4328889911
918PhosphorylationNTSFWKGSDAFSTRS
CCEEEECCCCCCCCC		23.2624961812
922PhosphorylationWKGSDAFSTRSRSST
EECCCCCCCCCCCCC		25.3225704821
923PhosphorylationKGSDAFSTRSRSSTV
ECCCCCCCCCCCCCC		26.6424961812
925PhosphorylationSDAFSTRSRSSTVTP
CCCCCCCCCCCCCCC		36.2822369663
927PhosphorylationAFSTRSRSSTVTPNF
CCCCCCCCCCCCCCC		31.4422369663
928PhosphorylationFSTRSRSSTVTPNFY
CCCCCCCCCCCCCCC		26.2822369663
929PhosphorylationSTRSRSSTVTPNFYG
CCCCCCCCCCCCCCC		29.6422369663
931PhosphorylationRSRSSTVTPNFYGNH
CCCCCCCCCCCCCCC		16.7722369663
950PhosphorylationNIHGGDNSSIRSDDH
CCCCCCCCCCCCCCC		31.7017563356
951PhosphorylationIHGGDNSSIRSDDHH
CCCCCCCCCCCCCCH		28.4225005228
954PhosphorylationGDNSSIRSDDHHARL
CCCCCCCCCCCHHHH		45.8025005228
986PhosphorylationKQGSRAISSSPFHSR
HCCCCCCCCCCCHHC		24.6322369663
987PhosphorylationQGSRAISSSPFHSRM
CCCCCCCCCCCHHCC		35.6022369663
988PhosphorylationGSRAISSSPFHSRMP
CCCCCCCCCCHHCCC		25.4622369663
992PhosphorylationISSSPFHSRMPDIKV
CCCCCCHHCCCCCEE		30.5622369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR59_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR59_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR59_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPZ_YEASTCCT6physical
11805837
FMP10_YEASTFMP10physical
11805837
ACOX_YEASTPOX1physical
11805837
MDJ1_YEASTMDJ1physical
11805837
PPID_YEASTCPR6physical
11805837
SEH1_YEASTSEH1physical
11805837
IF4E_YEASTCDC33physical
11805837
NPR2_YEASTNPR2physical
11805837
YHJ3_YEASTYHR033Wphysical
11805837
THI21_YEASTTHI21physical
11805837
RNQ1_YEASTRNQ1physical
11805837
SEC13_YEASTSEC13physical
10688190
HSP73_YEASTSSA3physical
16554755
YO093_YEASTYOR093Cphysical
16554755
MGA2_YEASTMGA2genetic
19325107
ELO3_YEASTELO3genetic
19325107
ILM1_YEASTILM1genetic
19325107
IML1_YEASTIML1physical
21454883
NPR3_YEASTNPR3physical
21454883
RTC1_YEASTRTC1physical
21454883
SEA4_YEASTSEA4physical
21454883
NPR2_YEASTNPR2physical
21454883
SEH1_YEASTSEH1physical
21454883
SEC13_YEASTSEC13physical
21454883
SEA4_YEASTSEA4genetic
21454883
IML1_YEASTIML1genetic
25943524
TRPF_YEASTTRP1genetic
25943524
KPC1_YEASTPKC1genetic
27708008
ESP1_YEASTESP1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
MYO2_YEASTMYO2genetic
27708008
SEC62_YEASTSEC62genetic
27708008
ECM8_YEASTECM8genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
GTR2_YEASTGTR2genetic
27708008
NPR3_YEASTNPR3genetic
27708008
MEH1_YEASTMEH1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
RRP42_YEASTRRP42genetic
27708008
CDC53_YEASTCDC53genetic
27708008
SEC20_YEASTSEC20genetic
27708008
PMM_YEASTSEC53genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRS8_YEASTRPT6genetic
27708008
TAF6_YEASTTAF6genetic
27708008
ATC7_YEASTNEO1genetic
27708008
NU192_YEASTNUP192genetic
27708008
KTHY_YEASTCDC8genetic
27708008
SEC22_YEASTSEC22genetic
27708008
NSE5_YEASTNSE5genetic
27708008
SEC65_YEASTSEC65genetic
27708008
LCB1_YEASTLCB1genetic
27708008
LST8_YEASTLST8genetic
27708008
DCP2_YEASTDCP2genetic
27708008
TPT1_YEASTTPT1genetic
27708008
OST2_YEASTOST2genetic
27708008
MED4_YEASTMED4genetic
27708008
DED1_YEASTDED1genetic
27708008
APC5_YEASTAPC5genetic
27708008
NAB3_YEASTNAB3genetic
27708008
CET1_YEASTCET1genetic
27708008
SWD1_YEASTSWD1genetic
27708008
SEA4_YEASTSEA4genetic
27708008
MIX23_YEASTMIX23genetic
27708008
CLPX_YEASTMCX1genetic
27708008
STE50_YEASTSTE50genetic
27708008
BUD31_YEASTBUD31genetic
27708008
BRE1_YEASTBRE1genetic
27708008
IPK1_YEASTIPK1genetic
27708008
AK_YEASTHOM3genetic
27708008
RAD4_YEASTRAD4genetic
27708008
PIB2_YEASTPIB2genetic
27708008
TFS2_YEASTDST1genetic
27708008
MPC1_YEASTMPC1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
PSA3_YEASTPRE9genetic
27708008
ELP2_YEASTELP2genetic
27708008
SERB_YEASTSER2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
STB5_YEASTSTB5genetic
27708008
BCK1_YEASTBCK1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
LST4_YEASTLST4genetic
27708008
UBR2_YEASTUBR2genetic
27708008
ERG3_YEASTERG3genetic
27708008
AVL9_YEASTAVL9genetic
27708008
GBLP_YEASTASC1genetic
27708008
ERG2_YEASTERG2genetic
27708008
ROY1_YEASTROY1genetic
27708008
FAR11_YEASTFAR11genetic
27708008
PFD4_YEASTGIM3genetic
27708008
INO4_YEASTINO4genetic
27708008
WHI2_YEASTWHI2genetic
27708008
LEO1_YEASTLEO1genetic
27708008
IDH2_YEASTIDH2genetic
27708008
SERC_YEASTSER1genetic
27708008
ELP3_YEASTELP3genetic
27708008
ELP4_YEASTELP4genetic
27708008
CHMU_YEASTARO7genetic
27708008
MED1_YEASTMED1genetic
27708008
TKT1_YEASTTKL1genetic
27708008
IML1_YEASTIML1physical
25073740
RTC1_YEASTRTC1physical
25073740
NPR3_YEASTNPR3physical
25073740
SEA4_YEASTSEA4physical
25073740
NPR2_YEASTNPR2physical
25073740
SEH1_YEASTSEH1physical
25073740
SEC13_YEASTSEC13physical
25073740
IML1_YEASTIML1genetic
23716719
NPR2_YEASTNPR2genetic
23716719
NPR3_YEASTNPR3genetic
23716719
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR59_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-416; SER-417; SER-759;SER-922 AND SER-988, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759 AND SER-950, ANDMASS SPECTROMETRY.

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