| UniProt ID | SET3_YEAST | |
|---|---|---|
| UniProt AC | P36124 | |
| Protein Name | SET domain-containing protein 3 | |
| Gene Name | SET3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 751 | |
| Subcellular Localization | ||
| Protein Description | Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.. | |
| Protein Sequence | MSVPNSKEQSLLDDASTLLLFSKGKKRAEEASKIGSKTDTIEHDESHEREKKGAIEMAAAALATASTVSLPLKKATEQSAAEAATSTAAKEETENQPQKQPQWPVPDSYIVDPDAGIITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAPDDYLCNSCDPREVDINLARKIQQERINVKTVEPSSSNNSASNKNNGRDRASSTTISDVGDSFSTDQDNTNHRDKRRKRNPSNNSIDSKNESASVNSSDGLTSMPKKKEHFLSAKDAYGAIYLPLKDNVFKSDLIEPFLNKHMDDNWVIQYPHKTFKSVSIEVKPYADIAYSRTYPGFTKLGVYLKKDCIKGDFIQEILGELDFYKNYLTDPRNHYRIWGTAKRRVIFHSHWPIYIDARLSGNSTRYLRRSCQPNVELVTIKLQDTDNRNDKSSGRKSSRIKFVLRALRDISEDEELYIKWQWDSKHPILKLIKGMTIDSLDDLERYGLINSVETILSNGECGCGNNSKDCYLLKVKRYAQSLYKSVKSRGKMNNRYKLNEILNQYNCKKRREPPILHRLEEKAQNTIERAPILLNNFYRQKFLNRNNGPKIPQKNTIDSTNNPDDIAKPFKFALFAQHSSNISVPKKNETSEKPLIITKSTDYDESHITNIEELPIPVLLPINKTSRQTANDVEESQSKNEHKLSRTPSLSNFNKELSKEAQHSQAKTKEIMTEASVNSRRESTPESIMHLSDFSSSQLHSKKKLSFADYRKKLLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | VPNSKEQSLLDDAST CCCHHHHHHHHHHHH | 31.80 | 30377154 | |
| 23 | Acetylation | STLLLFSKGKKRAEE HHHHHHHHHHHHHHH | 68.37 | 24489116 | |
| 32 | Phosphorylation | KKRAEEASKIGSKTD HHHHHHHHHHCCCCC | 28.25 | 21551504 | |
| 36 | Phosphorylation | EEASKIGSKTDTIEH HHHHHHCCCCCCCCC | 35.54 | 21551504 | |
| 76 | Phosphorylation | SLPLKKATEQSAAEA CCCCHHHHHHHHHHH | 43.36 | 27017623 | |
| 79 | Phosphorylation | LKKATEQSAAEAATS CHHHHHHHHHHHHHH | 24.18 | 21551504 | |
| 85 | Phosphorylation | QSAAEAATSTAAKEE HHHHHHHHHHHHHHH | 33.39 | 21551504 | |
| 86 | Phosphorylation | SAAEAATSTAAKEET HHHHHHHHHHHHHHH | 16.01 | 21551504 | |
| 87 | Phosphorylation | AAEAATSTAAKEETE HHHHHHHHHHHHHHC | 26.70 | 27017623 | |
| 93 | Phosphorylation | STAAKEETENQPQKQ HHHHHHHHCCCCCCC | 41.13 | 21551504 | |
| 190 | Phosphorylation | VKTVEPSSSNNSASN CEECCCCCCCCCCCC | 48.04 | 30377154 | |
| 191 | Phosphorylation | KTVEPSSSNNSASNK EECCCCCCCCCCCCC | 44.35 | 30377154 | |
| 194 | Phosphorylation | EPSSSNNSASNKNNG CCCCCCCCCCCCCCC | 37.01 | 28889911 | |
| 206 | Phosphorylation | NNGRDRASSTTISDV CCCCCCCCCCCHHHC | 29.16 | 22369663 | |
| 207 | Phosphorylation | NGRDRASSTTISDVG CCCCCCCCCCHHHCC | 28.69 | 22369663 | |
| 208 | Phosphorylation | GRDRASSTTISDVGD CCCCCCCCCHHHCCC | 26.17 | 22369663 | |
| 209 | Phosphorylation | RDRASSTTISDVGDS CCCCCCCCHHHCCCC | 22.04 | 22369663 | |
| 211 | Phosphorylation | RASSTTISDVGDSFS CCCCCCHHHCCCCCC | 24.93 | 22369663 | |
| 216 | Phosphorylation | TISDVGDSFSTDQDN CHHHCCCCCCCCCCC | 18.37 | 22369663 | |
| 218 | Phosphorylation | SDVGDSFSTDQDNTN HHCCCCCCCCCCCCC | 34.72 | 22369663 | |
| 219 | Phosphorylation | DVGDSFSTDQDNTNH HCCCCCCCCCCCCCH | 35.35 | 22369663 | |
| 236 | Phosphorylation | KRRKRNPSNNSIDSK HHHHCCCCCCCCCCC | 52.79 | 21440633 | |
| 239 | Phosphorylation | KRNPSNNSIDSKNES HCCCCCCCCCCCCCC | 31.83 | 21440633 | |
| 243 | Acetylation | SNNSIDSKNESASVN CCCCCCCCCCCCCCC | 62.07 | 24489116 | |
| 246 | Phosphorylation | SIDSKNESASVNSSD CCCCCCCCCCCCCCC | 34.93 | 28889911 | |
| 251 | Phosphorylation | NESASVNSSDGLTSM CCCCCCCCCCCCCCC | 27.87 | 27214570 | |
| 252 | Phosphorylation | ESASVNSSDGLTSMP CCCCCCCCCCCCCCC | 30.41 | 25752575 | |
| 312 | Phosphorylation | YPHKTFKSVSIEVKP CCCCEECEEEEEEEE | 19.53 | 21440633 | |
| 314 | Phosphorylation | HKTFKSVSIEVKPYA CCEECEEEEEEEECC | 21.81 | 21440633 | |
| 474 | Phosphorylation | IKGMTIDSLDDLERY HCCCCCCCHHHHHHH | 29.82 | 28152593 | |
| 543 | Acetylation | ILNQYNCKKRREPPI HHHHCCCCCCCCCCH | 45.75 | 25381059 | |
| 557 | Ubiquitination | ILHRLEEKAQNTIER HHHHHHHHHHHHHHH | 45.99 | 23749301 | |
| 614 | Phosphorylation | FALFAQHSSNISVPK HHHHEECCCCCCCCC | 17.01 | 30377154 | |
| 615 | Phosphorylation | ALFAQHSSNISVPKK HHHEECCCCCCCCCC | 35.74 | 30377154 | |
| 635 | Phosphorylation | KPLIITKSTDYDESH CCEEEEECCCCCHHH | 20.19 | 30377154 | |
| 680 | Phosphorylation | SKNEHKLSRTPSLSN HHCCHHHCCCCCHHH | 38.62 | 20377248 | |
| 682 | Phosphorylation | NEHKLSRTPSLSNFN CCHHHCCCCCHHHHC | 17.54 | 20377248 | |
| 684 | Phosphorylation | HKLSRTPSLSNFNKE HHHCCCCCHHHHCHH | 43.76 | 22369663 | |
| 686 | Phosphorylation | LSRTPSLSNFNKELS HCCCCCHHHHCHHHH | 43.65 | 21440633 | |
| 708 | Phosphorylation | AKTKEIMTEASVNSR HHHHHHHHHHHHHCC | 33.78 | 24961812 | |
| 711 | Phosphorylation | KEIMTEASVNSRRES HHHHHHHHHHCCCCC | 18.66 | 24961812 | |
| 714 | Phosphorylation | MTEASVNSRRESTPE HHHHHHHCCCCCCHH | 30.47 | 24961812 | |
| 718 | Phosphorylation | SVNSRRESTPESIMH HHHCCCCCCHHHHHH | 47.66 | 22369663 | |
| 719 | Phosphorylation | VNSRRESTPESIMHL HHCCCCCCHHHHHHH | 26.73 | 22369663 | |
| 722 | Phosphorylation | RRESTPESIMHLSDF CCCCCHHHHHHHHHC | 26.81 | 22369663 | |
| 727 | Phosphorylation | PESIMHLSDFSSSQL HHHHHHHHHCCHHHC | 23.18 | 19779198 | |
| 730 | Phosphorylation | IMHLSDFSSSQLHSK HHHHHHCCHHHCCCC | 33.79 | 19779198 | |
| 731 | Phosphorylation | MHLSDFSSSQLHSKK HHHHHCCHHHCCCCC | 23.30 | 21440633 | |
| 732 | Phosphorylation | HLSDFSSSQLHSKKK HHHHCCHHHCCCCCC | 35.25 | 28889911 | |
| 738 | Acetylation | SSQLHSKKKLSFADY HHHCCCCCCCCHHHH | 63.06 | 24489116 | |
| 741 | Phosphorylation | LHSKKKLSFADYRKK CCCCCCCCHHHHHHH | 27.54 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SET3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SET3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SET3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-252; SER-684AND SER-741, AND MASS SPECTROMETRY. | |
