TCB1_YEAST - dbPTM
TCB1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCB1_YEAST
UniProt AC Q12466
Protein Name Tricalbin-1
Gene Name TCB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1186
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description May play a role in membrane trafficking..
Protein Sequence MAKEDTGVTAPKKPETAQVANINGIDKLEPPKTKEETESSKSVSSEKAAHASDESFKRSIHEASYVGWKQIGGWEDKDELTLDDELMDMTRETFLDNIIPDSLYGDWYHSVAIFFIGGVASFALGHYKFSMGSAFFVIVITSLLYRTSAKKYRGSIRELVQKEFTVQKVENDYESLEWLNAFLDKYWPILEPSVSQLIVQQANEQMATNEAIPKFITQLWIDELTLGVKPPRVDLVKTFQNTASDVVVMDWGISFTPHDLCDMSAKQVRNYVNELAVVKAKIFGITIPVSVSDIAFKAHARVKFKLMTPFPHVETVNIQLLKVPDFDFVATLFGRSIFNWEILAIPGLMTLIQKMAKKYMGPILLPPFSLQLNIPQLLSGSNLSIGILEITVKNAKGLKRTSSILNESIDPYLSFEFNDISIAKTRTVRDTLNPVWDETLYVLLNSFTDPLTISVYDKRAKLKDKVLGRIQYNLNTLHDKTTQRNLKAQFLRNSKPVGELTFDLRFFPTLEEKKLPDGSVEELPDLNTGIAKVVVEEGSRFAEEEQKVTAYVEVYLNAKLVLTTGKATDTGTLKWNSDYEAVIADRRKTRYKFVVKDGKGEEIGSTIQTLNDLIDRSQVNKNLIPLKNQKGDIKITTYWRPVRLEIGSNSVAYTPPIGAIRVFIEKANDLRNLEKFGTIDPYCKVLVNGLSKGRTDFKSQTLNPVWNQVIYVAVTSPNQRITLQCMDVETVNKDRSLGEFNVNVQDLFKKDENDKYEETIDEKAKVGRLVMPKKKPKGTITYYTSFYPALPVLTLEEIQDLDKVNKKKKALELRKSAIDEKKISKEDKAKFDQEWNEVKELEDMYSNRQKLDLPELLQYNQGVLAVTVLNGELPDSGLYVQAFFDDNGHPRFVSPRIPSRIVKNGWSGDVIIKELDKSITTFRVAKNKNYNRVEKCVCEVELPTQELVKNCYYKPSILHLSGEGSAKLMLQISWFPIDTKQLPANDLITNSGDLTIMSRSAENLIASDLNGYSDPYLKYYINNEEDCAYKTKVVKKTLNPKWNDEGTIQINNRLNDVLRIKVMDWDSTSADDTIGTAEIPLNKVKVEGTTELDVPVEGLENAGQDGGMLHLAFSFKPRYTISVSKREKKVGDIASKGLGTGLKAGTTVIGGGVGAIGKIKKGVFGGLGSLTNHKKNHEMGEEETKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationPPKTKEETESSKSVS
CCCCHHHCCCCCCCC		42.1127717283
39PhosphorylationKTKEETESSKSVSSE
CCHHHCCCCCCCCHH		50.9527717283
40PhosphorylationTKEETESSKSVSSEK
CHHHCCCCCCCCHHH		23.7927717283
42PhosphorylationEETESSKSVSSEKAA
HHCCCCCCCCHHHHH		29.2227717283
44PhosphorylationTESSKSVSSEKAAHA
CCCCCCCCHHHHHHC		39.6128889911
45PhosphorylationESSKSVSSEKAAHAS
CCCCCCCHHHHHHCC		40.7528889911
52PhosphorylationSEKAAHASDESFKRS
HHHHHHCCCHHHHHH		31.8524961812
55PhosphorylationAAHASDESFKRSIHE
HHHCCCHHHHHHHHH		40.8524961812
59PhosphorylationSDESFKRSIHEASYV
CCHHHHHHHHHHHCC		28.9628889911
142PhosphorylationFFVIVITSLLYRTSA
HHHHHHHHHHHHHCC		12.7828889911
145PhosphorylationIVITSLLYRTSAKKY
HHHHHHHHHHCCHHH		19.6928889911
408PhosphorylationTSSILNESIDPYLSF
HHHHHHCCCCCCCCE		31.0821440633
412PhosphorylationLNESIDPYLSFEFND
HHCCCCCCCCEEECC		15.9528132839
480AcetylationNLNTLHDKTTQRNLK
HHHHCCCHHHHHHHH		42.6024489116
513UbiquitinationFFPTLEEKKLPDGSV
ECCCCCCCCCCCCCH		50.6817644757
513AcetylationFFPTLEEKKLPDGSV
ECCCCCCCCCCCCCH		50.6824489116
514UbiquitinationFPTLEEKKLPDGSVE
CCCCCCCCCCCCCHH		69.4117644757
532UbiquitinationDLNTGIAKVVVEEGS
CCCCCCEEEEEECCC		33.3717644757
566UbiquitinationKLVLTTGKATDTGTL
EEEEEECCCCCCCEE		46.1223749301
666UbiquitinationAIRVFIEKANDLRNL
EEEEEHHHHHHHCCH		47.9023749301
6662-HydroxyisobutyrylationAIRVFIEKANDLRNL
EEEEEHHHHHHHCCH		47.90-
666AcetylationAIRVFIEKANDLRNL
EEEEEHHHHHHHCCH		47.9024489116
692UbiquitinationVLVNGLSKGRTDFKS
HHHCCCCCCCCCCCC		58.4123749301
698UbiquitinationSKGRTDFKSQTLNPV
CCCCCCCCCCCCCCC		44.4517644757
830AcetylationISKEDKAKFDQEWNE
CCHHHHHHHHHHHHH		56.0424489116
845PhosphorylationVKELEDMYSNRQKLD
HHHHHHHHHCCCCCC		18.3428889911
846PhosphorylationKELEDMYSNRQKLDL
HHHHHHHHCCCCCCH		20.9228889911
917AcetylationVIIKELDKSITTFRV
EEEEEHHHCCCEEEE		57.2824489116
918PhosphorylationIIKELDKSITTFRVA
EEEEHHHCCCEEEEE		25.4924961812
920PhosphorylationKELDKSITTFRVAKN
EEHHHCCCEEEEECC		27.2924961812
921PhosphorylationELDKSITTFRVAKNK
EHHHCCCEEEEECCC		14.0524961812
952PhosphorylationQELVKNCYYKPSILH
HHHHHHCCCCCEEEE		24.7429688323
953PhosphorylationELVKNCYYKPSILHL
HHHHHCCCCCEEEEE		20.7229688323
954AcetylationLVKNCYYKPSILHLS
HHHHCCCCCEEEEEC		13.0524489116
956PhosphorylationKNCYYKPSILHLSGE
HHCCCCCEEEEECCC		33.3629688323
961PhosphorylationKPSILHLSGEGSAKL
CCEEEEECCCCCEEE		24.8529688323
965PhosphorylationLHLSGEGSAKLMLQI
EEECCCCCEEEEEEE		20.2329688323
1000PhosphorylationDLTIMSRSAENLIAS
CEEEECCCHHHHCCC		32.4022369663
1007PhosphorylationSAENLIASDLNGYSD
CHHHHCCCCCCCCCC		35.3222369663
1012PhosphorylationIASDLNGYSDPYLKY
CCCCCCCCCCCCHHH		14.6122369663
1013PhosphorylationASDLNGYSDPYLKYY
CCCCCCCCCCCHHHH		33.2422369663
1016PhosphorylationLNGYSDPYLKYYINN
CCCCCCCCHHHHCCC		22.3322369663
1018UbiquitinationGYSDPYLKYYINNEE
CCCCCCHHHHCCCCC		30.1117644757
1030AcetylationNEEDCAYKTKVVKKT
CCCHHHHCCEEEEEC		24.2824489116
1041AcetylationVKKTLNPKWNDEGTI
EEECCCCCCCCCCEE		58.5224489116
1061UbiquitinationLNDVLRIKVMDWDST
CCCEEEEEEECCCCC		25.6923749301
1067PhosphorylationIKVMDWDSTSADDTI
EEEECCCCCCCCCCE		21.7321440633
1068PhosphorylationKVMDWDSTSADDTIG
EEECCCCCCCCCCEE		26.0128889911
1069PhosphorylationVMDWDSTSADDTIGT
EECCCCCCCCCCEEE		33.3821440633
1073PhosphorylationDSTSADDTIGTAEIP
CCCCCCCCEEEEECC		23.1230377154
1135PhosphorylationKKVGDIASKGLGTGL
EEHHHHHHCCCCCCC		27.8225752575
1146PhosphorylationGTGLKAGTTVIGGGV
CCCCCCCCEEECCCC		23.8121440633
1147PhosphorylationTGLKAGTTVIGGGVG
CCCCCCCEEECCCCC		14.8124930733
1161UbiquitinationGAIGKIKKGVFGGLG
CHHHHHCCCCCCCHH		64.8717644757
1169PhosphorylationGVFGGLGSLTNHKKN
CCCCCHHHHCCHHHC		36.7421440633
1171PhosphorylationFGGLGSLTNHKKNHE
CCCHHHHCCHHHCCC		36.6524961812
1174UbiquitinationLGSLTNHKKNHEMGE
HHHHCCHHHCCCCCC		58.2917644757
1175UbiquitinationGSLTNHKKNHEMGEE
HHHCCHHHCCCCCCC		56.8617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCB1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCB1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCB1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCB3_YEASTTCB3genetic
15141306
RSP5_YEASTRSP5genetic
15141306
EF3A_YEASTYEF3physical
16554755
TCB2_YEASTTCB2genetic
15141306
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
SSB1_YEASTSSB1physical
22940862
HSP71_YEASTSSA1physical
22940862
DED1_YEASTDED1physical
22940862
MPG1_YEASTPSA1physical
22940862
TCB1_YEASTTCB1physical
22940862
PALH_YEASTRIM21genetic
27803246
ACL4_YEASTYDR161Wgenetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
DMA2_YEASTDMA2genetic
27708008
POP7_YEASTPOP7genetic
27708008
FAL1_YEASTFAL1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
TAF1_YEASTTAF1genetic
27708008
AFG2_YEASTAFG2genetic
27708008
TFC8_YEASTTFC8genetic
27708008
IF6_YEASTTIF6genetic
27708008
CG13_YEASTCLN3genetic
27708008
ECM8_YEASTECM8genetic
27708008
GLYM_YEASTSHM1genetic
27708008
ATG22_YEASTATG22genetic
27708008
TAH1_YEASTTAH1genetic
27708008
MGMT_YEASTMGT1genetic
27708008
VHS1_YEASTVHS1genetic
27708008
SNX41_YEASTSNX41genetic
27708008
FIT1_YEASTFIT1genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
GTR2_YEASTGTR2genetic
27708008
FYV8_YEASTFYV8genetic
27708008
YIK8_YEASTYIL108Wgenetic
27708008
VPS53_YEASTVPS53genetic
27708008
ELM1_YEASTELM1genetic
27708008
MBR1_YEASTMBR1genetic
27708008
FEN1_YEASTRAD27genetic
27708008
MEH1_YEASTMEH1genetic
27708008
BCH2_YEASTBCH2genetic
27708008
PET10_YEASTPET10genetic
27708008
PUF3_YEASTPUF3genetic
27708008
YL012_YEASTYLR012Cgenetic
27708008
BMT6_YEASTBMT6genetic
27708008
TMA10_YEASTTMA10genetic
27708008
SRR1L_YEASTBER1genetic
27708008
NIS1_YEASTNIS1genetic
27708008
YN93_YEASTYNR064Cgenetic
27708008
MET22_YEASTMET22genetic
27708008
RTC1_YEASTRTC1genetic
27708008
LGE1_YEASTLGE1genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCB1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000, AND MASSSPECTROMETRY.

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