NOP8_YEAST - dbPTM
NOP8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOP8_YEAST
UniProt AC Q08287
Protein Name 60S ribosome subunit biogenesis protein NOP8
Gene Name NOP8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 484
Subcellular Localization Nucleus, nucleolus .
Protein Description Required for 60S ribosomal subunit synthesis. May be involved in assembly reactions occurring within late pre-ribosomal particles..
Protein Sequence MDSVIQKRIFVGNIFHNADDCYSELLDRFGKFGDCQDFQFEKHNHFAFIDIRFNDEADFNKLRKSFNNVKFKGNILKVDEAKPNWESTWAVQHAKDLKEDIILNAKMKKKNWQHYKKMENVAKSWKDHKEVIAGRMREAPRKRSQLRNITFRINVNGSLKVYKCYKTKLWGYERNKELNDLVYKFTNNFWKNGYNHIVDRLDYSRAVKTVRFKNGLKQLTVSKDENVCSGEMDSDENMSEEEKEKNNVILNDLLKDFDFDKPMTLNDSDEELLTEQRKGEEEEEEEEEKEVNAPEYENVNKTKDQSTLPQEKPEERKEQDEGDGQEDNEFIPTFTKEIGQGTISNTETLRNLFNPNEAEPVSQFKLIEDSDNDIDHAKDVDVNQLEEEVSKSSDTLGLTSAPVPHVSRDKDNKNFLFFPHLQSPFLVGQTQLSKVRAPGRETMLSNWDEEFWANRGNWTRDMRRKMKDALKHRKRKQSKSGLLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77AcetylationKFKGNILKVDEAKPN
EEECEEEEECCCCCC		43.7925381059
98AcetylationVQHAKDLKEDIILNA
HHHHHHHCHHHHHHH		64.5724489116
176AcetylationLWGYERNKELNDLVY
CCCCCCCHHHHHHHH		70.5624489116
191AcetylationKFTNNFWKNGYNHIV
HHHHCHHHHCCCHHH		36.0424489116
229PhosphorylationSKDENVCSGEMDSDE
CCCCCCCCCCCCCCC		33.2419779198
234PhosphorylationVCSGEMDSDENMSEE
CCCCCCCCCCCCCHH		45.5820377248
239PhosphorylationMDSDENMSEEEKEKN
CCCCCCCCHHHHHHH		54.1320377248
264PhosphorylationFDFDKPMTLNDSDEE
CCCCCCCCCCCCHHH		30.8224909858
268PhosphorylationKPMTLNDSDEELLTE
CCCCCCCCHHHHHHH		45.9422369663
274PhosphorylationDSDEELLTEQRKGEE
CCHHHHHHHHHCCHH		42.5720377248
289AcetylationEEEEEEEKEVNAPEY
HHHHHHHHHCCCCCC		70.9624489116
306PhosphorylationVNKTKDQSTLPQEKP
CCCCCCCCCCCCCCH		41.8823749301
307PhosphorylationNKTKDQSTLPQEKPE
CCCCCCCCCCCCCHH		36.5023749301
370PhosphorylationQFKLIEDSDNDIDHA
HCEEEECCCCCCCHH		26.0622369663
390PhosphorylationNQLEEEVSKSSDTLG
HHHHHHHHHCCCCCC		30.0519779198
392PhosphorylationLEEEVSKSSDTLGLT
HHHHHHHCCCCCCCC		26.4121440633
393PhosphorylationEEEVSKSSDTLGLTS
HHHHHHCCCCCCCCC		38.0521440633
395PhosphorylationEVSKSSDTLGLTSAP
HHHHCCCCCCCCCCC		25.3621440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOP8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOP8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOP8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NIP7_YEASTNIP7physical
9891085
DBP6_YEASTDBP6genetic
15126390
FBRL_YEASTNOP1physical
16554755
RPF2_YEASTRPF2physical
16554755
RSA3_YEASTRSA3physical
16554755
NOP58_YEASTNOP58physical
16554755
MSN5_YEASTMSN5genetic
19061648
AIR1_YEASTAIR1genetic
19061648
RPB4_YEASTRPB4genetic
19061648
RIT1_YEASTRIT1genetic
19061648
PUF2_YEASTPUF2genetic
19061648
NIP7_YEASTNIP7physical
21747919
RL5_YEASTRPL5physical
21747919
URB1_YEASTURB1physical
25877921
SAC3_YEASTSAC3genetic
27708008
VPS55_YEASTVPS55genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
MAK5_YEASTMAK5genetic
27708008
FBRL_YEASTNOP1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RPN5_YEASTRPN5genetic
27708008
PCF11_YEASTPCF11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
RNA15_YEASTRNA15genetic
27708008
PTI1_YEASTPTI1genetic
27708008
UTP9_YEASTUTP9genetic
27708008
SHQ1_YEASTSHQ1genetic
27708008
CYAA_YEASTCYR1genetic
27708008
ESS1_YEASTESS1genetic
27708008
MAK11_YEASTMAK11genetic
27708008
RRN3_YEASTRRN3genetic
27708008
NOP56_YEASTNOP56genetic
27708008
DBP9_YEASTDBP9genetic
27708008
TAD3_YEASTTAD3genetic
27708008
SEN1_YEASTSEN1genetic
27708008
RNA14_YEASTRNA14genetic
27708008
UTP15_YEASTUTP15genetic
27708008
MED11_YEASTMED11genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DBP6_YEASTDBP6genetic
27708008
SYA_YEASTALA1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
SLA1_YEASTSLA1genetic
27708008
MUM2_YEASTMUM2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
PYC2_YEASTPYC2genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
PAT1_YEASTPAT1genetic
27708008
MCH1_YEASTMCH1genetic
27708008
RL41A_YEASTRPL41Agenetic
27708008
RL41B_YEASTRPL41Agenetic
27708008
YD056_YEASTYDR056Cgenetic
27708008
ARX1_YEASTARX1genetic
27708008
RT103_YEASTRTT103genetic
27708008
IPK1_YEASTIPK1genetic
27708008
MSN5_YEASTMSN5genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
RTR1_YEASTRTR1genetic
27708008
SWP82_YEASTSWP82genetic
27708008
UBP6_YEASTUBP6genetic
27708008
KCC1_YEASTCMK1genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
DBP3_YEASTDBP3genetic
27708008
MMS2_YEASTMMS2genetic
27708008
MON1_YEASTMON1genetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
YG5X_YEASTYGR283Cgenetic
27708008
MALX3_YEASTIMA1genetic
27708008
PIH1_YEASTPIH1genetic
27708008
SSF1_YEASTSSF1genetic
27708008
ARP1_YEASTARP1genetic
27708008
STB5_YEASTSTB5genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
LSM1_YEASTLSM1genetic
27708008
MDM35_YEASTMDM35genetic
27708008
CTK1_YEASTCTK1genetic
27708008
POC2_YEASTADD66genetic
27708008
FMP46_YEASTFMP46genetic
27708008
SRP40_YEASTSRP40genetic
27708008
UPS1_YEASTUPS1genetic
27708008
RSA3_YEASTRSA3genetic
27708008
VIP1_YEASTVIP1genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
YM91_YEASTYMR310Cgenetic
27708008
DOM34_YEASTDOM34genetic
27708008
RNH2A_YEASTRNH201genetic
27708008
EAF7_YEASTEAF7genetic
27708008
ATP23_YEASTATP23genetic
27708008
ALG12_YEASTALG12genetic
27708008
YN92_YEASTYNR063Wgenetic
27708008
ATG29_YEASTATG29genetic
27708008
PPQ1_YEASTPPQ1genetic
27708008
ROX1_YEASTROX1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
YP078_YEASTYPR078Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOP8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268 AND SER-370, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268 AND SER-370, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-274 AND SER-370, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268 AND SER-370, ANDMASS SPECTROMETRY.

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