| UniProt ID | STI1_YEAST | |
|---|---|---|
| UniProt AC | P15705 | |
| Protein Name | Heat shock protein STI1 | |
| Gene Name | STI1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 589 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | May play a role in mediating the heat shock response of some HSP70 genes. It is required for optimal growth of yeast cells at both low and high temperature.. | |
| Protein Sequence | MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLTADEYK ------CCCCHHHHH | 34.13 | 28889911 | |
| 8 | Phosphorylation | MSLTADEYKQQGNAA CCCCHHHHHHHCCCC | 18.04 | 30377154 | |
| 9 | Succinylation | SLTADEYKQQGNAAF CCCHHHHHHHCCCCC | 33.81 | 23954790 | |
| 9 | Ubiquitination | SLTADEYKQQGNAAF CCCHHHHHHHCCCCC | 33.81 | 24961812 | |
| 19 | Acetylation | GNAAFTAKDYDKAIE CCCCCCCCCHHHHHH | 54.48 | 24489116 | |
| 19 | Succinylation | GNAAFTAKDYDKAIE CCCCCCCCCHHHHHH | 54.48 | 23954790 | |
| 23 | Acetylation | FTAKDYDKAIELFTK CCCCCHHHHHHHHHH | 45.06 | 24489116 | |
| 23 | Ubiquitination | FTAKDYDKAIELFTK CCCCCHHHHHHHHHH | 45.06 | 24961812 | |
| 30 | Ubiquitination | KAIELFTKAIEVSET HHHHHHHHHHHCCCC | 39.78 | 17644757 | |
| 35 | Phosphorylation | FTKAIEVSETPNHVL HHHHHHCCCCCCCEE | 23.98 | 22369663 | |
| 37 | Phosphorylation | KAIEVSETPNHVLYS HHHHCCCCCCCEEEC | 23.14 | 23749301 | |
| 47 | Phosphorylation | HVLYSNRSACYTSLK CEEECCCHHHHHHHH | 27.26 | 30377154 | |
| 54 | Acetylation | SACYTSLKKFSDALN HHHHHHHHHHHHHHH | 52.09 | 25381059 | |
| 54 | Ubiquitination | SACYTSLKKFSDALN HHHHHHHHHHHHHHH | 52.09 | 23749301 | |
| 55 | Acetylation | ACYTSLKKFSDALND HHHHHHHHHHHHHHC | 56.23 | 24489116 | |
| 55 | Ubiquitination | ACYTSLKKFSDALND HHHHHHHHHHHHHHC | 56.23 | 22817900 | |
| 68 | Ubiquitination | NDANECVKINPSWSK HCHHHCEECCCHHHC | 48.72 | 23749301 | |
| 75 | 2-Hydroxyisobutyrylation | KINPSWSKGYNRLGA ECCCHHHCCCCCCCH | 60.19 | - | |
| 75 | Acetylation | KINPSWSKGYNRLGA ECCCHHHCCCCCCCH | 60.19 | 24489116 | |
| 75 | Ubiquitination | KINPSWSKGYNRLGA ECCCHHHCCCCCCCH | 60.19 | 23749301 | |
| 98 | Acetylation | DEAESNYKKALELDA HHHHHHHHHHHHHHH | 35.50 | 24489116 | |
| 98 | Succinylation | DEAESNYKKALELDA HHHHHHHHHHHHHHH | 35.50 | 23954790 | |
| 98 | Ubiquitination | DEAESNYKKALELDA HHHHHHHHHHHHHHH | 35.50 | 17644757 | |
| 99 | Ubiquitination | EAESNYKKALELDAS HHHHHHHHHHHHHHH | 48.09 | 23749301 | |
| 106 | Phosphorylation | KALELDASNKAAKEG HHHHHHHHHHHHHHC | 38.23 | 22369663 | |
| 108 | 2-Hydroxyisobutyrylation | LELDASNKAAKEGLD HHHHHHHHHHHHCHH | 47.42 | - | |
| 108 | Ubiquitination | LELDASNKAAKEGLD HHHHHHHHHHHHCHH | 47.42 | 23749301 | |
| 111 | 2-Hydroxyisobutyrylation | DASNKAAKEGLDQVH HHHHHHHHHCHHHHH | 58.12 | - | |
| 111 | Acetylation | DASNKAAKEGLDQVH HHHHHHHHHCHHHHH | 58.12 | 25381059 | |
| 111 | Ubiquitination | DASNKAAKEGLDQVH HHHHHHHHHCHHHHH | 58.12 | 22817900 | |
| 146 | Acetylation | PNLIENLKKNPKTSE HHHHHHHHHCCCHHH | 63.18 | 24489116 | |
| 146 | Succinylation | PNLIENLKKNPKTSE HHHHHHHHHCCCHHH | 63.18 | 23954790 | |
| 150 | Ubiquitination | ENLKKNPKTSEMMKD HHHHHCCCHHHHHCC | 74.26 | 23749301 | |
| 156 | Acetylation | PKTSEMMKDPQLVAK CCHHHHHCCHHHHHH | 66.02 | 24489116 | |
| 156 | Ubiquitination | PKTSEMMKDPQLVAK CCHHHHHCCHHHHHH | 66.02 | 23749301 | |
| 163 | Acetylation | KDPQLVAKLIGYKQN CCHHHHHHHHCCCCC | 32.91 | 22865919 | |
| 163 | Ubiquitination | KDPQLVAKLIGYKQN CCHHHHHHHHCCCCC | 32.91 | 24961812 | |
| 168 | Ubiquitination | VAKLIGYKQNPQAIG HHHHHCCCCCHHHHC | 38.08 | 23749301 | |
| 215 | Acetylation | PKEPETSKSTEQKKD CCCCCCCCCCCHHCC | 69.67 | 25381059 | |
| 227 | Phosphorylation | KKDAEPQSDSTTSKE HCCCCCCCCCCCCCC | 44.22 | 22369663 | |
| 229 | Phosphorylation | DAEPQSDSTTSKENS CCCCCCCCCCCCCCC | 38.54 | 22369663 | |
| 230 | Phosphorylation | AEPQSDSTTSKENSS CCCCCCCCCCCCCCC | 39.83 | 22369663 | |
| 231 | Phosphorylation | EPQSDSTTSKENSSK CCCCCCCCCCCCCCC | 41.58 | 22369663 | |
| 232 | Phosphorylation | PQSDSTTSKENSSKA CCCCCCCCCCCCCCC | 37.75 | 22369663 | |
| 233 | Ubiquitination | QSDSTTSKENSSKAP CCCCCCCCCCCCCCC | 59.84 | 23749301 | |
| 236 | Phosphorylation | STTSKENSSKAPQKE CCCCCCCCCCCCCCH | 34.02 | 29136822 | |
| 237 | Phosphorylation | TTSKENSSKAPQKEE CCCCCCCCCCCCCHH | 44.40 | 27717283 | |
| 238 | Acetylation | TSKENSSKAPQKEES CCCCCCCCCCCCHHC | 65.00 | 25381059 | |
| 242 | Acetylation | NSSKAPQKEESKESE CCCCCCCCHHCCCCC | 63.49 | 25381059 | |
| 245 | Phosphorylation | KAPQKEESKESEPME CCCCCHHCCCCCCCC | 42.70 | 27717283 | |
| 248 | Phosphorylation | QKEESKESEPMEVDE CCHHCCCCCCCCCCC | 51.22 | 22369663 | |
| 258 | Phosphorylation | MEVDEDDSKIEADKE CCCCCCCHHCHHHHH | 48.10 | 22369663 | |
| 259 | Acetylation | EVDEDDSKIEADKEK CCCCCCHHCHHHHHH | 52.11 | 24489116 | |
| 264 | Acetylation | DSKIEADKEKAEGNK CHHCHHHHHHHCCCH | 69.07 | 24489116 | |
| 266 | 2-Hydroxyisobutyrylation | KIEADKEKAEGNKFY HCHHHHHHHCCCHHH | 58.44 | - | |
| 271 | Acetylation | KEKAEGNKFYKARQF HHHHCCCHHHHHHHH | 62.01 | 25381059 | |
| 274 | Ubiquitination | AEGNKFYKARQFDEA HCCCHHHHHHHHHHH | 39.98 | 17644757 | |
| 287 | Ubiquitination | EAIEHYNKAWELHKD HHHHHHHHHHHHHCC | 47.94 | 17644757 | |
| 293 | Acetylation | NKAWELHKDITYLNN HHHHHHHCCHHHHCH | 64.55 | 24489116 | |
| 293 | Ubiquitination | NKAWELHKDITYLNN HHHHHHHCCHHHHCH | 64.55 | 15699485 | |
| 308 | Acetylation | RAAAEYEKGEYETAI HHHHHHHCCCHHHHH | 57.02 | 24489116 | |
| 308 | Ubiquitination | RAAAEYEKGEYETAI HHHHHHHCCCHHHHH | 57.02 | 23749301 | |
| 311 | Phosphorylation | AEYEKGEYETAISTL HHHHCCCHHHHHHHH | 27.52 | 27017623 | |
| 316 | Phosphorylation | GEYETAISTLNDAVE CCHHHHHHHHHHHHH | 25.12 | 27017623 | |
| 333 | Acetylation | REMRADYKVISKSFA HHHHCHHHHHHHHHH | 33.37 | 24489116 | |
| 333 | Succinylation | REMRADYKVISKSFA HHHHCHHHHHHHHHH | 33.37 | 23954790 | |
| 337 | Acetylation | ADYKVISKSFARIGN CHHHHHHHHHHHHHH | 38.17 | 24489116 | |
| 348 | Acetylation | RIGNAYHKLGDLKKT HHHHHHHHHCCHHHH | 41.30 | 24489116 | |
| 355 | Phosphorylation | KLGDLKKTIEYYQKS HHCCHHHHHHHHHHH | 19.90 | 28889911 | |
| 359 | Phosphorylation | LKKTIEYYQKSLTEH HHHHHHHHHHHHHHH | 9.18 | 27017623 | |
| 361 | 2-Hydroxyisobutyrylation | KTIEYYQKSLTEHRT HHHHHHHHHHHHHHH | 31.17 | - | |
| 361 | Acetylation | KTIEYYQKSLTEHRT HHHHHHHHHHHHHHH | 31.17 | 24489116 | |
| 364 | Phosphorylation | EYYQKSLTEHRTADI HHHHHHHHHHHHHHH | 36.52 | 27017623 | |
| 374 | 2-Hydroxyisobutyrylation | RTADILTKLRNAEKE HHHHHHHHHHHHHHH | 41.84 | - | |
| 374 | Acetylation | RTADILTKLRNAEKE HHHHHHHHHHHHHHH | 41.84 | 24489116 | |
| 384 | Ubiquitination | NAEKELKKAEAEAYV HHHHHHHHHHHHHHC | 65.17 | 22106047 | |
| 395 | Acetylation | EAYVNPEKAEEARLE HHHCCHHHHHHHHHC | 63.46 | 24489116 | |
| 395 | Ubiquitination | EAYVNPEKAEEARLE HHHCCHHHHHHHHHC | 63.46 | 23749301 | |
| 404 | 2-Hydroxyisobutyrylation | EEARLEGKEYFTKSD HHHHHCCCHHCCCCC | 39.61 | - | |
| 404 | Acetylation | EEARLEGKEYFTKSD HHHHHCCCHHCCCCC | 39.61 | 24489116 | |
| 404 | Ubiquitination | EEARLEGKEYFTKSD HHHHHCCCHHCCCCC | 39.61 | 23749301 | |
| 409 | Acetylation | EGKEYFTKSDWPNAV CCCHHCCCCCCHHHH | 36.20 | 24489116 | |
| 409 | Succinylation | EGKEYFTKSDWPNAV CCCHHCCCCCCHHHH | 36.20 | 23954790 | |
| 409 | Ubiquitination | EGKEYFTKSDWPNAV CCCHHCCCCCCHHHH | 36.20 | 23749301 | |
| 410 | Phosphorylation | GKEYFTKSDWPNAVK CCHHCCCCCCHHHHH | 41.68 | 22369663 | |
| 442 | Acetylation | NRAAALAKLMSFPEA HHHHHHHHHHCCHHH | 45.64 | 24489116 | |
| 442 | Ubiquitination | NRAAALAKLMSFPEA HHHHHHHHHHCCHHH | 45.64 | 24961812 | |
| 455 | Acetylation | EAIADCNKAIEKDPN HHHHHHHHHHHHCCH | 58.01 | 24489116 | |
| 455 | Ubiquitination | EAIADCNKAIEKDPN HHHHHHHHHHHHCCH | 58.01 | 15699485 | |
| 459 | Acetylation | DCNKAIEKDPNFVRA HHHHHHHHCCHHHHH | 72.82 | 24489116 | |
| 472 | Phosphorylation | RAYIRKATAQIAVKE HHHHHHHHHHHHHHH | 23.33 | 30377154 | |
| 493 | 2-Hydroxyisobutyrylation | TLDAARTKDAEVNNG HHHHHHHCCCCCCCC | 49.76 | - | |
| 493 | Ubiquitination | TLDAARTKDAEVNNG HHHHHHHCCCCCCCC | 49.76 | 23749301 | |
| 501 | Phosphorylation | DAEVNNGSSAREIDQ CCCCCCCCCHHHHHH | 23.97 | 28889911 | |
| 512 | Acetylation | EIDQLYYKASQQRFQ HHHHHHHHHHHHHCC | 28.18 | 24489116 | |
| 512 | Ubiquitination | EIDQLYYKASQQRFQ HHHHHHHHHHHHHCC | 28.18 | 23749301 | |
| 522 | Phosphorylation | QQRFQPGTSNETPEE HHHCCCCCCCCCHHH | 34.75 | 28889911 | |
| 523 | Phosphorylation | QRFQPGTSNETPEET HHCCCCCCCCCHHHH | 38.29 | 28889911 | |
| 526 | Phosphorylation | QPGTSNETPEETYQR CCCCCCCCHHHHHHH | 40.01 | 22369663 | |
| 530 | Phosphorylation | SNETPEETYQRAMKD CCCCHHHHHHHHHCC | 24.24 | 22369663 | |
| 574 | Acetylation | MKNPEVFKKIQTLIA HHCHHHHHHHHHHHH | 54.89 | 25381059 | |
| 574 | Succinylation | MKNPEVFKKIQTLIA HHCHHHHHHHHHHHH | 54.89 | 23954790 | |
| 574 | Ubiquitination | MKNPEVFKKIQTLIA HHCHHHHHHHHHHHH | 54.89 | 23749301 | |
| 575 | Ubiquitination | KNPEVFKKIQTLIAA HCHHHHHHHHHHHHH | 28.69 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STI1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STI1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STI1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-227 AND SER-523,AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, AND MASSSPECTROMETRY. | |
