dbPTM

PYR1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYR1_YEAST
UniProt AC	P07259
Protein Name	Protein URA2
Gene Name	URA2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	2214
Subcellular Localization	Cytoplasm .
Protein Description	This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)..
Protein Sequence	MATIAPTAPITPPMESTGDRLVTLELKDGTVLQGYSFGAEKSVAGELVFQTGMVGYPESVTDPSYEGQILVITYPLVGNYGVPDMHLRDELVEELPRYFESNRIHIAGLVISHYTDEYSHYLAKSSLGKWLQNEGIPAVYGVDTRSLTKHLRDAGSMLGRLSLEKSGSDRTISRSSSWRSAFDVPEWVDPNVQNLVSKVSINEPKLYVPPADNKHIELQTGPDGKVLRILAIDVGMKYNQIRCFIKRGVELKVVPWNYDFTKEDYDGLFISNGPGDPSVLDDLSQRLSNVLEAKKTPVFGICLGHQLIARAAGASTLKLKFGNRGHNIPCTSTISGRCYITSQNHGFAVDVDTLTSGWKPLFVNANDDSNEGIYHSELPYFSVQFHPESTPGPRDTEFLFDVFIQAVKEFKYTQVLKPIAFPGGLLEDNVKAHPRIEAKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFVPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTEDRELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKELVDLCNVAFSSSPQVLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEVKNSVTKSTCACFEPSLDYCVVKMPRWDLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKAIRSTEYANLGFNETDLDIDIDYELNNPTDMRVFAIANAFAKKGYSVDKVWEMTRIDKWFLNKLHDLVQFAEKISSFGTKEELPSLVLRQAKQLGFDDRQIARFLDSNEVAIRRLRKEYGITPFVKQIDTVAAEFPAYTNYLYMTYNADSHDLSFDDHGVMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETINLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRMLDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQAVEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDLAPETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNLIELATKAIMGLPLTPYPVEKLPDDYVAVKVPQFSFPRLAGADPVLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKKNILLSIGSYKEKQELLSSVQKLYNMGYKLFATSGTADFLSEHGIAVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLPSANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAISRNITLDVSERDAQTSHRTITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLKAANSVSQDSSYTDFSFTIAGTAHNAHSVTQSASKVTALFLPLRELKNKITAVAELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAKDPRVTCDVNIYSLFIAQDDYPEAVFLPTKEDQEFFWNNLDSIDAFSVGALPVALANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDLDYSFRRNKRWSPFNKDMNGGIERVVYNGETLVLSGELVSPGAKGKCIVNPSPASITASAELQSTSAKRRFSITEEAIADNLDAAEDAIPEQPLEQKLMSSRPPRELVAPGAIQNLIRSNNPFRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFEPSTRTCSSFIAAMERLGGRIVNVNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSPVPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQVRINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEYARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALLAMVMGVDM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATIAPTAP ------CCCCCCCCC	21.01	22814378
3	Phosphorylation	-----MATIAPTAPI -----CCCCCCCCCC	29.54	28889911
7	Phosphorylation	-MATIAPTAPITPPM -CCCCCCCCCCCCCC	35.72	28132839
11	Phosphorylation	IAPTAPITPPMESTG CCCCCCCCCCCCCCC	21.93	28132839
16	Phosphorylation	PITPPMESTGDRLVT CCCCCCCCCCCCEEE	31.29	30377154
17	Phosphorylation	ITPPMESTGDRLVTL CCCCCCCCCCCEEEE	29.78	30377154
27	Ubiquitination	RLVTLELKDGTVLQG CEEEEEECCCCEEEE	44.74	17644757
41	Ubiquitination	GYSFGAEKSVAGELV EEECCCCCCCCCEEE	50.09	17644757
129	Acetylation	LAKSSLGKWLQNEGI HHHHHHHHHHHHCCC	50.45	24489116
129	Ubiquitination	LAKSSLGKWLQNEGI HHHHHHHHHHHHCCC	50.45	17644757
149	Ubiquitination	VDTRSLTKHLRDAGS CCHHHHHHHHHHHHH	46.03	15699485
165	2-Hydroxyisobutyrylation	LGRLSLEKSGSDRTI HHHHCCCCCCCCCCC	66.46	-
165	Ubiquitination	LGRLSLEKSGSDRTI HHHHCCCCCCCCCCC	66.46	22817900
171	Phosphorylation	EKSGSDRTISRSSSW CCCCCCCCCCCCCCH	28.44	21440633
175	Phosphorylation	SDRTISRSSSWRSAF CCCCCCCCCCHHHCC	23.18	21440633
198	Ubiquitination	NVQNLVSKVSINEPK CHHHHHHHCCCCCCC	32.30	17644757
205	Acetylation	KVSINEPKLYVPPAD HCCCCCCCEECCCCC	46.39	24489116
205	Succinylation	KVSINEPKLYVPPAD HCCCCCCCEECCCCC	46.39	23954790
214	Acetylation	YVPPADNKHIELQTG ECCCCCCCCEEEEEC	46.65	24489116
214	Ubiquitination	YVPPADNKHIELQTG ECCCCCCCCEEEEEC	46.65	23749301
225	Acetylation	LQTGPDGKVLRILAI EEECCCCCEEEEEEE	45.54	24489116
225	Ubiquitination	LQTGPDGKVLRILAI EEECCCCCEEEEEEE	45.54	22817900
252	Ubiquitination	IKRGVELKVVPWNYD HHCCCEEEEECCCCC	27.90	17644757
262	Ubiquitination	PWNYDFTKEDYDGLF CCCCCCCHHHCCCEE	48.89	17644757
294	Succinylation	LSNVLEAKKTPVFGI HHHHHHHCCCCCEEE	48.05	23954790
294	Ubiquitination	LSNVLEAKKTPVFGI HHHHHHHCCCCCEEE	48.05	17644757
295	Ubiquitination	SNVLEAKKTPVFGIC HHHHHHCCCCCEEEE	66.17	17644757
408	Ubiquitination	DVFIQAVKEFKYTQV HHHHHHHHHCCCCEE	61.52	17644757
411	Ubiquitination	IQAVKEFKYTQVLKP HHHHHHCCCCEECCC	48.78	17644757
417	Acetylation	FKYTQVLKPIAFPGG CCCCEECCCEECCCC	35.21	24489116
417	Succinylation	FKYTQVLKPIAFPGG CCCCEECCCEECCCC	35.21	23954790
417	Ubiquitination	FKYTQVLKPIAFPGG CCCCEECCCEECCCC	35.21	17644757
431	Acetylation	GLLEDNVKAHPRIEA CCCCCCCCCCCCCCC	47.43	24489116
431	Ubiquitination	GLLEDNVKAHPRIEA CCCCCCCCCCCCCCC	47.43	17644757
466	Ubiquitination	YSGSQAIKALKEEGI CCHHHHHHHHHHCCC	51.16	17644757
469	Ubiquitination	SQAIKALKEEGIYTI HHHHHHHHHCCCEEE	59.59	17644757
489	Ubiquitination	IATIQTSKGLADKVY CCEEECCCCCCCCEE	62.42	17644757
494	Acetylation	TSKGLADKVYFVPVT CCCCCCCCEEEEEEC	32.97	24489116
494	Ubiquitination	TSKGLADKVYFVPVT CCCCCCCCEEEEEEC	32.97	17644757
507	Ubiquitination	VTAEFVRKVILHERP ECHHHHHHHHHHCCC	28.46	17644757
543	Ubiquitination	EFEALGVKVLGTPID HHHHHCEEEECCCCC	29.91	17644757
571	Ubiquitination	AIDEINEKCAKSQAA HHHHHHHHHHHHHHH	34.70	17644757
574	Ubiquitination	EINEKCAKSQAANSV HHHHHHHHHHHHCCH	53.20	23749301
575	Phosphorylation	INEKCAKSQAANSVD HHHHHHHHHHHCCHH	13.41	28889911
589	Ubiquitination	DEALAAVKEIGFPVI HHHHHHHHHHCHHHH	38.60	17644757
615	Ubiquitination	SGFANNEKELVDLCN CCCCCCHHHHHHHHH	59.48	17644757
635	Ubiquitination	SPQVLVEKSMKGWKE CCCHHHHHHCCCCEE	48.66	17644757
638	Ubiquitination	VLVEKSMKGWKEVEY HHHHHHCCCCEEEEH	69.57	15699485
641	Ubiquitination	EKSMKGWKEVEYEVV HHHCCCCEEEEHHHH	61.63	15699485
719	Ubiquitination	YALNPVSKDYCIIEV EECCCCCCCEEEEEE	53.61	17644757
739	Ubiquitination	RSSALASKATGYPLA CHHHHHHHCCCCCHH	44.34	23749301
751	Ubiquitination	PLAYTAAKLGLNIPL CHHHHHHHHCCCCCH	40.39	17644757
762	Ubiquitination	NIPLNEVKNSVTKST CCCHHHHCCCCCHHC	37.01	23749301
764	Phosphorylation	PLNEVKNSVTKSTCA CHHHHCCCCCHHCEE	25.99	21440633
767	Ubiquitination	EVKNSVTKSTCACFE HHCCCCCHHCEEEEC	41.43	22817900
768	Phosphorylation	VKNSVTKSTCACFEP HCCCCCHHCEEEECC	21.25	28889911
783	Ubiquitination	SLDYCVVKMPRWDLK CCCEEEEECCCCCHH	23.84	17644757
793	Phosphorylation	RWDLKKFTRVSTELS CCCHHHHHHHHHHHH	38.75	21126336
796	Phosphorylation	LKKFTRVSTELSSSM HHHHHHHHHHHHHHC	16.93	21126336
797	Phosphorylation	KKFTRVSTELSSSMK HHHHHHHHHHHHHCC	37.78	28889911
804	Ubiquitination	TELSSSMKSVGEVMS HHHHHHCCHHHHHHH	43.89	24961812
805	Phosphorylation	ELSSSMKSVGEVMSI HHHHHCCHHHHHHHH	27.06	21440633
822	Acetylation	TFEEAIQKAIRSTEY HHHHHHHHHHHHHCC	39.40	24489116
864	Acetylation	AIANAFAKKGYSVDK HHHHHHHHCCCCHHH	40.03	24489116
864	Succinylation	AIANAFAKKGYSVDK HHHHHHHHCCCCHHH	40.03	23954790
864	Ubiquitination	AIANAFAKKGYSVDK HHHHHHHHCCCCHHH	40.03	17644757
865	Ubiquitination	IANAFAKKGYSVDKV HHHHHHHCCCCHHHH	60.70	17644757
867	Phosphorylation	NAFAKKGYSVDKVWE HHHHHCCCCHHHHHH	17.88	27017623
880	Acetylation	WEMTRIDKWFLNKLH HHHHHHCHHHHHHHH	37.16	24489116
885	Ubiquitination	IDKWFLNKLHDLVQF HCHHHHHHHHHHHHH	49.71	17644757
895	Acetylation	DLVQFAEKISSFGTK HHHHHHHHHHCCCCH	44.45	24489116
895	Ubiquitination	DLVQFAEKISSFGTK HHHHHHHHHHCCCCH	44.45	17644757
902	Acetylation	KISSFGTKEELPSLV HHHCCCCHHHHHHHH	49.96	24489116
902	Ubiquitination	KISSFGTKEELPSLV HHHCCCCHHHHHHHH	49.96	23749301
939	Ubiquitination	VAIRRLRKEYGITPF HHHHHHHHHHCCCHH	60.94	15699485
948	Ubiquitination	YGITPFVKQIDTVAA HCCCHHHHHCHHHHH	41.75	15699485
1015	Ubiquitination	TLRANNIKTIMVNYN HHHHCCCEEEEEECC	33.84	15699485
1080	Ubiquitination	TLHRENVKILGTSPD EEEHHCCEEEECCHH	43.74	23749301
1084	Phosphorylation	ENVKILGTSPDMIDS HCCEEEECCHHHHHC	33.37	28889911
1085	Phosphorylation	NVKILGTSPDMIDSA CCEEEECCHHHHHCH	19.66	25752575
1097	Ubiquitination	DSAENRYKFSRMLDQ HCHHHHHHHHHHHHH	33.36	15699485
1113	Acetylation	GVDQPAWKELTSMDE CCCCHHHHHCCCHHH	44.97	24489116
1113	Ubiquitination	GVDQPAWKELTSMDE CCCCHHHHHCCCHHH	44.97	17644757
1127	Ubiquitination	EAESFAEKVGYPVLV HHHHHHHHHCCCEEE	37.21	17644757
1130	Phosphorylation	SFAEKVGYPVLVRPS HHHHHHCCCEEECCH	7.99	22369663
1137	Phosphorylation	YPVLVRPSYVLSGAA CCEEECCHHHCCCCC	19.80	22369663
1138	Phosphorylation	PVLVRPSYVLSGAAM CEEECCHHHCCCCCC	14.21	22369663
1141	Phosphorylation	VRPSYVLSGAAMNTV ECCHHHCCCCCCCCC	19.15	22369663
1147	Phosphorylation	LSGAAMNTVYSKNDL CCCCCCCCCCCHHHH	14.03	22369663
1149	Phosphorylation	GAAMNTVYSKNDLES CCCCCCCCCHHHHHH	16.34	22369663
1150	Phosphorylation	AAMNTVYSKNDLESY CCCCCCCCHHHHHHH	22.20	22369663
1151	Ubiquitination	AMNTVYSKNDLESYL CCCCCCCHHHHHHHH	36.47	17644757
1174	Ubiquitination	DYPVVITKYIENAKE CCCEEEEEECCCCCC	32.86	15699485
1180	Succinylation	TKYIENAKEIEMDAV EEECCCCCCCCCEEH	71.46	23954790
1180	Ubiquitination	TKYIENAKEIEMDAV EEECCCCCCCCCEEH	71.46	23749301
1235	2-Hydroxyisobutyrylation	RIVVATAKIGKALKI EEEEEECCCCCCCCC	47.86	-
1235	Ubiquitination	RIVVATAKIGKALKI EEEEEECCCCCCCCC	47.86	15699485
1241	Ubiquitination	AKIGKALKITGPYNI CCCCCCCCCCCCCEE	42.98	17644757
1253	Acetylation	YNIQFIAKDNEIKVI CEEEEEEECCCEEEE	57.16	24489116
1253	Ubiquitination	YNIQFIAKDNEIKVI CEEEEEEECCCEEEE	57.16	17644757
1258	Acetylation	IAKDNEIKVIECNVR EEECCCEEEEEEEEE	30.86	24489116
1258	Ubiquitination	IAKDNEIKVIECNVR EEECCCEEEEEEEEE	30.86	15699485
1269	Phosphorylation	CNVRASRSFPFISKV EEEEECCCCCHHHHH	34.47	21440633
1275	Ubiquitination	RSFPFISKVVGVNLI CCCCHHHHHHCCCHH	35.80	17644757
1287	Ubiquitination	NLIELATKAIMGLPL CHHHHHHHHHHCCCC	30.24	17644757
1295	Phosphorylation	AIMGLPLTPYPVEKL HHHCCCCCCCCHHHC	20.88	28889911
1297	Phosphorylation	MGLPLTPYPVEKLPD HCCCCCCCCHHHCCC	18.06	24961812
1301	Acetylation	LTPYPVEKLPDDYVA CCCCCHHHCCCCCEE	66.60	24489116
1301	Ubiquitination	LTPYPVEKLPDDYVA CCCCCHHHCCCCCEE	66.60	23749301
1310	Acetylation	PDDYVAVKVPQFSFP CCCCEEEECCCCCCC	38.16	24489116
1310	Ubiquitination	PDDYVAVKVPQFSFP CCCCEEEECCCCCCC	38.16	17644757
1343	Acetylation	VATFGHSKYEAYLKS CCCCCCHHHHHHHHH	41.24	24489116
1349	Acetylation	SKYEAYLKSLLATGF HHHHHHHHHHHHHCC	26.78	24489116
1349	Ubiquitination	SKYEAYLKSLLATGF HHHHHHHHHHHHHCC	26.78	17644757
1350	Phosphorylation	KYEAYLKSLLATGFK HHHHHHHHHHHHCCC	26.48	22369663
1354	Phosphorylation	YLKSLLATGFKLPKK HHHHHHHHCCCCCCC	43.02	22369663
1357	Acetylation	SLLATGFKLPKKNIL HHHHHCCCCCCCCEE	66.29	24489116
1357	Ubiquitination	SLLATGFKLPKKNIL HHHHHCCCCCCCCEE	66.29	24961812
1360	Ubiquitination	ATGFKLPKKNILLSI HHCCCCCCCCEEEEE	69.73	17644757
1361	Ubiquitination	TGFKLPKKNILLSIG HCCCCCCCCEEEEEC	47.48	17644757
1371	Acetylation	LLSIGSYKEKQELLS EEEECCHHHHHHHHH	61.20	24489116
1371	Ubiquitination	LLSIGSYKEKQELLS EEEECCHHHHHHHHH	61.20	17644757
1382	Acetylation	ELLSSVQKLYNMGYK HHHHHHHHHHHHCHH	51.27	24489116
1452	Phosphorylation	NRFRRPASYVSKGYK CCCCCCHHHHCCCCC	28.84	28889911
1453	Phosphorylation	RFRRPASYVSKGYKT CCCCCHHHHCCCCCC	15.73	28889911
1476	Ubiquitination	VPLVTNVKCAKLLIE CCCCCCHHHHHHHHH	30.46	17644757
1479	Ubiquitination	VTNVKCAKLLIEAIS CCCHHHHHHHHHHHH	53.98	17644757
1486	Phosphorylation	KLLIEAISRNITLDV HHHHHHHHCCCEECC	26.73	30377154
1490	Phosphorylation	EAISRNITLDVSERD HHHHCCCEECCHHHH	22.06	28889911
1525	Ubiquitination	PNASHVIKGPAELKE CCHHHHCCCCHHHHH	58.72	17644757
1531	Acetylation	IKGPAELKETTRLFL CCCCHHHHHHHHHHH	44.51	24489116
1551	Phosphorylation	YCQLMPRSISGPVIT EEEECCCCCCCCEEC	18.42	28889911
1553	Phosphorylation	QLMPRSISGPVITDV EECCCCCCCCEECCH	37.99	25752575
1558	Phosphorylation	SISGPVITDVASLKA CCCCCEECCHHHHHH	25.34	27017623
1562	Phosphorylation	PVITDVASLKAANSV CEECCHHHHHHCCCC	30.19	27017623
1564	Ubiquitination	ITDVASLKAANSVSQ ECCHHHHHHCCCCCC	42.85	17644757
1568	Phosphorylation	ASLKAANSVSQDSSY HHHHHCCCCCCCCCC	20.58	19823750
1570	Phosphorylation	LKAANSVSQDSSYTD HHHCCCCCCCCCCCC	28.26	19823750
1573	Phosphorylation	ANSVSQDSSYTDFSF CCCCCCCCCCCCEEE	20.01	19823750
1574	Phosphorylation	NSVSQDSSYTDFSFT CCCCCCCCCCCEEEE	40.10	19823750
1575	Phosphorylation	SVSQDSSYTDFSFTI CCCCCCCCCCEEEEE	17.80	19823750
1576	Phosphorylation	VSQDSSYTDFSFTIA CCCCCCCCCEEEEEE	32.30	19823750
1579	Phosphorylation	DSSYTDFSFTIAGTA CCCCCCEEEEEEECC	25.04	19823750
1581	Phosphorylation	SYTDFSFTIAGTAHN CCCCEEEEEEECCCC	14.55	19823750
1585	Phosphorylation	FSFTIAGTAHNAHSV EEEEEEECCCCCCCC	18.74	19823750
1591	Phosphorylation	GTAHNAHSVTQSASK ECCCCCCCCCCCHHH	25.17	19823750
1593	Phosphorylation	AHNAHSVTQSASKVT CCCCCCCCCCHHHHH	21.59	19823750
1595	Phosphorylation	NAHSVTQSASKVTAL CCCCCCCCHHHHHHH	25.74	19823750
1597	Phosphorylation	HSVTQSASKVTALFL CCCCCCHHHHHHHHH	32.67	19823750
1598	Ubiquitination	SVTQSASKVTALFLP CCCCCHHHHHHHHHC	43.23	17644757
1610	Ubiquitination	FLPLRELKNKITAVA HHCHHHHHHHHHHHH	51.98	17644757
1612	Acetylation	PLRELKNKITAVAEL CHHHHHHHHHHHHHH	39.59	24489116
1612	Ubiquitination	PLRELKNKITAVAEL CHHHHHHHHHHHHHH	39.59	17644757
1627	Ubiquitination	LNQWPTEKQVIAEAK HHCCCCHHHHHHHHH	52.95	17644757
1634	Ubiquitination	KQVIAEAKTADLASV HHHHHHHHHCCHHHH	35.43	17644757
1771	Ubiquitination	RLHDNPAKIFNIPTQ ECCCCCCHHCCCCCC	49.43	17644757
1801	Acetylation	KRWSPFNKDMNGGIE CCCCCCCCCCCCCEE	59.75	24489116
1816	Phosphorylation	RVVYNGETLVLSGEL EEEECCCEEEEEEEE	24.46	21126336
1837	Phosphorylation	GKCIVNPSPASITAS CCEEECCCCCCEEEE	28.09	30377154
1840	Phosphorylation	IVNPSPASITASAEL EECCCCCCEEEEEEE	24.69	30377154
1844	Phosphorylation	SPASITASAELQSTS CCCCEEEEEEECCCC	17.39	30377154
1849	Phosphorylation	TASAELQSTSAKRRF EEEEEECCCCCCCCC	36.63	30377154
1853	Ubiquitination	ELQSTSAKRRFSITE EECCCCCCCCCCCCH	43.82	23749301
1857	Phosphorylation	TSAKRRFSITEEAIA CCCCCCCCCCHHHHH	27.13	22369663
1859	Phosphorylation	AKRRFSITEEAIADN CCCCCCCCHHHHHHC	26.95	25521595
1917	Acetylation	GRHILSIKQFKRSDF CCEEEEEEEECCCCH	46.43	24489116
1948	Ubiquitination	EGVLDLMKGHVITTI HCHHHHHCCCEEEEE	53.84	17644757
1986	Phosphorylation	VNVNPLVSSVKKGET EEECCCCCCCCCCCC	36.78	28889911
1987	Phosphorylation	NVNPLVSSVKKGETL EECCCCCCCCCCCCH	30.40	30377154
1989	Succinylation	NPLVSSVKKGETLQD CCCCCCCCCCCCHHH	57.94	23954790
1989	Ubiquitination	NPLVSSVKKGETLQD CCCCCCCCCCCCHHH	57.94	22106047
1990	Ubiquitination	PLVSSVKKGETLQDT CCCCCCCCCCCHHHH	60.88	17644757
1997	Phosphorylation	KGETLQDTIRTLACY CCCCHHHHHHHHHHH	10.21	28889911
2108	Ubiquitination	GLREELRKAGLLGVE HHHHHHHHCCCCCCE	60.47	17644757
2126	Ubiquitination	LTPHIISKTDVLYCT CCCCCCCCCCEEEEE	38.03	17644757
2142	Phosphorylation	VQEERFNSPEEYARL CCHHHCCCHHHHHHC	30.86	25752575
2150	Acetylation	PEEYARLKDTYIVDN HHHHHHCCCEEEECC	42.33	25381059
2150	Ubiquitination	PEEYARLKDTYIVDN HHHHHHCCCEEEECC	42.33	17644757
2158	Acetylation	DTYIVDNKILAHAKE CEEEECCCHHHHHHH	34.33	24489116
2158	Ubiquitination	DTYIVDNKILAHAKE CEEEECCCHHHHHHH	34.33	24961812
2164	Acetylation	NKILAHAKENMAIMH CCHHHHHHHHHCCCC	39.49	24489116
2164	Ubiquitination	NKILAHAKENMAIMH CCHHHHHHHHHCCCC	39.49	17644757
2180	Acetylation	LPRVNEIKEEVDYDH CCCHHHHHHHCCCHH	41.46	24489116
2180	Succinylation	LPRVNEIKEEVDYDH CCCHHHHHHHCCCHH	41.46	23954790
2180	Ubiquitination	LPRVNEIKEEVDYDH CCCHHHHHHHCCCHH	41.46	17644757
2196	Acetylation	AAYFRQMKYGLFVRM HHHHHHHHHHHHHHH	28.03	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1857	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1857	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PYR1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYR1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAM7_YEAST	NAM7	genetic	12172963
NMD2_YEAST	NMD2	genetic	12172963
UPF3_YEAST	UPF3	genetic	12172963
STI1_YEAST	STI1	physical	18467557
CBS_YEAST	CYS4	genetic	21623372
CYS3_YEAST	CYS3	genetic	21623372
COQ2_YEAST	COQ2	genetic	21623372
CEM1_YEAST	CEM1	genetic	21623372
KCS1_YEAST	KCS1	genetic	21623372
MET5_YEAST	MET5	genetic	21623372
CYSKL_YEAST	YGR012W	genetic	21623372
HFA1_YEAST	HFA1	genetic	21623372
ARA1_YEAST	ARA1	genetic	21623372
ODP2_YEAST	LAT1	genetic	21623372
ODPA_YEAST	PDA1	genetic	21623372
ENO1_YEAST	ENO1	genetic	21623372
ETR1_YEAST	ETR1	genetic	21623372
COX9_YEAST	COX9	genetic	21623372
IMDH3_YEAST	IMD3	genetic	21623372
PANB_YEAST	ECM31	genetic	21623372
ERG2_YEAST	ERG2	genetic	21623372
PPT2_YEAST	PPT2	genetic	21623372
LPP1_YEAST	LPP1	genetic	21623372
ALDH2_YEAST	ALD2	genetic	21623372
FMS1_YEAST	FMS1	genetic	21623372
ATP14_YEAST	ATP14	genetic	21623372
COQ4_YEAST	COQ4	genetic	21623372
INP54_YEAST	INP54	genetic	21623372
MAK5_YEAST	MAK5	genetic	27708008
CDK1_YEAST	CDC28	genetic	27708008
ERF3_YEAST	SUP35	genetic	27708008
GPI11_YEAST	GPI11	genetic	27708008
PTI1_YEAST	PTI1	genetic	27708008
CP51_YEAST	ERG11	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
STU2_YEAST	STU2	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
MVD1_YEAST	MVD1	genetic	27708008
DYR_YEAST	DFR1	genetic	27708008
SEC63_YEAST	SEC63	genetic	27708008
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PYR1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1452; TYR-1453;SER-1553; SER-1857; THR-1859; SER-1986 AND SER-2142, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND MASSSPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND MASSSPECTROMETRY.	17330950 [Abstract]
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND MASSSPECTROMETRY.	15665377 [Abstract]
"Yeast carbamoyl-phosphate-synthetase--aspartate-transcarbamylasemultidomain protein is phosphorylated in vitro by cAMP-dependentprotein kinase."; Denis-Duphil M., Lecaer J.-P., Hardie D.G., Carrey E.A.; Eur. J. Biochem. 193:581-587(1990). Cited for: PROTEIN SEQUENCE OF 1855-1874, AND PHOSPHORYLATION AT SER-1857.	1977585 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1859, AND MASSSPECTROMETRY.	17563356 [Abstract]