| UniProt ID | PCF11_YEAST | |
|---|---|---|
| UniProt AC | P39081 | |
| Protein Name | Protein PCF11 | |
| Gene Name | PCF11 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 626 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex. Independently involved in RNA polymerase II transcript termination. Binds RNA. Seems to bridge RNA polymerase II and the native transcript and may be involved in dismantling the RNA polymerase II elongation complex.. | |
| Protein Sequence | MDHDTEVIVKDFNSILEELTFNSRPIITTLTKLAEENISCAQYFVDAIESRIEKCMPKQKLYAFYALDSICKNVGSPYTIYFSRNLFNLYKRTYLLVDNTTRTKLINMFKLWLNPNDTGLPLFEGSALEKIEQFLIKASALHQKNLQAMLPTPTVPLLLRDIDKLTCLTSERLKNQPNDEKLKMKLLVLSQLKQELKREKLTLNALKQVQMQLRQVFSQDQQVLQERMRYHELQQQQQQQQQQQQQQQQQQQQYHETKDMVGSYTQNSNSAIPLFGNNSDTTNQQNSLSSSLFGNISGVESFQEIEKKKSLNKINNLYASLKAEGLIYTPPKESIVTLYKKLNGHSNYSLDSHEKQLMKNLPKIPLLNDILSDCKAYFATVNIDVLNNPSLQLSEQTLLQENPIVQNNLIHLLYRSKPNKCSVCGKRFGNSESEKLLQNEHLDWHFRINTRIKGSQNTANTGISNSNLNTTTTRKNIQSRNWYLSDSQWAAFKDDEITSTKHKNDYTDPHANKNIDKSALNIHADENDEGSVDNTLGSDRSNELEIRGKYVVVPETSQDMAFKCPICKETVTGVYDEESGEWVWKNTIEVNGKYFHSTCYHETSQNSSKSNSGKVGLDDLKKLVTK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MDHDTEVIVKDF ---CCCCCEEHHCCH | 28.82 | 30377154 | |
| 104 | Acetylation | VDNTTRTKLINMFKL ECCCCCHHHHHHEEH | 44.04 | 24489116 | |
| 313 | Acetylation | EKKKSLNKINNLYAS HHHHCHHHHHHHHHH | 52.70 | 22865919 | |
| 464 | Phosphorylation | NTANTGISNSNLNTT CCCCCCCCCCCCCCC | 35.23 | 23749301 | |
| 518 | Phosphorylation | ANKNIDKSALNIHAD CCCCCCHHHEECCCC | 33.95 | 24961812 | |
| 531 | Phosphorylation | ADENDEGSVDNTLGS CCCCCCCCCCCCCCC | 25.01 | 24961812 | |
| 535 | Phosphorylation | DEGSVDNTLGSDRSN CCCCCCCCCCCCCCC | 28.21 | 24961812 | |
| 538 | Phosphorylation | SVDNTLGSDRSNELE CCCCCCCCCCCCCEE | 32.72 | 24961812 | |
| 541 | Phosphorylation | NTLGSDRSNELEIRG CCCCCCCCCCEEEEC | 39.38 | 24961812 | |
| 572 | Phosphorylation | PICKETVTGVYDEES CCCCCEECEEEECCC | 28.49 | 27017623 | |
| 575 | Phosphorylation | KETVTGVYDEESGEW CCEECEEEECCCCCE | 20.98 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCF11_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCF11_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCF11_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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