EPS1_YEAST - dbPTM
EPS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EPS1_YEAST
UniProt AC P40557
Protein Name ER-retained PMA1-suppressing protein 1
Gene Name EPS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 701
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein .
Protein Description Acts as a membrane-bound chaperone in endoplasmic reticulum quality control. Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery..
Protein Sequence MKMNLKRLVVTFFSCITFLLKFTIAAAEPPEGFPEPLNPTNFKEELSKGLHIIDFYSPYCPHCKHLAPVWMETWEEFKEESKTLNITFSQVNCIESADLCGDENIEYFPEIRLYNPSGYIKSFTETPRTKESLIAFARRESMDPNNLDTDLDSAKSESQYLEGFDFLELIAGKATRPHLVSFWPTKDMKNSDDSLEFKNCDKCHEFQRTWKIISRQLAVDDINTGHVNCESNPTICEELGFGDLVKITNHRADREPKVALVLPNKTSNNLFDYPNGYSAKSDGYVDFARRTFTNSKFPNITEGELEKKANRDIDFLQERGRVTNNDIHLVFSYDPETVVIEDFDILEYLIEPLSKIPNIYLHQIDKNLINLSRNLFGRMYEKINYDASQTQKVFNKEYFTMNTVTQLPTFFMFKDGDPISYVFPGYSTTEMRNIDAIMDWVKKYSNPLVTEVDSSNLKKLISFQTKSYSDLAIQLISSTDHKHIKGSNKLIKNLLLASWEYEHIRMENNFEEINERRARKADGIKKIKEKKAPANKIVDKMREEIPHMDQKKLLLGYLDISKEKNFFRKYGITGEYKIGDVIIIDKSNNYYYNKDNFGNSLTSNNPQLLREAFVSLNIPSKALYSSKLKGRLINSPFHNVLSFLDIIHGNGMPGYLIVIVLFIAILKGPSIYRRYKVRKHYRAKRNAVGILGNMEKKKNQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48UbiquitinationNFKEELSKGLHIIDF
CHHHHHHCCCEEEEC		77.4617644757
64UbiquitinationSPYCPHCKHLAPVWM
CCCCCCCCCCCHHHH		38.3217644757
85N-linked_GlycosylationKEESKTLNITFSQVN
HHHHHCEEEEEECCC		36.16-
121UbiquitinationYNPSGYIKSFTETPR
ECCCCCCCCCCCCCC		30.9117644757
155UbiquitinationDTDLDSAKSESQYLE
CCCHHHHHHHHHHHC		59.7217644757
173UbiquitinationFLELIAGKATRPHLV
HHHHHCCCCCCCEEE		37.2517644757
264N-linked_GlycosylationKVALVLPNKTSNNLF
CEEEECCCCCCCCCC		56.95-
299N-linked_GlycosylationFTNSKFPNITEGELE
CCCCCCCCCCHHHHH		57.87-
355UbiquitinationYLIEPLSKIPNIYLH
HHHHHHHCCCCEEEH		70.6217644757
366UbiquitinationIYLHQIDKNLINLSR
EEEHHHCHHHHHHHH		56.1117644757
370N-linked_GlycosylationQIDKNLINLSRNLFG
HHCHHHHHHHHHHHH		34.82-
414UbiquitinationLPTFFMFKDGDPISY
CCEEEECCCCCCEEE		49.3517644757
442UbiquitinationDAIMDWVKKYSNPLV
HHHHHHHHHHCCCCE		41.5617644757
443UbiquitinationAIMDWVKKYSNPLVT
HHHHHHHHHCCCCEE		44.2717644757
445PhosphorylationMDWVKKYSNPLVTEV
HHHHHHHCCCCEEEE		40.6328889911
458UbiquitinationEVDSSNLKKLISFQT
EECCCHHHHHHHCEE		50.1917644757
459UbiquitinationVDSSNLKKLISFQTK
ECCCHHHHHHHCEEC		54.9717644757
466UbiquitinationKLISFQTKSYSDLAI
HHHHCEECCHHHHHH		36.2917644757
482UbiquitinationLISSTDHKHIKGSNK
HHHCCCCCCCCCCCH		50.2417644757
482AcetylationLISSTDHKHIKGSNK
HHHCCCCCCCCCCCH		50.2424489116
492UbiquitinationKGSNKLIKNLLLASW
CCCCHHHHHHHHHHH		52.5617644757
551UbiquitinationEIPHMDQKKLLLGYL
HCCCCCHHHHHHHHH		40.9217644757
552UbiquitinationIPHMDQKKLLLGYLD
CCCCCHHHHHHHHHH		38.4417644757
562UbiquitinationLGYLDISKEKNFFRK
HHHHHHHCCCCHHHH		73.3917644757
564UbiquitinationYLDISKEKNFFRKYG
HHHHHCCCCHHHHHC		63.8917644757
586UbiquitinationGDVIIIDKSNNYYYN
CCEEEEECCCCEEEC		44.6819722269
594UbiquitinationSNNYYYNKDNFGNSL
CCCEEECCCCCCCCC		37.6219722269
696UbiquitinationGILGNMEKKKNQD--
HHCCCCHHHCCCC--		59.2723749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EPS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EPS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EPS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SECU_YEASTPDS1physical
9635435
SEC22_YEASTSEC22genetic
16269340
GOSR1_YEASTGOS1genetic
16269340
GUP1_YEASTGUP1genetic
16269340
GST1_YEASTGTT1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
CTR2_YEASTCTR2genetic
16269340
HAC1_YEASTHAC1genetic
16269340
SSB1_YEASTSSB1physical
19536198
UBC7_YEASTUBC7genetic
12881414
UBC6_YEASTUBC6genetic
12881414
MKAR_YEASTIFA38physical
16093310
YIQ6_YEASTYIL166Cphysical
16093310
RPB7_YEASTRPB7genetic
27708008
PRP6_YEASTPRP6genetic
27708008
TRS20_YEASTTRS20genetic
27708008
NSE4_YEASTNSE4genetic
27708008
CDC1_YEASTCDC1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
TEL2_YEASTTEL2genetic
27708008
MED6_YEASTMED6genetic
27708008
ARP4_YEASTARP4genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
FNTA_YEASTRAM2genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
NUF2_YEASTNUF2genetic
27708008
CLP1_YEASTCLP1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
OST4_YEASTOST4genetic
27708008
SIC1_YEASTSIC1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
KPC1_YEASTPKC1genetic
29674565
GET2_YEASTGET2genetic
29674565
CHO2_YEASTCHO2genetic
29674565
TRS23_YEASTTRS23genetic
29674565
LPP1_YEASTLPP1genetic
29674565
KRE28_YEASTKRE28genetic
29674565
MED4_YEASTMED4genetic
29674565
TRS20_YEASTTRS20genetic
29674565
THRC_YEASTTHR4genetic
29674565
INO2_YEASTINO2genetic
29674565
SLT2_YEASTSLT2genetic
29674565
DCP2_YEASTDCP2genetic
29674565
NAB3_YEASTNAB3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EPS1_YEAST

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Related Literatures of Post-Translational Modification

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