BGL2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BGL2_YEAST
• UniProt AC: P15703
• Protein Name: Glucan 1,3-beta-glucosidase
• Gene Name: BGL2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 313
• Subcellular Localization: Secreted, cell wall . Tightly bound to cell wall.
• Protein Description: Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase..
• Protein Sequence: MRFSTTLATAATALFFTASQVSAIGELAFNLGVKNNDGTCKSTSDYETELQALKSYTSTVKVYAASDCNTLQNLGPAAEAEGFTIFVGVWPTDDSHYAAEKAALQTYLPKIKESTVAGFLVGSEALYRNDLTASQLSDKINDVRSVVADISDSDGKSYSGKQVGTVDSWNVLVAGYNSAVIEASDFVMANAFSYWQGQTMQNASYSFFDDIMQALQVIQSTKGSTDITFWVGETGWPTDGTNFESSYPSVDNAKQFWKEGICSMRAWGVNVIVFEAFDEDWKPNTSGTSDVEKHWGVFTSSDNLKYSLDCDFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Ubiquitination	LAFNLGVKNNDGTCK HHHHCCCCCCCCCCC	48.51	15699485
41	Ubiquitination	KNNDGTCKSTSDYET CCCCCCCCCCCCHHH	57.52	23749301
44	Phosphorylation	DGTCKSTSDYETELQ CCCCCCCCCHHHHHH	45.33	27017623
54	Acetylation	ETELQALKSYTSTVK HHHHHHHHHCCCEEE	44.42	24489116
54	Ubiquitination	ETELQALKSYTSTVK HHHHHHHHHCCCEEE	44.42	23749301
110	Acetylation	ALQTYLPKIKESTVA HHHHHCHHHCCCHHH	64.91	24489116
110	Ubiquitination	ALQTYLPKIKESTVA HHHHHCHHHCCCHHH	64.91	17644757
112	Ubiquitination	QTYLPKIKESTVAGF HHHCHHHCCCHHHHE	52.30	17644757
123	Phosphorylation	VAGFLVGSEALYRND HHHEEECCHHHHCCC	16.53	27017623
127	Phosphorylation	LVGSEALYRNDLTAS EECCHHHHCCCCCHH	17.89	27017623
139	Ubiquitination	TASQLSDKINDVRSV CHHHHHHHHHHHHHH	39.78	23749301
139	Acetylation	TASQLSDKINDVRSV CHHHHHHHHHHHHHH	39.78	24489116
145	Phosphorylation	DKINDVRSVVADISD HHHHHHHHHEEECCC	22.31	27017623
151	Phosphorylation	RSVVADISDSDGKSY HHHEEECCCCCCCCC	31.45	27017623
156	Ubiquitination	DISDSDGKSYSGKQV ECCCCCCCCCCCCCC	51.73	23749301
156	Acetylation	DISDSDGKSYSGKQV ECCCCCCCCCCCCCC	51.73	24489116
156	Succinylation	DISDSDGKSYSGKQV ECCCCCCCCCCCCCC	51.73	23954790
157	Phosphorylation	ISDSDGKSYSGKQVG CCCCCCCCCCCCCCE	30.02	23749301
202	N-linked_Glycosylation	WQGQTMQNASYSFFD HCCCCCCCCCHHCHH	21.74	-
258	Ubiquitination	DNAKQFWKEGICSMR HHHHHHHHHCCHHHH	47.56	23749301
258	Acetylation	DNAKQFWKEGICSMR HHHHHHHHHCCHHHH	47.56	24489116
284	N-linked_Glycosylation	FDEDWKPNTSGTSDV CCCCCCCCCCCCCCH	43.05	-
293	Ubiquitination	SGTSDVEKHWGVFTS CCCCCHHHHCEEEEC	44.50	17644757
300	Phosphorylation	KHWGVFTSSDNLKYS HHCEEEECCCCCEEE	24.99	29734811
305	Ubiquitination	FTSSDNLKYSLDCDF EECCCCCEEEEECCC	38.76	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BGL2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BGL2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BGL2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHS3_YEAST	CHS3	genetic	14574112
SCW10_YEAST	SCW10	genetic	15470100
ADH3_YEAST	ADH3	genetic	21623372
ARGJ_YEAST	ARG7	genetic	21623372
CEM1_YEAST	CEM1	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
GGPPS_YEAST	BTS1	genetic	21623372
YEH1_YEAST	YEH1	genetic	21623372
COX5A_YEAST	COX5A	genetic	21623372
ARO1_YEAST	ARO1	genetic	21623372
GAS1_YEAST	GAS1	genetic	23891562
BGL2_YEAST	BGL2	physical	23208381

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.