| UniProt ID | DCP2_YEAST | |
|---|---|---|
| UniProt AC | P53550 | |
| Protein Name | m7GpppN-mRNA hydrolase {ECO:0000305} | |
| Gene Name | DCP2 {ECO:0000303|PubMed:10508173} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 970 | |
| Subcellular Localization | Cytoplasm, P-body . | |
| Protein Description | Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. [PubMed: 10508173] | |
| Protein Sequence | MSLPLRHALENVTSVDRILEDLLVRFIINCPNEDLSSVERELFHFEEASWFYTDFIKLMNPTLPSLKIKSFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKSIPVRGAAIFNENLSKILLVQGTESDSWSFPRGKISKDENDIDCCIREVKEEIGFDLTDYIDDNQFIERNIQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYKSNIKYYLINSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQIDPGRELLNMLHTAVQANSNNNAVSNGQVPSSQELQHLKEQSGEHNQQKDQQSSFSSQQQPSIFPSLSEPFANNKNVIPPTMPMANVFMSNPQLFATMNGQPFAPFPFMLPLTNNSNSANPIPTPVPPNFNAPPNPMAFGVPNMHNLSGPAVSQPFSLPPAPLPRDSGYSSSSPGQLLDILNSKKPDSNVQSSKKPKLKILQRGTDLNSIKQNNNDETAHSNSQALLDLLKKPTSSQKIHASKPDTSFLPNDSVSGIQDAEYEDFESSSDEEVETARDERNSLNVDIGVNVMPSEKDSRRSQKEKPRNDASKTNLNASAESNSVEWGPGKSSPSTQSKQNSSVGMQNKYRQEIHIGDSDAYEVFESSSDEEDGKKLEELEQTQDNSKLISQDILKENNFQDGEVPHRDMPTESNKSINETVGLSSTTNTVKKVPKVKILKRGETFASLANDKKAFDSSSNVSSSKDLLQMLRNPISSTVSSNQQSPKSQHLSGDEEIMMMLKRNSVSKPQNSEENASTSSINDANASELLGMLKQKEKDITAPKQPYNVDSYSQKNSAKGLLNILKKNDSTGYPRTEGGPSSEMSTSMKRNDATNNQELDKNSTELLNYLKPKPLNDGYENISNKDSSHELLNILHGNKNSSAFNNNVYATDGYSLASDNNENSSNKLLNMLQNRSSAINEPNFDVRSNGTSGSNELLSILHRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 53 | Phosphorylation | EEASWFYTDFIKLMN HHHHHHHHHHHHHHC | 18.24 | 19779198 | |
| 65 | Phosphorylation | LMNPTLPSLKIKSFA HHCCCCCCCCHHHHH | 45.46 | 19779198 | |
| 69 | Acetylation | TLPSLKIKSFAQLII CCCCCCHHHHHHHHH | 37.62 | 24489116 | |
| 98 | Acetylation | EALQQFSKYKKSIPV HHHHHHHHHCCCCCC | 63.48 | 24489116 | |
| 116 | Phosphorylation | AIFNENLSKILLVQG HHHCCCCCCEEEEEC | 29.27 | 27214570 | |
| 137 | Phosphorylation | SFPRGKISKDENDID CCCCCCCCCCCCCHH | 37.22 | 28889911 | |
| 208 | Acetylation | KIEWFDFKKISKTMY EECEECHHHHCCHHH | 51.55 | 24489116 | |
| 319 | Phosphorylation | NQQKDQQSSFSSQQQ HHHHHHHHCCCCCCC | 27.93 | 21440633 | |
| 320 | Phosphorylation | QQKDQQSSFSSQQQP HHHHHHHCCCCCCCC | 25.47 | 28889911 | |
| 322 | Phosphorylation | KDQQSSFSSQQQPSI HHHHHCCCCCCCCCC | 29.23 | 30377154 | |
| 323 | Phosphorylation | DQQSSFSSQQQPSIF HHHHCCCCCCCCCCC | 29.96 | 21440633 | |
| 433 | Phosphorylation | PAPLPRDSGYSSSSP CCCCCCCCCCCCCCH | 40.69 | 22369663 | |
| 435 | Phosphorylation | PLPRDSGYSSSSPGQ CCCCCCCCCCCCHHH | 14.88 | 22369663 | |
| 436 | Phosphorylation | LPRDSGYSSSSPGQL CCCCCCCCCCCHHHH | 27.54 | 22369663 | |
| 437 | Phosphorylation | PRDSGYSSSSPGQLL CCCCCCCCCCHHHHH | 26.76 | 22369663 | |
| 438 | Phosphorylation | RDSGYSSSSPGQLLD CCCCCCCCCHHHHHH | 34.31 | 22369663 | |
| 439 | Phosphorylation | DSGYSSSSPGQLLDI CCCCCCCCHHHHHHH | 34.69 | 22369663 | |
| 454 | Phosphorylation | LNSKKPDSNVQSSKK HHCCCCCCCCCCCCC | 47.64 | 28889911 | |
| 471 | Phosphorylation | LKILQRGTDLNSIKQ HHEECCCCCHHHHHH | 39.23 | 20377248 | |
| 475 | Phosphorylation | QRGTDLNSIKQNNND CCCCCHHHHHHCCCC | 38.16 | 21551504 | |
| 484 | Phosphorylation | KQNNNDETAHSNSQA HHCCCCHHCHHHHHH | 32.31 | 22369663 | |
| 487 | Phosphorylation | NNDETAHSNSQALLD CCCHHCHHHHHHHHH | 35.39 | 22369663 | |
| 489 | Phosphorylation | DETAHSNSQALLDLL CHHCHHHHHHHHHHH | 21.61 | 22369663 | |
| 528 | Phosphorylation | SGIQDAEYEDFESSS CCCCCHHHCCCCCCC | 23.63 | 19779198 | |
| 534 | Phosphorylation | EYEDFESSSDEEVET HHCCCCCCCHHHHHH | 34.31 | 19779198 | |
| 535 | Phosphorylation | YEDFESSSDEEVETA HCCCCCCCHHHHHHH | 59.32 | 19779198 | |
| 548 | Phosphorylation | TARDERNSLNVDIGV HHHHHHHHCCEEEEE | 27.78 | 25371407 | |
| 564 | Phosphorylation | VMPSEKDSRRSQKEK ECCCHHHCCHHHCCC | 40.43 | 29136822 | |
| 577 | Phosphorylation | EKPRNDASKTNLNAS CCCCCHHHHCCCCCC | 42.76 | 25752575 | |
| 579 | Phosphorylation | PRNDASKTNLNASAE CCCHHHHCCCCCCCC | 42.30 | 22369663 | |
| 584 | Phosphorylation | SKTNLNASAESNSVE HHCCCCCCCCCCCCC | 31.34 | 22369663 | |
| 587 | Phosphorylation | NLNASAESNSVEWGP CCCCCCCCCCCCCCC | 33.84 | 22369663 | |
| 589 | Phosphorylation | NASAESNSVEWGPGK CCCCCCCCCCCCCCC | 30.60 | 22369663 | |
| 596 | Ubiquitination | SVEWGPGKSSPSTQS CCCCCCCCCCCCCCC | 51.39 | 23749301 | |
| 597 | Phosphorylation | VEWGPGKSSPSTQSK CCCCCCCCCCCCCCC | 54.09 | 20377248 | |
| 598 | Phosphorylation | EWGPGKSSPSTQSKQ CCCCCCCCCCCCCCC | 26.76 | 22369663 | |
| 600 | Phosphorylation | GPGKSSPSTQSKQNS CCCCCCCCCCCCCCC | 40.81 | 20377248 | |
| 601 | Phosphorylation | PGKSSPSTQSKQNSS CCCCCCCCCCCCCCC | 40.00 | 22369663 | |
| 603 | Phosphorylation | KSSPSTQSKQNSSVG CCCCCCCCCCCCCCC | 35.98 | 22369663 | |
| 604 | Ubiquitination | SSPSTQSKQNSSVGM CCCCCCCCCCCCCCC | 43.62 | 23749301 | |
| 607 | Phosphorylation | STQSKQNSSVGMQNK CCCCCCCCCCCCCHH | 24.73 | 24909858 | |
| 608 | Phosphorylation | TQSKQNSSVGMQNKY CCCCCCCCCCCCHHH | 30.18 | 22369663 | |
| 611 | Oxidation | KQNSSVGMQNKYRQE CCCCCCCCCHHHCCE | 3.58 | 15665377 | |
| 614 | Acetylation | SSVGMQNKYRQEIHI CCCCCCHHHCCEEEE | 25.56 | 25381059 | |
| 614 | Ubiquitination | SSVGMQNKYRQEIHI CCCCCCHHHCCEEEE | 25.56 | 23749301 | |
| 627 | Phosphorylation | HIGDSDAYEVFESSS EECCCCHHHHHHCCC | 20.02 | 19795423 | |
| 632 | Phosphorylation | DAYEVFESSSDEEDG CHHHHHHCCCCCCCC | 24.55 | 19795423 | |
| 633 | Phosphorylation | AYEVFESSSDEEDGK HHHHHHCCCCCCCCH | 34.31 | 19795423 | |
| 634 | Phosphorylation | YEVFESSSDEEDGKK HHHHHCCCCCCCCHH | 59.32 | 19795423 | |
| 648 | Phosphorylation | KLEELEQTQDNSKLI HHHHHHHHHCCHHHC | 28.63 | 21551504 | |
| 652 | Phosphorylation | LEQTQDNSKLISQDI HHHHHCCHHHCCHHH | 36.81 | 25521595 | |
| 656 | Phosphorylation | QDNSKLISQDILKEN HCCHHHCCHHHHHHC | 32.03 | 21440633 | |
| 661 | Acetylation | LISQDILKENNFQDG HCCHHHHHHCCCCCC | 59.74 | 24489116 | |
| 677 | Phosphorylation | VPHRDMPTESNKSIN CCCCCCCCCCCCCHH | 45.46 | 22369663 | |
| 679 | Phosphorylation | HRDMPTESNKSINET CCCCCCCCCCCHHHC | 52.62 | 22369663 | |
| 682 | Phosphorylation | MPTESNKSINETVGL CCCCCCCCHHHCCCC | 34.59 | 22369663 | |
| 686 | Phosphorylation | SNKSINETVGLSSTT CCCCHHHCCCCCCCC | 18.52 | 22369663 | |
| 690 | Phosphorylation | INETVGLSSTTNTVK HHHCCCCCCCCCCCC | 21.51 | 22369663 | |
| 691 | Phosphorylation | NETVGLSSTTNTVKK HHCCCCCCCCCCCCC | 44.27 | 22369663 | |
| 692 | Phosphorylation | ETVGLSSTTNTVKKV HCCCCCCCCCCCCCC | 22.23 | 22369663 | |
| 693 | Phosphorylation | TVGLSSTTNTVKKVP CCCCCCCCCCCCCCC | 30.73 | 22369663 | |
| 695 | Phosphorylation | GLSSTTNTVKKVPKV CCCCCCCCCCCCCCE | 31.45 | 22369663 | |
| 710 | Phosphorylation | KILKRGETFASLAND EEEECCCCHHHHHCC | 27.59 | 25521595 | |
| 713 | Phosphorylation | KRGETFASLANDKKA ECCCCHHHHHCCHHH | 24.67 | 22369663 | |
| 723 | Phosphorylation | NDKKAFDSSSNVSSS CCHHHHCCCCCCCCH | 29.25 | 22369663 | |
| 724 | Phosphorylation | DKKAFDSSSNVSSSK CHHHHCCCCCCCCHH | 27.98 | 22369663 | |
| 725 | Phosphorylation | KKAFDSSSNVSSSKD HHHHCCCCCCCCHHH | 45.24 | 22369663 | |
| 728 | Phosphorylation | FDSSSNVSSSKDLLQ HCCCCCCCCHHHHHH | 32.90 | 22369663 | |
| 729 | Phosphorylation | DSSSNVSSSKDLLQM CCCCCCCCHHHHHHH | 36.80 | 22369663 | |
| 730 | Phosphorylation | SSSNVSSSKDLLQML CCCCCCCHHHHHHHH | 23.76 | 22369663 | |
| 742 | Phosphorylation | QMLRNPISSTVSSNQ HHHHCHHHHHHCCCC | 22.63 | 22890988 | |
| 743 | Phosphorylation | MLRNPISSTVSSNQQ HHHCHHHHHHCCCCC | 33.28 | 22890988 | |
| 744 | Phosphorylation | LRNPISSTVSSNQQS HHCHHHHHHCCCCCC | 20.02 | 22890988 | |
| 746 | Phosphorylation | NPISSTVSSNQQSPK CHHHHHHCCCCCCCC | 24.53 | 22890988 | |
| 747 | Phosphorylation | PISSTVSSNQQSPKS HHHHHHCCCCCCCCH | 34.03 | 22369663 | |
| 751 | Phosphorylation | TVSSNQQSPKSQHLS HHCCCCCCCCHHCCC | 25.24 | 22369663 | |
| 754 | Phosphorylation | SNQQSPKSQHLSGDE CCCCCCCHHCCCCCH | 26.64 | 22369663 | |
| 758 | Phosphorylation | SPKSQHLSGDEEIMM CCCHHCCCCCHHHHH | 41.91 | 22369663 | |
| 771 | Phosphorylation | MMMLKRNSVSKPQNS HHHHHHCCCCCCCCC | 31.62 | 22369663 | |
| 773 | Phosphorylation | MLKRNSVSKPQNSEE HHHHCCCCCCCCCCC | 38.14 | 20377248 | |
| 778 | Phosphorylation | SVSKPQNSEENASTS CCCCCCCCCCCCCCC | 40.83 | 22369663 | |
| 783 | Phosphorylation | QNSEENASTSSINDA CCCCCCCCCCCCCHH | 40.16 | 20377248 | |
| 784 | Phosphorylation | NSEENASTSSINDAN CCCCCCCCCCCCHHC | 24.88 | 22369663 | |
| 785 | Phosphorylation | SEENASTSSINDANA CCCCCCCCCCCHHCH | 27.07 | 20377248 | |
| 786 | Phosphorylation | EENASTSSINDANAS CCCCCCCCCCHHCHH | 26.04 | 22369663 | |
| 793 | Phosphorylation | SINDANASELLGMLK CCCHHCHHHHHHHHH | 28.69 | 22369663 | |
| 817 | Phosphorylation | KQPYNVDSYSQKNSA CCCCCCCCCCHHCCH | 23.54 | 22369663 | |
| 819 | Phosphorylation | PYNVDSYSQKNSAKG CCCCCCCCHHCCHHH | 38.33 | 22369663 | |
| 832 | Acetylation | KGLLNILKKNDSTGY HHHHHHHHHCCCCCC | 45.81 | 24489116 | |
| 836 | Phosphorylation | NILKKNDSTGYPRTE HHHHHCCCCCCCCCC | 32.88 | 23749301 | |
| 837 | Phosphorylation | ILKKNDSTGYPRTEG HHHHCCCCCCCCCCC | 43.53 | 28889911 | |
| 839 | Phosphorylation | KKNDSTGYPRTEGGP HHCCCCCCCCCCCCC | 6.93 | 28889911 | |
| 842 | Phosphorylation | DSTGYPRTEGGPSSE CCCCCCCCCCCCCHH | 34.18 | 22369663 | |
| 847 | Phosphorylation | PRTEGGPSSEMSTSM CCCCCCCCHHHCHHC | 42.05 | 22369663 | |
| 848 | Phosphorylation | RTEGGPSSEMSTSMK CCCCCCCHHHCHHCC | 40.21 | 22369663 | |
| 851 | Phosphorylation | GGPSSEMSTSMKRND CCCCHHHCHHCCCCC | 17.18 | 22369663 | |
| 852 | Phosphorylation | GPSSEMSTSMKRNDA CCCHHHCHHCCCCCC | 31.37 | 22369663 | |
| 853 | Phosphorylation | PSSEMSTSMKRNDAT CCHHHCHHCCCCCCC | 18.26 | 22369663 | |
| 869 | Phosphorylation | NQELDKNSTELLNYL CHHHCCCHHHHHHHH | 29.06 | 28889911 | |
| 885 | Phosphorylation | PKPLNDGYENISNKD CCCCCCCCCCCCCCC | 14.52 | 22369663 | |
| 889 | Phosphorylation | NDGYENISNKDSSHE CCCCCCCCCCCCHHH | 49.78 | 22369663 | |
| 893 | Phosphorylation | ENISNKDSSHELLNI CCCCCCCCHHHHHHH | 34.89 | 22369663 | |
| 894 | Phosphorylation | NISNKDSSHELLNIL CCCCCCCHHHHHHHH | 30.99 | 22369663 | |
| 924 | Phosphorylation | TDGYSLASDNNENSS CCCCCCCCCCCCCHH | 46.28 | 28889911 | |
| 930 | Phosphorylation | ASDNNENSSNKLLNM CCCCCCCHHHHHHHH | 29.16 | 21551504 | |
| 931 | Phosphorylation | SDNNENSSNKLLNML CCCCCCHHHHHHHHH | 49.95 | 27017623 | |
| 942 | Phosphorylation | LNMLQNRSSAINEPN HHHHHCHHHHHCCCC | 31.50 | 28889911 | |
| 943 | Phosphorylation | NMLQNRSSAINEPNF HHHHCHHHHHCCCCC | 29.90 | 19779198 | |
| 954 | Phosphorylation | EPNFDVRSNGTSGSN CCCCCCCCCCCCCHH | 39.19 | 21440633 | |
| 957 | Phosphorylation | FDVRSNGTSGSNELL CCCCCCCCCCHHHHH | 33.88 | 23749301 | |
| 958 | Phosphorylation | DVRSNGTSGSNELLS CCCCCCCCCHHHHHH | 41.44 | 22369663 | |
| 960 | Phosphorylation | RSNGTSGSNELLSIL CCCCCCCHHHHHHHH | 27.22 | 22369663 | |
| 965 | Phosphorylation | SGSNELLSILHRK-- CCHHHHHHHHCCC-- | 35.41 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DCP2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DCP2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCP2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116; SER-319; SER-320;SER-438; SER-577; SER-584; SER-598; SER-682; THR-686; SER-691;THR-710; SER-728; SER-729; SER-730; SER-747; SER-751; SER-783;THR-784; SER-786; SER-836 AND SER-942, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-710; SER-713; SER-729AND SER-958, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-679 AND SER-751, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-607; SER-608; SER-682AND SER-778, AND MASS SPECTROMETRY. | |
