PRR2_YEAST - dbPTM
PRR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRR2_YEAST
UniProt AC Q12310
Protein Name Serine/threonine-protein kinase PRR2
Gene Name PRR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 699
Subcellular Localization
Protein Description Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling..
Protein Sequence MSLSRILRYNQRNNKTTASLTAEHAYSDNWAYSVSLGDPTSVGVNMAAKTGEALNKSYDSVFSSLPVADSVPRTDFTASSRDDENTDVQKLTTSWMEKIDTKMPENISKIDSNIISSPMVSKVEARFIVPKGRLRKNSTDFTSSFSNSLSLPKSYGKLIFFTSKKNSSSTKKNLANDISDNKHNNNSSNTIGHNIPVTTATATCDEIACTSTEHEYNVYEEERMFTTRVYSLEDSVSSLSTNPLDDTYSEAVQVNTRHIEDTESTAHIRKHSYTTSLSSIKRLFKITSFSNNNSNSCDHQESTVADDCAISSSLKETTSSPVSTGSFSLMIENEDSDRDQIIQALYSNIEASTDLVSRKYRDLDVVLGEGSGGKVKLVQRVLDNKVFALKEYRSKKKRESERKYIKNIISEYCIASTLKNPNICETLEILYEKGKIFQILEYCEYDLFSLVMSEKMHYEEICCLFKQLINGVKYLHDIGLSHRDLKLDNCVVTRRGILKLIDFGASSVFHYPLSSQMIEANGIVGSDPYLSPEVFYFNEYDPRALDVWSVGIIFFCMITRRFPWKYPKVKDVQFKAFCSGRGVSSFKDLVTRPATDDSNNYDNDGYEEGVIDMGPNFILHRLPEETHKIMRRILEVSPFRRITINGILQDGWIKEIETCQVVGAASPNEASLRIINKGNHIHTNIDQRYAHIGGLHQRT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
57PhosphorylationTGEALNKSYDSVFSS
HHHHHHHHHHHHHHC		32.8528889911
63PhosphorylationKSYDSVFSSLPVADS
HHHHHHHHCCCCCCC		28.8928889911
64PhosphorylationSYDSVFSSLPVADSV
HHHHHHHCCCCCCCC		25.8128889911
112PhosphorylationENISKIDSNIISSPM
CCHHHCCCCCCCCCC		33.1428889911
138PhosphorylationKGRLRKNSTDFTSSF
CCCCCCCCCCCCHHC		32.1828889911
150PhosphorylationSSFSNSLSLPKSYGK
HHCCCCCCCCHHHCE		42.3128889911
231PhosphorylationMFTTRVYSLEDSVSS
CEEEEEEEHHHHHHH		23.5628889911
410PhosphorylationKYIKNIISEYCIAST
HHHHHHHHHHHHHHC		20.7927017623
412PhosphorylationIKNIISEYCIASTLK
HHHHHHHHHHHHCCC		5.1627017623
416PhosphorylationISEYCIASTLKNPNI
HHHHHHHHCCCCCCH		17.8627017623
449PhosphorylationYCEYDLFSLVMSEKM
HHHHHHHHHHHCCCC		27.6127017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLA1_YEASTSLA1physical
16319894
KKQ8_YEASTKKQ8physical
16319894
VPS27_YEASTVPS27physical
16319894
CDC15_YEASTCDC15physical
16319894
PHO90_YEASTPHO90physical
16319894
GZF3_YEASTGZF3physical
16319894
YMI3_YEASTYML083Cphysical
16319894
SAS10_YEASTSAS10physical
16319894
REXO1_YEASTRNH70physical
16319894
SOL2_YEASTSOL2physical
16319894
YMD7_YEASTYML037Cphysical
16319894
PAH1_YEASTPAH1physical
16319894
IRC8_YEASTIRC8physical
16319894
CDC13_YEASTCDC13physical
16319894
NCL1_YEASTNCL1physical
16319894
YMZ2_YEASTYMR102Cphysical
16319894
INP54_YEASTINP54physical
16319894
PHS_YEASTYHL018Wphysical
16319894
KIN3_YEASTKIN3physical
16319894
SRP40_YEASTSRP40physical
16319894
MGA1_YEASTMGA1physical
16319894
6P21_YEASTPFK26physical
16319894
PDP2_YEASTPTC6physical
16319894
SS100_YEASTSPS100physical
16319894
JJJ1_YEASTJJJ1physical
16319894
SIP5_YEASTSIP5physical
16319894
LSM12_YEASTLSM12physical
16319894
VMA22_YEASTVMA22physical
16319894
ATG29_YEASTATG29physical
16319894
URA8_YEASTURA8physical
16319894
HOSM_YEASTLYS21physical
16319894
PRP40_YEASTPRP40physical
16319894
PDX3_YEASTPDX3physical
16319894
AAR2_YEASTAAR2physical
16319894
VATC_YEASTVMA5physical
16319894
KHSE_YEASTTHR1genetic
19269370
PLMT_YEASTOPI3genetic
19269370
ADR1_YEASTADR1physical
20489023
CSM1_YEASTCSM1physical
20489023
LRS4_YEASTLRS4physical
20489023
MPM1_YEASTMPM1physical
20489023
PRM7_YEASTPRM7physical
16319894
RAD23_YEASTRAD23physical
21460040
REI1_YEASTREI1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
FLO10_YEASTFLO10genetic
22282571
YP260_YEASTYPL260Wgenetic
22282571
ATG1_YEASTATG1genetic
22282571
NRG1_YEASTNRG1genetic
22282571
UBP16_YEASTUBP16genetic
22282571
GAP1_YEASTGAP1genetic
22282571
MSA1_YEASTMSA1genetic
22282571
YO029_YEASTYOL029Cgenetic
22282571
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRR2_YEAST

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Related Literatures of Post-Translational Modification

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