METE_YEAST - dbPTM
METE_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID METE_YEAST
UniProt AC P05694
Protein Name 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Gene Name MET6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 767
Subcellular Localization
Protein Description Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation..
Protein Sequence MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQYKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MVQSAVLGFPR
----CCCCHHCCCCC		14.6627214570
19UbiquitinationIGPNRELKKATEGYW
CCCCHHHHHHHCCCC		35.2917644757
20UbiquitinationGPNRELKKATEGYWN
CCCHHHHHHHCCCCC		73.4917644757
29UbiquitinationTEGYWNGKITVDELF
HCCCCCCEEEHHHHH		31.8017644757
37AcetylationITVDELFKVGKDLRT
EEHHHHHHCCCCHHH		63.8024489116
48AcetylationDLRTQNWKLQKEAGV
CHHHCCCHHHHHHCC		48.9024489116
48SuccinylationDLRTQNWKLQKEAGV
CHHHCCCHHHHHHCC		48.9023954790
85AcetylationVIPDRYTKYDLSPID
CCCCCCCCCCCCHHH		28.0324489116
89PhosphorylationRYTKYDLSPIDTLFA
CCCCCCCCHHHHHHH		19.5322369663
93PhosphorylationYDLSPIDTLFAMGRG
CCCCHHHHHHHHCCC		25.2122369663
106PhosphorylationRGLQRKATETEKAVD
CCHHHHCCHHHHCCC		46.6121440633
110AcetylationRKATETEKAVDVTAL
HHCCHHHHCCCHHHH		62.2224489116
110UbiquitinationRKATETEKAVDVTAL
HHCCHHHHCCCHHHH		62.2224961812
121AcetylationVTALEMVKWFDSNYH
HHHHHHHHHHCCCCC		40.6124489116
121UbiquitinationVTALEMVKWFDSNYH
HHHHHHHHHHCCCCC		40.6123749301
125PhosphorylationEMVKWFDSNYHYVRP
HHHHHHCCCCCEECC		29.7924961812
133PhosphorylationNYHYVRPTFSKTTQF
CCCEECCCCCCEEEC		29.9424961812
135PhosphorylationHYVRPTFSKTTQFKL
CEECCCCCCEEECEE		31.4124961812
136AcetylationYVRPTFSKTTQFKLN
EECCCCCCEEECEEC		51.9424489116
136UbiquitinationYVRPTFSKTTQFKLN
EECCCCCCEEECEEC		51.9417644757
141AcetylationFSKTTQFKLNGQKPV
CCCEEECEECCCCCH		31.0924489116
146AcetylationQFKLNGQKPVDEFLE
ECEECCCCCHHHHHH		48.7017397211
146UbiquitinationQFKLNGQKPVDEFLE
ECEECCCCCHHHHHH		48.7023749301
155AcetylationVDEFLEAKELGIHTR
HHHHHHHHHHCCCCC		44.0624489116
176UbiquitinationVSYLFLGKADKDSLD
CCEEECCCCCCCCCC		56.4017644757
179UbiquitinationLFLGKADKDSLDLEP
EECCCCCCCCCCCCH		54.8217644757
203UbiquitinationLYTEILSKLASAGAT
HHHHHHHHHHHCCCC		44.6317644757
232SuccinylationANAQAAIKKAYTYFG
CCHHHHHHHHHHHHH		26.9923954790
232UbiquitinationANAQAAIKKAYTYFG
CCHHHHHHHHHHHHH		26.9917644757
233AcetylationNAQAAIKKAYTYFGE
CHHHHHHHHHHHHHC		40.2822865919
233UbiquitinationNAQAAIKKAYTYFGE
CHHHHHHHHHHHHHC		40.2823749301
242PhosphorylationYTYFGEQSNLPKITL
HHHHHCCCCCCCEEE		35.7128889911
246UbiquitinationGEQSNLPKITLATYF
HCCCCCCCEEEEHHC		52.0317644757
264UbiquitinationVPNLDAIKGLPVAAL
CCCHHHHCCCCEEEE		57.0017644757
292UbiquitinationVVAAIGNKQTLSVGI
HHHHHCCCCEEEEEE		39.1717644757
307AcetylationVDGRNIWKNDFKKSS
ECCCCCCCCCCHHHH		42.7322865919
3122-HydroxyisobutyrylationIWKNDFKKSSAIVNK
CCCCCCHHHHHHHHH		50.03-
313PhosphorylationWKNDFKKSSAIVNKA
CCCCCHHHHHHHHHH		26.1228889911
319AcetylationKSSAIVNKAIEKLGA
HHHHHHHHHHHHHCC		39.5924489116
319SuccinylationKSSAIVNKAIEKLGA
HHHHHHHHHHHHHCC		39.5923954790
3232-HydroxyisobutyrylationIVNKAIEKLGADRVV
HHHHHHHHHCCCEEE		46.22-
323AcetylationIVNKAIEKLGADRVV
HHHHHHHHHCCCEEE		46.2224489116
349AcetylationVDLNNETKLDAEIKG
CCCCCCCCCHHHHHH		37.8924489116
355UbiquitinationTKLDAEIKGFFSFAT
CCCHHHHHHHHHHHH		40.9617644757
359PhosphorylationAEIKGFFSFATQKLD
HHHHHHHHHHHCCCC		16.2321440633
364UbiquitinationFFSFATQKLDEVVVI
HHHHHHCCCCEEEEE		54.2517644757
373UbiquitinationDEVVVITKNVSGQDV
CEEEEEECCCCCHHH		44.2017644757
376PhosphorylationVVITKNVSGQDVAAA
EEEECCCCCHHHHHH		39.8828132839
389AcetylationAALEANAKSVESRGK
HHHHHHHHHHHHCCC		55.6424489116
389SuccinylationAALEANAKSVESRGK
HHHHHHHHHHHHCCC		55.6423954790
389UbiquitinationAALEANAKSVESRGK
HHHHHHHHHHHHCCC		55.6417644757
398AcetylationVESRGKSKFIHDAAV
HHHCCCHHHHHHHHH		52.3924489116
4062-HydroxyisobutyrylationFIHDAAVKARVASID
HHHHHHHHHHHHCCC		26.25-
406AcetylationFIHDAAVKARVASID
HHHHHHHHHHHHCCC		26.2522865919
411PhosphorylationAVKARVASIDEKMST
HHHHHHHCCCHHHHC		27.9329136822
415AcetylationRVASIDEKMSTRAAP
HHHCCCHHHHCCCCC		34.1124489116
415UbiquitinationRVASIDEKMSTRAAP
HHHCCCHHHHCCCCC		34.1123749301
432AcetylationQRLPEQQKVFNLPLF
HHCCHHHHHCCCCCC		48.7924489116
432SuccinylationQRLPEQQKVFNLPLF
HHCCHHHHHCCCCCC		48.7923954790
432UbiquitinationQRLPEQQKVFNLPLF
HHCCHHHHHCCCCCC		48.7923749301
441PhosphorylationFNLPLFPTTTIGSFP
CCCCCCCCCCCCCCC		29.2723607784
442PhosphorylationNLPLFPTTTIGSFPQ
CCCCCCCCCCCCCCC		19.3623607784
443PhosphorylationLPLFPTTTIGSFPQT
CCCCCCCCCCCCCCC		26.3123607784
446PhosphorylationFPTTTIGSFPQTKDI
CCCCCCCCCCCCCCC		29.8727821475
450PhosphorylationTIGSFPQTKDIRINR
CCCCCCCCCCCEECC		30.8124961812
451AcetylationIGSFPQTKDIRINRN
CCCCCCCCCCEECCC		46.0024489116
451UbiquitinationIGSFPQTKDIRINRN
CCCCCCCCCCEECCC		46.0023749301
462AcetylationINRNKFNKGTISAEE
ECCCCCCCCCCCHHH		61.6424489116
462SuccinylationINRNKFNKGTISAEE
ECCCCCCCCCCCHHH		61.6423954790
472AcetylationISAEEYEKFINSEIE
CCHHHHHHHHCHHHH		51.1224489116
472UbiquitinationISAEEYEKFINSEIE
CCHHHHHHHHCHHHH		51.1223749301
480AcetylationFINSEIEKVIRFQEE
HHCHHHHHHHHHHHH		48.9324489116
548AcetylationRPKAMSVKESVYAQS
CCCCCCHHHHHCCCC		36.6424489116
548UbiquitinationRPKAMSVKESVYAQS
CCCCCCHHHHHCCCC		36.6417644757
558PhosphorylationVYAQSITSKPVKGML
HCCCCCCCCCCCCCC		33.0428152593
559AcetylationYAQSITSKPVKGMLT
CCCCCCCCCCCCCCC		45.2224489116
559SuccinylationYAQSITSKPVKGMLT
CCCCCCCCCCCCCCC		45.2223954790
559UbiquitinationYAQSITSKPVKGMLT
CCCCCCCCCCCCCCC		45.2223749301
562UbiquitinationSITSKPVKGMLTGPI
CCCCCCCCCCCCCCE		47.3222817900
566PhosphorylationKPVKGMLTGPITCLR
CCCCCCCCCCEEEEE		31.8328889911
584AcetylationPRDDVDQKTQAMQLA
CCCCCCHHHHHHHHH		37.8325381059
584UbiquitinationPRDDVDQKTQAMQLA
CCCCCCHHHHHHHHH		37.8324961812
607UbiquitinationDLEAAGIKVIQVDEP
HHHHCCCEEEEECCH		32.1624961812
629PhosphorylationLREGTERSAYYTWAA
CCCCCCCHHHHHHHH		17.8728889911
631PhosphorylationEGTERSAYYTWAAEA
CCCCCHHHHHHHHHH		11.5921440633
675PhosphorylationALDADVVSIEFSKKD
CCCCCEEEEEECCCC		19.0922369663
679PhosphorylationDVVSIEFSKKDDANY
CEEEEEECCCCCCCH		26.4622369663
680AcetylationVVSIEFSKKDDANYI
EEEEEECCCCCCCHH		66.5924489116
691AcetylationANYIAEFKNYPNHIG
CCHHHHHCCCCCCEE		47.2624489116
691UbiquitinationANYIAEFKNYPNHIG
CCHHHHHCCCCCCEE		47.2617644757
693PhosphorylationYIAEFKNYPNHIGLG
HHHHHCCCCCCEEEC		13.1522369663
706PhosphorylationLGLFDIHSPRIPSKD
ECCCCCCCCCCCCHH		19.0622369663
711PhosphorylationIHSPRIPSKDEFIAK
CCCCCCCCHHHHHHH		50.8222369663
712AcetylationHSPRIPSKDEFIAKI
CCCCCCCHHHHHHHH		56.7924489116
712SuccinylationHSPRIPSKDEFIAKI
CCCCCCCHHHHHHHH		56.7923954790
712UbiquitinationHSPRIPSKDEFIAKI
CCCCCCCHHHHHHHH		56.7917644757
718AcetylationSKDEFIAKISTILKS
CHHHHHHHHHHHHHH		32.1624489116
718UbiquitinationSKDEFIAKISTILKS
CHHHHHHHHHHHHHH		32.1617644757
7242-HydroxyisobutyrylationAKISTILKSYPAEKF
HHHHHHHHHCCHHHE		44.06-
724AcetylationAKISTILKSYPAEKF
HHHHHHHHHCCHHHE		44.0624489116
724SuccinylationAKISTILKSYPAEKF
HHHHHHHHHCCHHHE		44.0623954790
724UbiquitinationAKISTILKSYPAEKF
HHHHHHHHHCCHHHE		44.0623749301
730AcetylationLKSYPAEKFWVNPDC
HHHCCHHHEEECCCC		46.7824489116
730UbiquitinationLKSYPAEKFWVNPDC
HHHCCHHHEEECCCC		46.7823749301
740AcetylationVNPDCGLKTRGWEET
ECCCCCCCCCCCHHH		22.8124489116
740UbiquitinationVNPDCGLKTRGWEET
ECCCCCCCCCCCHHH		22.8123749301
750PhosphorylationGWEETRLSLTHMVEA
CCHHHHHHHHHHHHH		28.1219779198
752PhosphorylationEETRLSLTHMVEAAK
HHHHHHHHHHHHHHH		12.4419779198
759AcetylationTHMVEAAKYFREQYK
HHHHHHHHHHHHHHC		52.5524489116
759UbiquitinationTHMVEAAKYFREQYK
HHHHHHHHHHHHHHC		52.5523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of METE_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of METE_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of METE_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IMB1_YEASTKAP95physical
16554755
YBF9_YEASTYBL059Wgenetic
20093466
HAP3_YEASTHAP3genetic
20093466
SLA1_YEASTSLA1genetic
20093466
SIF2_YEASTSIF2genetic
20093466
MBA1_YEASTMBA1genetic
20093466
BEM1_YEASTBEM1genetic
20093466
STE50_YEASTSTE50genetic
20093466
SNT1_YEASTSNT1genetic
20093466
EMI1_YEASTEMI1genetic
20093466
MTC3_YEASTMTC3genetic
20093466
AAKG_YEASTSNF4genetic
20093466
CUE3_YEASTCUE3genetic
20093466
GEP7_YEASTGEP7genetic
20093466
PALF_YEASTRIM8genetic
20093466
KA122_YEASTKAP122genetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
YOR1_YEASTYOR1genetic
20093466
PACC_YEASTRIM101genetic
20093466
FYV4_YEASTFYV4genetic
20093466
HOS4_YEASTHOS4genetic
20093466
YIH7_YEASTYIL077Cgenetic
20093466
YJH0_YEASTYJL070Cgenetic
20093466
PLMT_YEASTOPI3genetic
20093466
URA8_YEASTURA8genetic
20093466
SAC1_YEASTSAC1genetic
20093466
COXM1_YEASTCMC1genetic
20093466
VPS24_YEASTVPS24genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
BAS1_YEASTBAS1genetic
20093466
YPT6_YEASTYPT6genetic
20093466
YMD8_YEASTYMD8genetic
20093466
PALI_YEASTRIM9genetic
20093466
RIM13_YEASTRIM13genetic
20093466
SSO2_YEASTSSO2genetic
20093466
GAS1_YEASTGAS1genetic
20093466
ADE_YEASTAAH1genetic
20093466
ODP2_YEASTLAT1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
VPS27_YEASTVPS27genetic
20093466
ATP23_YEASTATP23genetic
20093466
COQ10_YEASTCOQ10genetic
20093466
DFG16_YEASTDFG16genetic
20093466
GYP1_YEASTGYP1genetic
20093466
PALA_YEASTRIM20genetic
20093466
MEK1_YEASTMEK1genetic
20093466
ALDH6_YEASTALD6genetic
20093466
MTHR2_YEASTMET13genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
MCM1_YEASTMCM1genetic
27708008
TECR_YEASTTSC13genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC20_YEASTCDC20genetic
27708008
SYMC_YEASTMES1genetic
27708008
MED6_YEASTMED6genetic
27708008
ARP4_YEASTARP4genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
SSL1_YEASTSSL1genetic
27708008
CAP_YEASTSRV2genetic
27708008
PROF_YEASTPFY1genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of METE_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-706, AND MASSSPECTROMETRY.

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