TYE7_YEAST - dbPTM
TYE7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TYE7_YEAST
UniProt AC P33122
Protein Name Serine-rich protein TYE7
Gene Name TYE7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 291
Subcellular Localization Nucleus .
Protein Description Transcriptional activator of glycolytic gene expression, such as enolase genes (ENO1 and ENO2), glyceraldehyde-3-phosphate dehydrogenase gene (TDH), phosphoglycerate kinase (PGK1), phosphoglycerate mutase (PGM1), pyruvate kinase (PYK1) and triosephosphate isomerase (TPI1) genes. Binds DNA on E-box motifs: 5'-CANNTG-3'..
Protein Sequence MNSILDRNVRSSETTLIKPESEFDNWLSDENDGASHINVNKDSSSVLSASSSTWFEPLENIISSASSSSIGSPIEDQFISSNNEESALFPTDQFFSNPSSYSHSPEVSSSIKREEDDNALSLADFEPASLQLMPNMINTDNNDDSTPLKNEIELNDSFIKTNLDAKETKKRAPRKRLTPFQKQAHNKIEKRYRININTKIARLQQIIPWVASEQTAFEVGDSVKKQDEDGAETAATTPLPSAAATSTKLNKSMILEKAVDYILYLQNNERLYEMEVQRLKSEIDTLKQDQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MNSILDRNVR
-----CCCCHHHCCC		24.1919823750
11PhosphorylationILDRNVRSSETTLIK
CHHHCCCCCCCEEEC		28.3922369663
12PhosphorylationLDRNVRSSETTLIKP
HHHCCCCCCCEEECC		28.5322369663
14PhosphorylationRNVRSSETTLIKPES
HCCCCCCCEEECCHH		28.9322369663
15PhosphorylationNVRSSETTLIKPESE
CCCCCCCEEECCHHH		23.5722369663
21PhosphorylationTTLIKPESEFDNWLS
CEEECCHHHHCCCCC		52.6822369663
28PhosphorylationSEFDNWLSDENDGAS
HHHCCCCCCCCCCCC		34.2022369663
35PhosphorylationSDENDGASHINVNKD
CCCCCCCCCEECCCC		30.3522369663
104PhosphorylationNPSSYSHSPEVSSSI
CCCCCCCCCCHHHHC		19.4728889911
157PhosphorylationNEIELNDSFIKTNLD
CEEECCHHHHHHCCC		28.0022369663
178PhosphorylationRAPRKRLTPFQKQAH
HCCHHCCCHHHHHHH		26.5321440633
224UbiquitinationFEVGDSVKKQDEDGA
EECCCCCCCCCCCCC		48.9817644757
225UbiquitinationEVGDSVKKQDEDGAE
ECCCCCCCCCCCCCC		61.9117644757
233PhosphorylationQDEDGAETAATTPLP
CCCCCCCCCCCCCCC		22.5122369663
236PhosphorylationDGAETAATTPLPSAA
CCCCCCCCCCCCCHH		26.8725521595
237PhosphorylationGAETAATTPLPSAAA
CCCCCCCCCCCCHHH		20.3622369663
241PhosphorylationAATTPLPSAAATSTK
CCCCCCCCHHHCCCC		37.9222369663
245PhosphorylationPLPSAAATSTKLNKS
CCCCHHHCCCCCCHH		32.0022369663
246PhosphorylationLPSAAATSTKLNKSM
CCCHHHCCCCCCHHH		20.8622369663
247PhosphorylationPSAAATSTKLNKSMI
CCHHHCCCCCCHHHH		34.8922369663
248UbiquitinationSAAATSTKLNKSMIL
CHHHCCCCCCHHHHH		50.2417644757
257UbiquitinationNKSMILEKAVDYILY
CHHHHHHHHHHHHHH		50.7117644757
280UbiquitinationEMEVQRLKSEIDTLK
HHHHHHHHHHHHHHH		48.5117644757
287UbiquitinationKSEIDTLKQDQK---
HHHHHHHHHHCC---		54.6517644757
291UbiquitinationDTLKQDQK-------
HHHHHHCC-------		71.2717644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TYE7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TYE7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TYE7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOS2_YEASTHOS2genetic
20959818
IES4_YEASTIES4genetic
20959818
SUB1_YEASTSUB1genetic
20959818
YPT6_YEASTYPT6genetic
20959818
GCR2_YEASTGCR2genetic
20959818
FUS3_YEASTFUS3genetic
21127252
BUB1_YEASTBUB1genetic
21127252
MRE11_YEASTMRE11genetic
21127252
INO2_YEASTINO2genetic
21127252
SOK2_YEASTSOK2genetic
21127252
ADA2_YEASTADA2genetic
21127252
CLA4_YEASTCLA4genetic
21127252
GCR2_YEASTGCR2genetic
21127252
CBF1_YEASTCBF1genetic
21127252
ARP8_YEASTARP8genetic
21127252
NU133_YEASTNUP133genetic
21127252
HPH2_YEASTFRT2physical
22875988
PRP45_YEASTPRP45physical
22875988
AP2A_YEASTAPL3physical
22875988
KIP1_YEASTKIP1physical
22875988
RXT2_YEASTRXT2physical
22875988
ATG14_YEASTATG14physical
22875988
SP381_YEASTSPP381physical
22875988
ISW1_YEASTISW1physical
22875988
MRC1_YEASTMRC1physical
22875988
RV161_YEASTRVS161physical
22875988
NOP14_YEASTNOP14physical
22875988
ADY3_YEASTADY3physical
22875988
SPC19_YEASTSPC19physical
22875988
GLU2B_YEASTGTB1physical
22875988
IVY1_YEASTIVY1physical
22875988
NACB2_YEASTBTT1physical
22875988
YAP6_YEASTYAP6physical
22875988
HDA2_YEASTHDA2physical
22875988
SUM1_YEASTSUM1physical
22875988
SP110_YEASTSPC110physical
22875988
SHE9_YEASTSHE9physical
22875988
RRP17_YEASTRRP17physical
22875988
LRS4_YEASTLRS4physical
22875988
TFB3_YEASTTFB3physical
22875988
PSP1_YEASTPSP1physical
22875988
SPC25_YEASTSPC25physical
22875988
TSC11_YEASTTSC11physical
22875988
VFA1_YEASTVFA1physical
22875988
GCN20_YEASTGCN20physical
22875988
IRC5_YEASTIRC5physical
22875988
ERP6_YEASTERP6physical
22875988
MPS2_YEASTMPS2physical
22875988
MAD1_YEASTMAD1physical
22875988
ITC1_YEASTITC1physical
22875988
ATG1_YEASTATG1physical
22875988
VAM7_YEASTVAM7physical
22875988
RTF1_YEASTRTF1physical
22875988
SNU71_YEASTSNU71physical
22875988
COG2_YEASTCOG2physical
22875988
YG3A_YEASTYGR130Cphysical
22875988
CCM1_YEASTCCM1physical
22875988
KEL2_YEASTKEL2physical
22875988
MGA1_YEASTMGA1physical
22875988
TBP7_YEASTYTA7physical
22875988
HSE1_YEASTHSE1physical
22875988
MYO1_YEASTMYO1physical
22875988
RPN1_YEASTRPN1physical
22875988
BZZ1_YEASTBZZ1physical
22875988
KC11_YEASTYCK1physical
22875988
TDA11_YEASTTDA11physical
22875988
MPS3_YEASTMPS3physical
22875988
VPS53_YEASTVPS53physical
22875988
SNX4_YEASTSNX4physical
22875988
SET2_YEASTSET2physical
22875988
SWI3_YEASTSWI3physical
22875988
SWE1_YEASTSWE1physical
22875988
MPP10_YEASTMPP10physical
22875988
EAF6_YEASTEAF6physical
22875988
ACF4_YEASTACF4physical
22875988
ATP7_YEASTATP7physical
22875988
YKF0_YEASTYKL050Cphysical
22875988
LHS1_YEASTLHS1physical
22875988
SMY1_YEASTSMY1physical
22875988
VATC_YEASTVMA5physical
22875988
HSK3_YEASTHSK3physical
22875988
RT22_YEASTRSM22physical
22875988
EBP2_YEASTEBP2physical
22875988
CASP_YEASTCOY1physical
22875988
NTR2_YEASTNTR2physical
22875988
DID2_YEASTDID2physical
22875988
DYHC_YEASTDYN1physical
22875988
SNF7_YEASTSNF7physical
22875988
YL031_YEASTYLR031Wphysical
22875988
BOS1_YEASTBOS1physical
22875988
SEN2_YEASTSEN2physical
22875988
MDN1_YEASTMDN1physical
22875988
VTA1_YEASTVTA1physical
22875988
ENT2_YEASTENT2physical
22875988
HSP7Q_YEASTSSQ1physical
22875988
NBP1_YEASTNBP1physical
22875988
PFD5_YEASTGIM5physical
22875988
NU188_YEASTNUP188physical
22875988
FAR3_YEASTFAR3physical
22875988
VPS20_YEASTVPS20physical
22875988
SSO2_YEASTSSO2physical
22875988
END3_YEASTEND3physical
22875988
CBK1_YEASTCBK1physical
22875988
MED15_YEASTGAL11physical
22875988
NUF2_YEASTNUF2physical
22875988
MSH2_YEASTMSH2physical
22875988
VAM3_YEASTVAM3physical
22875988
BFR1_YEASTBFR1physical
22875988
SNF2_YEASTSNF2physical
22875988
RPA1_YEASTRPA190physical
22875988
REV1_YEASTREV1physical
22875988
CTF19_YEASTCTF19physical
22875988
ULP1_YEASTULP1physical
22875988
SKS1_YEASTSKS1physical
22875988
MEI5_YEASTMEI5physical
22875988
SPC29_YEASTSPC29physical
22875988
SPP1_YEASTSPP1physical
22875988
NIP80_YEASTNIP100physical
22875988
YP216_YEASTYPL216Wphysical
22875988
SSO1_YEASTSSO1physical
22875988
BBP1_YEASTBBP1physical
22875988
MCM16_YEASTMCM16physical
22875988
ATG11_YEASTATG11physical
22875988
YP117_YEASTYPR117Wphysical
22875988
YP174_YEASTYPR174Cphysical
22875988
YAP8_YEASTARR1physical
22875988
DAL81_YEASTDAL81genetic
27708008
YL225_YEASTYLR225Cgenetic
27708008
INO2_YEASTINO2genetic
27708008
RIM15_YEASTRIM15genetic
27708008
G3P3_YEASTTDH3genetic
27708008
SMI1_YEASTSMI1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
ICE2_YEASTICE2genetic
27708008
BNA3_YEASTBNA3genetic
27708008
LSM1_YEASTLSM1genetic
27708008
RPA34_YEASTRPA34genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
CBF1_YEASTCBF1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
NAP1_YEASTNAP1genetic
27708008
BRE2_YEASTBRE2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
COA4_YEASTCOA4genetic
27708008
ARV1_YEASTARV1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
SOK2_YEASTSOK2genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
IRA2_YEASTIRA2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TYE7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; THR-233 ANDTHR-237, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-233 AND THR-237, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, AND MASSSPECTROMETRY.

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