URA8_YEAST - dbPTM
URA8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID URA8_YEAST
UniProt AC P38627
Protein Name CTP synthase 2
Gene Name URA8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 578
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis..
Protein Sequence MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGITLSRDHNITTGKIYSHVISRERRGDYLGKTVQIVPHLTNAIQDWIQRVSKIPVDDTGLEPDVCIIELGGTVGDIESAPFVEALRQFQFEVGRENFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLIPDMIACRCSEELNRSTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQHMIDYLHSRLKLGEVPLTLEDKERGSQLLTNWENMTKNLDDSDDVVKIALVGKYTNLKDSYLSVTKSLEHASMKCRRQLEILWVEASNLEPETQEVDKNKFHDSWNKLSSADGILVPGGFGTRGIEGMILAAKWARESGVPFLGVCLGLQVAAIEFARNVIGRPNSSSTEFLDETLLAPEDQVVIYMPEIDKEHMGGTMRLGLRPTIFQPNSEWSNIRKLYGEVNEVHERHRHRYEINPKIVNDMESRGFIFVGKDETGQRCEIFELKGHPYYVGTQYHPEYTSKVLEPSRPFWGLVAAASGTLGEVIKDINLSEGNENE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MKYVVVSGGV
-----CCEEEEECCE		9.3621126336
7Phosphorylation-MKYVVVSGGVISGI
-CCEEEEECCEECCC		20.4421126336
33UbiquitinationLLKTLGLKVTSIKID
HHHHHCCEEEEEEEC		41.4923749301
36PhosphorylationTLGLKVTSIKIDPYM
HHCCEEEEEEECCCC		25.5228889911
77PhosphorylationDLGNYERYLGITLSR
ECCCCCHHCCEEEEC		9.4222369663
81PhosphorylationYERYLGITLSRDHNI
CCHHCCEEEECCCCC		19.5122369663
94PhosphorylationNITTGKIYSHVISRE
CCCCCCEEEEECCCH		9.0122369663
95PhosphorylationITTGKIYSHVISRER
CCCCCEEEEECCCHH		18.1022369663
99PhosphorylationKIYSHVISRERRGDY
CEEEEECCCHHCCCC		27.3122369663
193UbiquitinationIHGEQKTKPTQAAIK
ECCCCCCCCCHHHHH		53.7723749301
269AcetylationDYLHSRLKLGEVPLT
HHHHHHHCCCCCCCC		54.0224489116
311UbiquitinationVKIALVGKYTNLKDS
EEEEEEEECCCCHHH		41.2324961812
3112-HydroxyisobutyrylationVKIALVGKYTNLKDS
EEEEEEEECCCCHHH		41.23-
312PhosphorylationKIALVGKYTNLKDSY
EEEEEEECCCCHHHH		8.5719823750
313PhosphorylationIALVGKYTNLKDSYL
EEEEEECCCCHHHHH		37.2519823750
316AcetylationVGKYTNLKDSYLSVT
EEECCCCHHHHHHHH		46.8524489116
318PhosphorylationKYTNLKDSYLSVTKS
ECCCCHHHHHHHHHC		26.7919823750
319PhosphorylationYTNLKDSYLSVTKSL
CCCCHHHHHHHHHCH		17.0919823750
321PhosphorylationNLKDSYLSVTKSLEH
CCHHHHHHHHHCHHH		21.3619823750
323PhosphorylationKDSYLSVTKSLEHAS
HHHHHHHHHCHHHHH		16.1319823750
324UbiquitinationDSYLSVTKSLEHASM
HHHHHHHHCHHHHHH		51.3824961812
345PhosphorylationEILWVEASNLEPETQ
EEEEEECCCCCCCCC		28.5724909858
351PhosphorylationASNLEPETQEVDKNK
CCCCCCCCCCCCHHH		40.5224909858
367PhosphorylationHDSWNKLSSADGILV
CCHHHHHHCCCEEEE		25.7028889911
368PhosphorylationDSWNKLSSADGILVP
CHHHHHHCCCEEEEC		40.5928889911
380PhosphorylationLVPGGFGTRGIEGMI
EECCCCCCCCHHHHH		24.3828889911
513UbiquitinationRGFIFVGKDETGQRC
CCEEEEEECCCCCEE		47.2724961812
513AcetylationRGFIFVGKDETGQRC
CCEEEEEECCCCCEE		47.2724489116
572PhosphorylationVIKDINLSEGNENE-
HHHHCCCCCCCCCC-		38.6828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of URA8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of URA8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of URA8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
URA7_YEASTURA7physical
11283351
URA8_YEASTURA8physical
11283351
URA7_YEASTURA7genetic
17284612
URA7_YEASTURA7genetic
18408719
URA7_YEASTURA7genetic
20093466
RV161_YEASTRVS161genetic
20093466
MNN10_YEASTMNN10genetic
20093466
RV167_YEASTRVS167genetic
20093466
HPRT_YEASTHPT1genetic
20093466
METE_YEASTMET6genetic
20093466
SCS2_YEASTSCS2genetic
20093466
CSK2B_YEASTCKB1genetic
20093466
MSP1_YEASTMSP1genetic
20093466
PACC_YEASTRIM101genetic
20093466
FIS1_YEASTFIS1genetic
20093466
MRX5_YEASTYJL147Cgenetic
20093466
SIC1_YEASTSIC1genetic
20093466
COA4_YEASTCOA4genetic
20093466
NST1_YEASTNST1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
URA7_YEASTURA7genetic
21623372
PHSG_YEASTGPH1genetic
21623372
TPS2_YEASTTPS2genetic
21623372
URA8_YEASTURA8physical
24771766
MSS18_YEASTMSS18genetic
27708008
URA7_YEASTURA7genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
SDC1_YEASTSDC1genetic
27708008
SCS2_YEASTSCS2genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
RL40A_YEASTRPL40Bgenetic
27708008
RL40B_YEASTRPL40Bgenetic
27708008
SIC1_YEASTSIC1genetic
27708008
FKS1_YEASTFKS1genetic
27708008
MSC1_YEASTMSC1genetic
27708008
COX7_YEASTCOX7genetic
27708008
PP2A4_YEASTPPG1genetic
27708008
HMI1_YEASTHMI1genetic
27708008
CY1_YEASTCYT1genetic
27708008
HAP5_YEASTHAP5genetic
27708008
LGE1_YEASTLGE1genetic
27708008
SULX_YEASTYPR003Cgenetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of URA8_YEAST

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Related Literatures of Post-Translational Modification

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