| UniProt ID | TEL2_YEAST | |
|---|---|---|
| UniProt AC | P53038 | |
| Protein Name | Telomere length regulation protein TEL2 | |
| Gene Name | TEL2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 688 | |
| Subcellular Localization | Nucleus . Chromosome, telomere . | |
| Protein Description | Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.. | |
| Protein Sequence | MVLETLKQGLDSSQIHEALIQLDSYPREPVDLDASMVLIKFVIPVYPSLPERSKVILRRLASKSFTFLCQIVTFSRTISGRDGLQEIRIYQEILEDIISFEPGCLTFYLKASTTSKADRDSIKALFFGSKLFNVLANRIDMAKYLGYLRLQWKFLLESNETDPPGFLGEWLVSSFLLNPVLAADMLLGELFLLKESYFFSFQKIISASSLIDQKRLIAKFLLPYIQVIVTLENLNDVRKILRRFDLDKIISLSVLFEIQSLPLKEVIVRLMSNHSSTKFVSALVSKFADFTDEEVDTKTCELLVLFAVHNLNHSQREEIAHDERFLNGVTKHLGSNEREARERAMFIAKLLSGGHLKYESDFKINIPNVKFESNSDDKIIDFQSLKNPSICNTQTDVGKDKITEVSGHVQSLTLDCSDSDDEDENDEREIVKRIVFLKDLMKEYEKTGESRKAPLIPLLKQTVKLIRQKADFQLEVGYYAQGILSSIVCLNNEFDEPLFEQWRINALTSILVVLPEKVNGAINILFNSELSLQQRMSLLSALGLSARELRGLDDPTIVKPKFDFPTNRLPWDDQSHHNSRLVEVQESTSMIKKTKTVWKSRKLGKDREKGTQNRFRKYAGLFFYPLAHGWLNGIDVGTYNQLFKSHYLTTLRIIYSCANPVHDFESMTELMNHIISSAIEEGISLNKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 384 | Phosphorylation | DKIIDFQSLKNPSIC CCEEEHHHCCCCCCC | 41.11 | 29136822 | |
| 389 | Phosphorylation | FQSLKNPSICNTQTD HHHCCCCCCCCCCCC | 49.52 | 29136822 | |
| 393 | Phosphorylation | KNPSICNTQTDVGKD CCCCCCCCCCCCCCC | 28.56 | 29136822 | |
| 395 | Phosphorylation | PSICNTQTDVGKDKI CCCCCCCCCCCCCHH | 30.52 | 29136822 | |
| 399 | Ubiquitination | NTQTDVGKDKITEVS CCCCCCCCCHHHEEE | 56.55 | 23749301 | |
| 406 | Phosphorylation | KDKITEVSGHVQSLT CCHHHEEECEEEEEE | 19.56 | 19779198 | |
| 413 | Phosphorylation | SGHVQSLTLDCSDSD ECEEEEEEEECCCCC | 26.29 | 19779198 | |
| 417 | Phosphorylation | QSLTLDCSDSDDEDE EEEEEECCCCCCCCC | 39.55 | 28889911 | |
| 419 | Phosphorylation | LTLDCSDSDDEDEND EEEECCCCCCCCCCC | 30.57 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TEL2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TEL2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TEL2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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