COXM1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COXM1_YEAST
• UniProt AC: P36064
• Protein Name: COX assembly mitochondrial protein
• Gene Name: CMC1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 111
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side . Mitochondrion intermembrane space . Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
• Protein Description: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. Binds copper. May be involved in copper trafficking and distribution to mitochondrial COX and SOD1..
• Protein Sequence: MEQNKDPQMISKHSSRLPIWVLSPREEQQARKNLKTETYKKCANFVQAMADCAKANGMKVFPTCDKQRDEMKSCLLFYQTDEKYLDGERDKIVLEKINKLEKLCQKQSSTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	NKDPQMISKHSSRLP CCCHHHHHHCCCCCC	20.97	27017623
14	Phosphorylation	PQMISKHSSRLPIWV HHHHHHCCCCCCEEE	22.38	27017623
96	Acetylation	RDKIVLEKINKLEKL CHHHHHHHHHHHHHH	47.63	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COXM1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COXM1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COXM1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COXM2_YEAST	CMC2	physical	20220131
COA6_YEAST	COA6	genetic	26669719
PSB5_YEAST	PRE2	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
FUMH_YEAST	FUM1	genetic	27708008
CDC27_YEAST	CDC27	genetic	27708008
IPYR_YEAST	IPP1	genetic	27708008
ALG1_YEAST	ALG1	genetic	27708008
POP7_YEAST	POP7	genetic	27708008
MED8_YEAST	MED8	genetic	27708008
MCES_YEAST	ABD1	genetic	27708008
CDC10_YEAST	CDC10	genetic	27708008
UAP1_YEAST	QRI1	genetic	27708008
KIN28_YEAST	KIN28	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
SLU7_YEAST	SLU7	genetic	27708008
TCPA_YEAST	TCP1	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
COG3_YEAST	COG3	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
DUO1_YEAST	DUO1	genetic	27708008
USE1_YEAST	USE1	genetic	27708008
BCD1_YEAST	BCD1	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
TAD2_YEAST	TAD2	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
COFI_YEAST	COF1	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
BET5_YEAST	BET5	genetic	27708008
TRM6_YEAST	GCD10	genetic	27708008
PSA4_YEAST	PRE6	genetic	27708008
NOP8_YEAST	NOP8	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008
APC5_YEAST	APC5	genetic	27708008
GPI2_YEAST	GPI2	genetic	27708008
HPC2_YEAST	HPC2	genetic	27708008
SNF1_YEAST	SNF1	genetic	27708008
CGR1_YEAST	CGR1	genetic	27708008
AAKG_YEAST	SNF4	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
YJY1_YEAST	YJR011C	genetic	27708008
DID2_YEAST	DID2	genetic	27708008
NU133_YEAST	NUP133	genetic	27708008
BAS1_YEAST	BAS1	genetic	27708008
PEX13_YEAST	PEX13	genetic	27708008
ADY4_YEAST	ADY4	genetic	27708008
PFKA2_YEAST	PFK2	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
IRA2_YEAST	IRA2	genetic	27708008
ATG34_YEAST	ATG34	genetic	27708008
PDE2_YEAST	PDE2	genetic	27708008
HSP7F_YEAST	SSE1	genetic	27708008
SPEE_YEAST	SPE3	genetic	27708008
SUE1_YEAST	SUE1	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.