YP174_YEAST - dbPTM
YP174_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YP174_YEAST
UniProt AC Q06616
Protein Name Nuclear envelope protein YPR174C
Gene Name YPR174C
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 221
Subcellular Localization Nucleus membrane
Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein Description Specialized component of the nuclear membrane that may be involved in the connection of the spindle pole body (SPB) to the nuclear envelope..
Protein Sequence MGIQEKTLGIRKERKLVVVPRERNHVRHASQRTRSKNYKNISKKRAQQHAFGFNIAKTLAKIQAFVWGSPADEEEESVVPLSKNSQDCVPLQWQAKFAQLRQQLHSTQKELQFVKEKCHLLQSVLDDANIDQRYLESRRDMKNIERDNLKPTENLPPSPVRAVNPLVTSSPIHMSPLQSRQRPVSSLQPPKGPNFYAKYPKLPQTNILRESPTEDSVPHAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
69PhosphorylationIQAFVWGSPADEEEE
HHHHHCCCCCCCCHH		10.9527017623
77PhosphorylationPADEEEESVVPLSKN
CCCCCHHCCCCCCCC		31.5227017623
85PhosphorylationVVPLSKNSQDCVPLQ
CCCCCCCCCCCCCHH		31.0021440633
152PhosphorylationERDNLKPTENLPPSP
CCCCCCCCCCCCCCC		35.6028132839
158PhosphorylationPTENLPPSPVRAVNP
CCCCCCCCCCCCCCC		33.8027738172
168PhosphorylationRAVNPLVTSSPIHMS
CCCCCCCCCCCCCCC		31.0422369663
169PhosphorylationAVNPLVTSSPIHMSP
CCCCCCCCCCCCCCC		27.0022369663
170PhosphorylationVNPLVTSSPIHMSPL
CCCCCCCCCCCCCCC		20.6422369663
175PhosphorylationTSSPIHMSPLQSRQR
CCCCCCCCCCCCCCC		14.3222369663
179PhosphorylationIHMSPLQSRQRPVSS
CCCCCCCCCCCCHHH		37.7622369663
198AcetylationKGPNFYAKYPKLPQT
CCCCCHHCCCCCCCC		51.1922865919
205PhosphorylationKYPKLPQTNILRESP
CCCCCCCCCCCCCCC		23.4519823750
211PhosphorylationQTNILRESPTEDSVP
CCCCCCCCCCCCCCC		30.5919823750
213PhosphorylationNILRESPTEDSVPHA
CCCCCCCCCCCCCCC		62.8025752575
216PhosphorylationRESPTEDSVPHAE--
CCCCCCCCCCCCC--		31.1727214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YP174_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YP174_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YP174_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IMB4_YEASTKAP123physical
16429126
PYR1_YEASTURA2physical
16429126
RNA15_YEASTRNA15genetic
19061648
NU120_YEASTNUP120genetic
19061648
LSM7_YEASTLSM7genetic
19061648
ELP5_YEASTIKI1genetic
19061648
MPS3_YEASTMPS3physical
18719252
TVP15_YEASTTVP15physical
18719252
PRM8_YEASTPRM8physical
18719252
PSS_YEASTCHO1physical
18719252
CDC5_YEASTCDC5physical
18719252
MGA2_YEASTMGA2physical
18719252
SLX8_YEASTSLX8genetic
27708008
STB5_YEASTSTB5genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RU2A_YEASTLEA1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
APC11_YEASTAPC11genetic
27708008
PRP9_YEASTPRP9genetic
27708008
KIN28_YEASTKIN28genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
CDC12_YEASTCDC12genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NTR2_YEASTNTR2genetic
27708008
TRM6_YEASTGCD10genetic
27708008
TYSY_YEASTCDC21genetic
27708008
NAB3_YEASTNAB3genetic
27708008
MGR1_YEASTMGR1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
CRD1_YEASTCRD1genetic
27708008
OST4_YEASTOST4genetic
27708008
DHAS_YEASTHOM2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
H2A1_YEASTHTA1genetic
27708008
DOT1_YEASTDOT1genetic
27708008
PUF6_YEASTPUF6genetic
27708008
CUE3_YEASTCUE3genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
ASK10_YEASTASK10genetic
27708008
TNA1_YEASTTNA1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
ELM1_YEASTELM1genetic
27708008
FEN1_YEASTRAD27genetic
27708008
POC4_YEASTPOC4genetic
27708008
ARH_HUMANLDLRAP1physical
27107014
FATE1_HUMANFATE1physical
27107014
KASH5_HUMANCCDC155physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YP174_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158; SER-170; SER-175AND SER-211, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158 AND SER-175, ANDMASS SPECTROMETRY.

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