PIG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIG1_YEAST
• UniProt AC: Q06216
• Protein Name: Serine/threonine-protein phosphatase 1 regulatory subunit PIG1
• Gene Name: PIG1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 648
• Protein Description: Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1..
• Protein Sequence: MPYSHGKKLKPSLKLAKTISTSSFVSSTTSNSFSPLEDSTSASSSTSSSSSGKSVRFAAHLYTVKKFNTKLAPISISEKAASNLTRNLHNNAIPLTFPFIGGEDHRYSLDILDYSDLEYDNKDVEYDNESDVEDNAMLMHDRSMFIEKEILCFGEEETFDMADWKLVSNNLNPFKSDYKVDVTGLEDKIFKYLNGQNIKVHSLELSDPVSYEDICSNNFGNCQIWGLIFVNNLNFEKKIEIKFTLNNWADIHYINAHYNKSVTPHVDEFKFIIDISALKLNLISKNLIYTNFFERKTTCLLNLQFCCRYDVNGFEYRSFYDNNDYKNYEITISLSAINLNRAVSNSSIFNSNLGPSKMGASNAEVTMSKNNENSKKPLRKFIKDTDYYNDSPLKHKFYQSFETKAACKTEPVSQTFKAETIDCEIEPFNYFFEPPDSQTNEDMSDSSYDLSLQDFNYWEFSNHGLGKALADSDILQFKNYPKPEPFSRPPIIDDTFTLNTDDRTLGSKTQKLEDNLAKEWKSAKTRTTLNETPLHDDEHRTSFTYTTWNNSTDTLMKRKEERPVESASCSQLSIATIKAEEDLLYQDYINSGRESSSPEISPLNTTTSLPFFPGDNMSDSSGEYEERTSLSPNKIHIFRDYFYKSPSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Ubiquitination	APISISEKAASNLTR ECCCCCHHHHHHCCH	42.32	24961812
130	Phosphorylation	DVEYDNESDVEDNAM CCCCCCCCCCCHHHH	53.89	27214570
385	Phosphorylation	LRKFIKDTDYYNDSP HHHHHCCCCCCCCCC	22.39	19684113
387	Phosphorylation	KFIKDTDYYNDSPLK HHHCCCCCCCCCCCC	13.27	19684113
388	Phosphorylation	FIKDTDYYNDSPLKH HHCCCCCCCCCCCCH	18.46	19684113
391	Phosphorylation	DTDYYNDSPLKHKFY CCCCCCCCCCCHHHH	28.61	19684113
568	Phosphorylation	ERPVESASCSQLSIA CCCCCCCCCCEEEEE	24.47	28889911
573	Phosphorylation	SASCSQLSIATIKAE CCCCCEEEEEEEEEH	11.53	28889911
576	Phosphorylation	CSQLSIATIKAEEDL CCEEEEEEEEEHHHH	22.72	28889911
631	Phosphorylation	YEERTSLSPNKIHIF CCCCCCCCCCEEEEE	26.62	19779198
645	Phosphorylation	FRDYFYKSPSP---- EEHHCCCCCCC----	21.16	28889911
647	Phosphorylation	DYFYKSPSP------ HHCCCCCCC------	50.78	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIG1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAC1_YEAST	GAC1	genetic	9046081
ERR1_YEAST	ERR1	physical	18467557
ERR2_YEAST	ERR1	physical	18467557
STE20_YEAST	STE20	genetic	19269370
RPC6_YEAST	RPC34	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.