MBR1_YEAST - dbPTM
MBR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MBR1_YEAST
UniProt AC P23493
Protein Name Mitochondrial biogenesis regulation protein 1
Gene Name MBR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 339
Subcellular Localization Mitochondrion .
Protein Description Participates in mitochondrial biogenesis and stress response..
Protein Sequence MRMEKTTDKPLSAGDMNDEYSRGPIDDIDCLNFFERAVQDPCCEACDTEDADEELRAKLSSFNFQPDSSPCNAKCQQTLNPLCKIDEALPAESELAPSRNGSVSEANSDTNSIASTVHDPVDSKYGGMPSLRKAKTTSYFTSSSSNNTTMRNPLKKCNTNINGLLVNGRSSSSSRQSIPELFSGACTKKKNNVLLKSETPNSEFSSNSLQHCNSRSFSLPRSRSRSSAIAIPTHLYGLEKYVSPGLDTLTADPEESIERFSNNRPREISSCCPNDTGDTSSSLSHSNTSSSLNFPLGTNTNQFHQPRQPVQQQQSSKPNFGAGRKKSFIEMSLASSFAG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68PhosphorylationSFNFQPDSSPCNAKC
HCCCCCCCCCCCCHH		42.7519779198
69PhosphorylationFNFQPDSSPCNAKCQ
CCCCCCCCCCCCHHH		40.6327214570
98PhosphorylationAESELAPSRNGSVSE
CCCCCCCCCCCCCCC		32.5425005228
102PhosphorylationLAPSRNGSVSEANSD
CCCCCCCCCCCCCCC		26.4722369663
104PhosphorylationPSRNGSVSEANSDTN
CCCCCCCCCCCCCCC		32.4621440633
108PhosphorylationGSVSEANSDTNSIAS
CCCCCCCCCCCCHHH		53.5122369663
110PhosphorylationVSEANSDTNSIASTV
CCCCCCCCCCHHHHC		30.5922369663
112PhosphorylationEANSDTNSIASTVHD
CCCCCCCCHHHHCCC		22.9423749301
115PhosphorylationSDTNSIASTVHDPVD
CCCCCHHHHCCCCCC		29.3219779198
116PhosphorylationDTNSIASTVHDPVDS
CCCCHHHHCCCCCCC		16.9122369663
123PhosphorylationTVHDPVDSKYGGMPS
HCCCCCCCCCCCCCC		28.1922369663
136PhosphorylationPSLRKAKTTSYFTSS
CCCCCCEECCCCCCC		26.3222369663
137PhosphorylationSLRKAKTTSYFTSSS
CCCCCEECCCCCCCC		22.2622369663
138PhosphorylationLRKAKTTSYFTSSSS
CCCCEECCCCCCCCC		24.3922369663
139PhosphorylationRKAKTTSYFTSSSSN
CCCEECCCCCCCCCC		14.5822369663
141PhosphorylationAKTTSYFTSSSSNNT
CEECCCCCCCCCCCC		21.3322369663
142PhosphorylationKTTSYFTSSSSNNTT
EECCCCCCCCCCCCE		20.5119779198
143PhosphorylationTTSYFTSSSSNNTTM
ECCCCCCCCCCCCEE		34.4322369663
144PhosphorylationTSYFTSSSSNNTTMR
CCCCCCCCCCCCEEC		36.5322369663
145PhosphorylationSYFTSSSSNNTTMRN
CCCCCCCCCCCEECC		35.7322369663
148PhosphorylationTSSSSNNTTMRNPLK
CCCCCCCCEECCCHH		26.6422369663
149PhosphorylationSSSSNNTTMRNPLKK
CCCCCCCEECCCHHH		19.0922369663
159PhosphorylationNPLKKCNTNINGLLV
CCHHHCCCCCCCEEE		47.1222369663
170PhosphorylationGLLVNGRSSSSSRQS
CEEECCCCCCCCCCC		35.6522369663
171PhosphorylationLLVNGRSSSSSRQSI
EEECCCCCCCCCCCH		32.6423749301
172PhosphorylationLVNGRSSSSSRQSIP
EECCCCCCCCCCCHH		33.3122369663
173PhosphorylationVNGRSSSSSRQSIPE
ECCCCCCCCCCCHHH		31.3322369663
174PhosphorylationNGRSSSSSRQSIPEL
CCCCCCCCCCCHHHH		35.9722369663
177PhosphorylationSSSSSRQSIPELFSG
CCCCCCCCHHHHHCC		38.7122369663
183PhosphorylationQSIPELFSGACTKKK
CCHHHHHCCCCCCCC		37.8022369663
187PhosphorylationELFSGACTKKKNNVL
HHHCCCCCCCCCCEE		45.4222369663
199PhosphorylationNVLLKSETPNSEFSS
CEEEECCCCCCCCCC		34.5630377154
205PhosphorylationETPNSEFSSNSLQHC
CCCCCCCCCCCHHHH		25.2622369663
206PhosphorylationTPNSEFSSNSLQHCN
CCCCCCCCCCHHHHH		35.4422369663
208PhosphorylationNSEFSSNSLQHCNSR
CCCCCCCCHHHHHCC		31.2122369663
214PhosphorylationNSLQHCNSRSFSLPR
CCHHHHHCCCCCCCC		34.3922369663
216PhosphorylationLQHCNSRSFSLPRSR
HHHHHCCCCCCCCCC		21.0029136822
218PhosphorylationHCNSRSFSLPRSRSR
HHHCCCCCCCCCCCH		38.4229136822
222PhosphorylationRSFSLPRSRSRSSAI
CCCCCCCCCCHHCCE		32.4428889911
224PhosphorylationFSLPRSRSRSSAIAI
CCCCCCCCHHCCEEC		37.4522369663
226PhosphorylationLPRSRSRSSAIAIPT
CCCCCCHHCCEECCH		25.9322369663
227PhosphorylationPRSRSRSSAIAIPTH
CCCCCHHCCEECCHH		23.6822369663
243PhosphorylationYGLEKYVSPGLDTLT
HCHHHHCCCCCCCCC		15.3428889911
256PhosphorylationLTADPEESIERFSNN
CCCCHHHHHHHHHCC		28.2530377154
269PhosphorylationNNRPREISSCCPNDT
CCCCCCHHHCCCCCC		16.7519779198
276PhosphorylationSSCCPNDTGDTSSSL
HHCCCCCCCCCCCCC		43.5319779198
327PhosphorylationFGAGRKKSFIEMSLA
CCCCCCHHHHHHHHH		34.2029650682
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MBR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MBR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MBR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCH9_YEASTSCH9genetic
9267436
SOK1_YEASTSOK1genetic
9267436
NDH2_YEASTNDE2physical
16554755
YJL8_YEASTYJL118Wphysical
16554755
PIG1_YEASTPIG1physical
16554755
PRR2_YEASTPRR2genetic
20093466
MTU1_YEASTSLM3genetic
20093466
RAD57_YEASTRAD57genetic
20093466
CSN9_YEASTCSN9genetic
20093466
MNN10_YEASTMNN10genetic
20093466
LSM6_YEASTLSM6genetic
20093466
PEA2_YEASTPEA2genetic
20093466
YOR1_YEASTYOR1genetic
20093466
COPE_YEASTSEC28genetic
20093466
SSO2_YEASTSSO2genetic
20093466
ADE_YEASTAAH1genetic
20093466
CY1_YEASTCYT1genetic
20093466
BUD21_YEASTBUD21genetic
20093466
BEM4_YEASTBEM4genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
KAR3_YEASTKAR3genetic
20093466
QCR2_YEASTQCR2genetic
20093466
RS8A_YEASTRPS8Agenetic
21987634
RS8B_YEASTRPS8Agenetic
21987634
DOP1_YEASTDOP1genetic
21987634
MS116_YEASTMSS116genetic
21987634
ISC1_YEASTISC1genetic
21987634
ATC1_YEASTPMR1genetic
21987634
GEP4_YEASTGEP4genetic
21987634
ODO1_YEASTKGD1genetic
21987634
PT130_YEASTPET130genetic
21987634
ATP12_YEASTATP12genetic
21987634
KAPC_YEASTTPK3genetic
21987634
MMM1_YEASTMMM1genetic
21987634
CDC42_YEASTCDC42genetic
21987634
ACON_YEASTACO1genetic
21987634
GATA_YEASTHER2genetic
21987634
JJJ1_YEASTJJJ1genetic
21987634
GEP3_YEASTGEP3genetic
21987634
AVT5_YEASTAVT5genetic
27708008
ERV15_YEASTERV15genetic
27708008
MTU1_YEASTSLM3genetic
27708008
DOT1_YEASTDOT1genetic
27708008
PEA2_YEASTPEA2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ASF1_YEASTASF1genetic
27708008
DID2_YEASTDID2genetic
27708008
MMM1_YEASTMMM1genetic
27708008
PET8_YEASTPET8genetic
27708008
CY1_YEASTCYT1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MBR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-227, ANDMASS SPECTROMETRY.

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